A Ray-Tracing-Based Single-Site Localization Method for Non-Line-of-Sight Environments.

Localization accuracy in non-line-of-sight (NLOS) scenarios is often hindered by the complex nature of multipath propagation. Traditional approaches typically focus on NLOS node identification and error mitigation techniques. However, the intricacies of NLOS localization are intrinsically tied to propagation challenges.

Metrology with a twist: probing and sensing with vortex light.

Optical metrology is a well-established subject, dating back to early interferometry techniques utilizing light's linear momentum through fringes. In recent years, significant interest has arisen in using vortex light with orbital angular momentum (OAM), where the phase twists around a singular vortex in space or time. This has expanded metrology's boundaries to encompass highly sensitive chiral interactions between light and matter, three-dimensional motion detection via linear and rotational Doppler effects, and modal approaches surpassing the resolution limit for improved profiling and quantification.

Improved glycaemic control in people with type 2 diabetes initiating or switching to IDegAsp in a real-world setting in China.

Aims: To investigate glycaemic control in Chinese adults with type 2 diabetes (T2D) initiating, or switching to insulin degludec/insulin aspart (IDegAsp), a co-formulation of basal, and bolus insulin, in a real-world setting.

Materials And Methods: A 20-week, prospective, single-arm, open-label, non-interventional study was conducted in Chinese adults with T2D initiating, or switching to IDegAsp after anti-hyperglycaemic treatment with oral antidiabetic drugs (OADs), other insulins, or glucagon-like peptide-1 receptor agonists. The primary endpoint was a change in HbA from baseline to end of the study; the secondary endpoints included a change in fasting plasma glucose and Diabetes Treatment Satisfaction Questionnaire (DTSQ) score.

Effectiveness and Safety of the TRIO Optimal Health Management Program in Patients With Type 2 Diabetes Mellitus Initiating Basal Insulin Therapy: Prospective Observational Real-World Study.

Background: Diabetes, a chronic disease necessitating long-term treatment and self-management, presents significant challenges for patients who spend most of their treatment time outside of hospitals. The potential of digital therapeutics for diabetes has garnered recognition from different organizations. Although some prior studies have demonstrated successful reductions in patients' blood glucose levels and body weight through digital diabetes programs, many studies were limited by including patients with prediabetes, including patients treated with mostly premixed insulin, or evaluating user engagement outcomes rather than clinical outcomes.

Real-world safety of dapagliflozin plus metformin in patients of type 2 diabetes mellitus in China: Post-hoc analysis of the DONATE study.

Aim: DONATE (NCT03156985) is a large-scale real-world study investigating the safety of dapagliflozin in Chinese type 2 diabetes mellitus (T2DM) patients. This post-hoc analysis aims to further evaluate the real-world safety of dapagliflozin plus metformin.

Methods: Safety outcomes were assessed in patients receiving concomitant dapagliflozin and metformin, with or without other antidiabetics.

Brain structural damage networks at different stages of schizophrenia.

Background: Neuroimaging studies have documented brain structural changes in schizophrenia at different stages of the illness, including clinical high-risk (cHR), genetic high-risk (gHR), first-episode schizophrenia (FES), and chronic schizophrenia (ChS). There is growing awareness that neuropathological processes associated with a disease fail to map to a specific brain region but do map to a specific brain network. We sought to investigate brain structural damage networks across different stages of schizophrenia.

A biweekly DPP-4 inhibitor cofrogliptin monotherapy in Chinese patients with impaired glucose tolerance: A phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-group trial.

Aims: To assess the efficacy and safety of cofrogliptin for impaired glucose tolerance (IGT).

Methods: In this multicenter, double-blind, placebo-controlled phase 2 trial, IGT patients were randomized 1:1:1 to receive cofrogliptin 10 mg, cofrogliptin 25 mg or placebo once biweekly. The primary endpoint was the change from baseline in glucose total AUC during meal tolerance test (MTT) at week 12.

Introduction of a modified anomalous vortex beam with self-focusing properties.

This study introduces and experimentally demonstrates the concept of a modified anomalous vortex beam (MAVB), which carries orbital angular momentum (OAM) and exhibits unique self-focusing properties. By utilizing holographic techniques and customizing phase masks, we precisely control the beam's phase and intensity distribution, enhancing self-focusing behavior while preserving traditional anomalous vortex beam features. We derive an analytical formula to describe MAVB propagation within a paraxial ABCD optical system.

