Publications by authors named "Lia Laura Lewis-Ximenez de Souza Rodrigues"
Article Synopsis
- - The study analyzed the effectiveness of the DCV/SOF treatment regimen for hepatitis C virus (HCV) in Brazilian patients, revealing a high sustained virologic response (SVR) rate of 95.4% among 132 patients, including those coinfected with HIV.
- - It found that drug resistance-associated substitutions (RASs) in the NS5A gene were more prevalent in HCV/HIV co-infected patients (28%) compared to monoinfected patients (16.8%), while differences in the NS5B gene were not significant between the groups.
- - The genetic analysis showed that a significant number of baseline mutations were present, particularly in genotype 1b strains, but these mutations generally did
Prevalence of baseline NS3 resistance-associated substitutions (RASs) on treatment with protease inhibitors in patients infected with HCV genotype 1.
Clin Res Hepatol Gastroenterol
November 2019
Background And Aims: Treatment for hepatitis C has evolved significantly with the licensing of direct-acting antiviral drugs (DAAs). However, one of the limiting factors of the effectiveness of antiviral therapy with protease inhibitors (PIs) is the emergence of resistance caused by point mutations. The aim of this study was to determine the prevalence of resistance-associated substitutions (RASs) in HCV NS3 gene in patients infected with genotype 1 before therapy with simeprevir.
View Article and Find Full Text PDFSince hepatitis A virus (HAV) production is time-consuming and expensive, the use of recombinant proteins may represent an alternative source of antigens for diagnostic purposes. The present study aimed to express, purify and evaluate the potential of recombinant VP1 protein (rVP1) as a marker for the diagnosis of acute HAV infection. The rVP1 was expressed and purified successfully from Escherichia coli.
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