Publications by authors named "Lia A Bernardi"
Objective: To evaluate the uterine microbiome among women with endometrial polyps and submucosal fibroids and to compare results between endometrial sampling techniques.
Design: Patients with polyps or fibroids were prospectively recruited prior to hysteroscopy, while patients undergoing retrieval for planned oocyte cryopreservation were recruited prospectively as controls. Three specimen types obtained for each patient were the distal 5 mm of an embryo catheter passed to the uterine fundus (C), endometrial tissue from an endometrial biopsy (T), and formalin fixed paraffin embedded endometrial tissue from the same endometrial biopsy (FFPE).
Background: While natural cycle frozen embryo transfer (NC-FET) is becoming increasingly common, significant practice variation exists in the use of ovulation induction medications, administration of ovulation trigger, and timing of embryo transfer without consensus as to the optimal protocol.
Aims: The objective of this study is to evaluate the association of key aspects of the NC-FET protocol with implantation, pregnancy and live birth.
Settings And Design: This was a retrospective cohort study of blastocyst stage NC-FET cycles from October 2019 to July 2021 at a single academic fertility centre.
Objective: To examine the association between serum 25-hydroxyvitamin D [25(OH)D] levels and ovarian reserve as measured using antimüllerian hormone (AMH) levels.
Design: Cross-sectional study.
Setting: Detroit, Michigan area.
Research Question: Are gravidity, parity and breastfeeding history associated with anti-Müllerian hormone concentration among African-American women of reproductive age?
Design: This study included baseline data from the Study of the Environment, Lifestyle and Fibroids, a 5-year longitudinal study of African-American women. Within this community cohort, data from 1392 women aged 25-35 years were analysed. The primary outcome was serum anti-Müllerian hormone concentration measured using the Ansh Labs picoAMH assay, an enzyme-linked immunosorbent assay.
Article Synopsis
- The study looked at how college students feel about having kids in the future, their worries about getting pregnant later, and what they know about fertility as they age.
- About 62.5% of the surveyed students want children, but many (68.3%) plan to wait, especially females and premed students because of school and job goals.
- Most students are anxious about how their careers may affect their chances of having kids, and many want to learn more about fertility since their knowledge about it is not very strong.
Background: As delayed family building is common among physicians, the goal of this study was to evaluate childbearing plans, anxiety related to future fertility, and interest in fertility education among medical students.
Methods: Using convenience and snowball sampling methods, an electronic REDCap survey was distributed via social media and group messaging applications to medical students enrolled in medical schools across the United States. Answers were collected, and analysis of the descriptive statistics was performed.
Purpose: Specific serum beta human chorionic gonadotropin (β-hCG) parameters that can predict live birth after an embryo transfer have yet to be defined.
Methods: We performed a retrospective cohort study of 1,028 patients with a detectable β-hCG who underwent a single embryo transfer between 2002 and 2019 at a large academic center. Two β-hCG parameters were examined in relation to live birth: 1) "doubling" defined as β-hCG doubling over 48 h and 2) "reaching 100" defined as a β-hCG ≥ 100 mIU/mL by 15 days after oocyte retrieval (AOR).
Objective: To evaluate the extent to which uterine fibroids are associated with antimüllerian hormone (AMH) concentrations.
Design: Cross-sectional study.
Setting: Baseline data from the Study of the Environment, Lifestyle, and Fibroids, which is a 5-year longitudinal study of African American women.
Objective: To describe the experiences of three women with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) who desired to pursue planned oocyte cryopreservation.
Design: Case series.
Setting: An academic institution and a private clinic.
Objective: To assess knowledge of female and male fertility among students enrolled in a Master of Business Administration (MBA) program.
Design: Web-based cross-sectional survey.
Setting: Academic setting.
Objective: To determine whether the frequency of euploid miscarriage is increased in obese women with early pregnancy loss.
Design: Retrospective cohort study.
Setting: Academic medical center.
Objective: To assess whether the duration, recency, or type of hormonal contraceptive used is associated with antimüllerian hormone (AMH) levels, given that the existing literature regarding the association between hormonal contraceptive use and AMH levels is inconsistent.
Design: Cross-sectional study.
Setting: Baseline data from the Study of the Environment, Lifestyle and Fibroids Study, a 5-year longitudinal study of African American women.
Objective: To use time-lapse imaging to compare embryo morphokinetic parameters between embryos resulting in euploid pregnancy loss and euploid embryos resulting in live birth.
Design: Retrospective cohort study.
Setting: Single academic fertility center.
Treatment of endometriosis-related chronic pelvic pain with Ulipristal Acetate and associated endometrial changes.
HSOA J Reprod Med Gynaecol Obstet
December 2017
Background: Aberrant progesterone signaling has been demonstrated in mechanistic studies to be a shared common pathway in fibroids and endometriosis. Progesterone receptor modulation with the selective progesterone receptor modulator (SPRM) ulipristal may decrease pain associated with endometriosis.
Case: A 25-year-old nulligravidae with endometriosis-related pelvic pain refractory to medical and surgical intervention was administered 15mg ulipristal every other day for 3 months.
Endometriotic stromal cells synthesize estradiol via the steroidogenic pathway. Nuclear receptor subfamily 5, group A, member 1 (NR5A1) is critical, but alone not sufficient, in activating this cascade that involves at least 5 genes. To evaluate whether another transcription factor is required for the activation of this pathway, we examined whether GATA Binding Protein 6 (GATA6) can transform a normal endometrial stromal cell (NoEM) into an endometriotic-like cell by conferring an estrogen-producing phenotype.
View Article and Find Full Text PDFObjective: To determine whether there is an association between obesity and anti-Müllerian hormone (AMH) among reproductive-aged African American women (AAW).
Methods: From the women participating in an ongoing National Institute of Environmental Health Sciences study, 1,654 AAW aged 23 to 35 were included in this study. Anthropometric measurements, personal health information, and serum AMH and adipokine levels were analyzed.
Background: Both iron deficiency and iron deficiency anemia are common in the United States with a prevalence amongst women of 12 % and 4 % respectively. These numbers are even higher in African-American women (AAW) and are often a result of heavy menstrual bleeding (HMB). The primary objective of this study was to determine if perceived assessment of menstrual bleeding was associated with objective and subjective measures of anemia in AAW.
View Article and Find Full Text PDFBackground: Although alcohol consumption and cigarette smoking are common behaviors in reproductive-age women, little is known about the impact of consumption patterns on ovarian reserve. Even less is known about the effects of smoking and alcohol use in reproductive-age African-American women.
Objective: The objective of the study was to examine the impact of the patterns of alcohol intake and cigarette smoking on anti-Müllerian hormone levels as a marker of ovarian reserve in African-American women.
Objective: To characterize normative antimüllerian hormone (AMH) levels and ascertain which factors are associated with AMH in a large cohort of reproductive-age women.
Design: Cross-sectional study.
Setting: Not applicable.
Ureteral Trauma During Transvaginal Ultrasound-Guided Oocyte Retrieval: A Case Report.
Female Pelvic Med Reconstr Surg
May 2016
Background: Transvaginal ultrasound-guided oocyte retrieval is a safe and well-tolerated procedure. Complications are uncommon and usually limited to vaginal bleeding and pelvic infection. Ureteral injury following oocyte retrieval is exceedingly rare, with only 8 previously reported cases.
View Article and Find Full Text PDFObjective: To determine whether the frequency of euploid miscarriage is increased in obese women with recurrent early pregnancy loss (REPL).
Design: Observational cohort study using prospectively collected data.
Setting: Academic RPL program.