Publications by authors named "Lia P A Porto"
Background: Oral squamous cell carcinoma (OSCC) accounts for 90% of oral malignancies, which may be preceded by oral potentially malignant disorders (OPMDs). Cancer progression involves the downregulation of epithelial markers (E-cadherin) and the upregulation of mesenchymal markers (N-cadherin), which together characterise the epithelial-mesenchymal transition (EMT). Furthermore, caveolin can act on cell adhesion and migration events that regulate the expression of the E-cadherin/α-β-catenin complex, thus favouring aggressive biological behaviour.
View Article and Find Full Text PDFImmunohistochemical Characterization of Cancer-associated Fibroblasts in Oral Squamous Cell Carcinoma.
Appl Immunohistochem Mol Morphol
October 2018
Myofibroblasts are differentiated contractile cells that can secrete extracellular matrix components, cytokines, proteases, and proangiogenic factors. In neoplastic processes such as oral squamous cell carcinoma (OSCC), myofibroblasts are recognized as cancer-associated fibroblasts (CAFs) and actively participate in tumor progression. As the presence of myofibroblasts in the stroma may be an important parameter of invasion and proliferation, the aim of this study was to evaluate the presence of CAFs in OSCC by immunophenotyping and their association with histologic classification and clinicopathologic parameters.
View Article and Find Full Text PDFBackground: The epithelial-mesenchymal transition (EMT) is the process where cells lose their epithelial features and acquire properties of typical mesenchymal cells. The dissociation of tumor cells due to changes in cell-cell adhesion is one of the key principles of tumor invasion and EMT. Thus, the knowledge of the molecular features of EMT in keratocyst odontogenic tumor (KOT) can provide useful markers to aid in the diagnosis and prognosis and perhaps contribute to an alternative therapeutic approach as it shows an aggressive clinical behavior and high recurrence rates.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted on 223 adult Kiriri Indians in Northeast Brazil to assess the prevalence of oral mucosal lesions and their associated risk factors.
- Results showed that 22.4% of participants had mucosal lesions, with the most common types being fistulae (6.2%) and traumatic ulcers (4.48%).
- The study found that older age (≥ 35 years) and lower education levels (less than 9 years) were significantly linked to the presence of these lesions, highlighting the need for targeted public health programs to improve oral health in this community.