Research on wireless channel model based on improved ray tracing algorithm that considers multiple diffuse scattering and employs pyramid-shaped ray tubes as the carrier.

This paper extensively utilizes fine three dimensional environmental data obtained from laser point clouds. Based on theories such as geometrical optics and effective roughness theory, a deterministic wireless channel model is established, which integrates higher-order diffuse scattering. This model is referred to as the ray tracing fusion with higher-order diffuse scattering model.

Focus tunable vector autofocusing Airy vortex beams resist atmospheric turbulence.

The rapid increase in orbital angular momentum (OAM) mode size with increasing modal order, given the limited-size of the receiver, is a major impediment to high-capacity OAM mode multiplexing in practice. Based on the Pancharatnam-Berry (PB) phase theory, we correlate the change of the polarization state with the curvature of the wavefront isophase line in the source plane and manipulate the focusing ability of vector autofocusing Airy vortex beam (AAVB) by combining the isophase line curvature and the intensity gradient of the beam, which are two independent degrees of freedom. The present method enables flexible on-demand focusing of vector AAVBs in free space and is more effective in focusing higher order OAM modes, which can reduce the full-width at half maximum (FWHM) of the AAVB with topological charge l= 25 to 1/5 of that of the conventional scalar type.

Association between physical activity and mortality in patients with osteoporosis: a cohort study of NHANES.

Unlabelled: We utilized data from the NHANES to investigate the impact of physical activity on mortality in osteoporotic patients. Our study suggests that osteoporotic patients may require higher volumes of physical activity to reduce mortality risk compared to the general population. In osteoporotic patients, the dose-response relationships between physical activity volumes and both all-cause and cardiovascular mortality were linear.

Efficacy and Safety of Pioglitazone/Metformin Fixed-Dose Combination Versus Uptitrated Metformin in Patients with Type 2 Diabetes without Adequate Glycemic Control: A Randomized Clinical Trial.

Introduction: We aim to evaluate the efficacy and safety of pioglitazone/metformin fixed-dose combination (FDC) versus uptitrated metformin in patients with type 2 diabetes mellitus (T2DM) without adequate glycemic control.

Methods: A total of 304 patients were recruited from 15 hospitals in China and randomly assigned (1:1) to the test group (pioglitazone/metformin FDC, 15/500 mg) or the control group (uptitrated metformin, 2000-2500 mg/day). The primary endpoint was the proportion of patients with glycated hemoglobin A1c (HbA1c) ≤ 6.

Molecular mechanisms and behavioral relevance underlying neural correlates of childhood neglect.

Background: Childhood neglect is associated with brain changes, yet the molecular mechanisms and behavioral relevance underlying such associations remain elusive.

Methods: We calculated fractional amplitude of low-frequency fluctuations (fALFF) using resting-state functional MRI and tested their correlation with childhood neglect across a large sample of 510 healthy young adults. Then, we investigated the spatial relationships of the identified neural correlates of childhood neglect with gene expression, neurotransmitter, and behavioral domain atlases.

Excessive Daytime Napping Increases the Risk of Non-Alcoholic Fatty Liver Disease: A Meta-Analysis and a Mendelian Randomization Study.

Background: Prior research based on observations has furnished evidence that supports a connection between daytime napping and the prevalence of non-alcoholic fatty liver disease (NAFLD). Nevertheless, the question of whether this correlation is indicative of a causal link has not been definitively answered.

Methods: We used meta-analysis and Mendelian randomization (MR) to synthesize genetic and observational data.

Destruction mechanism of anterior cervical discectomy and fusion in frontal impact.

The aim of this study was to quantitatively study the effect of anterior cervical discectomy and fusion (ACDF) on the risk of spinal injury under frontal impact. A head-neck finite element model incorporating active neck muscles and soft tissues was developed and validated. Based on the intact head-neck model, three ACDF models (single-level, two-level and three-level) were used to analyze the frontal impact responses of the head-neck.

[Retracted] Sirt1 inhibits HG‑induced endothelial injury: Role of Mff‑based mitochondrial fission and F‑actin homeostasis‑mediated cellular migration.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the immunochemistry data shown in Figs. 4K and 7G were strikingly similar to data appearing in different form in other research articles written by different authors at different research institutes that had either already been published, or were submitted for publication at around the same time. Owing to the fact that contentious data in the above article had already been published elsewhere prior to its submission to , the Editor has decided that this paper should be retracted from the Journal.