Biosynthetic gene cluster profiling from North Java Sea Virgibacillus salarius reveals hidden potential metabolites.

Virgibacillus salarius 19.PP.SC1.

Sun protection and antibacterial activities of carotenoids from the soft coral sp. symbiotic bacteria from Panjang Island, North Java Sea.

Carotenoids have shown beneficial applications in cosmetology, pharmacology, and medicine. However, environmental stress in the marine environment can trigger the production of unique secondary metabolites, such as carotenoids. These compounds can also be sustainably produced by symbiotic bacteria.

L. carotenoids: antiproliferative activity on human lung cancer, breast cancer, and cervical cancer cells .

Emerging evidence on the potential pro-oxidant effect of carotenoids provokes apoptosis of cancer cells. L. is native to Central and South America, interestingly, is also cultivated worldwide.

Bixin and fucoxanthin sensitize human lung cancer and cervical cancer cell to cisplatin in vitro.

Objective: Cisplatin is a conventional anticancer drug that generates reactive oxygen species and causes apoptosis. However, many cancer cells develop alterations in the ATP binding cassette transporter responsible for the uptake and efflux process, which leads to resistance. Many natural products have shown potential to compete with ATP binding cassette transporter and may sensitize resistant cells to cisplatin.