transmission electron microscopy insights into nanoscale deformation mechanisms of body-centered cubic metals.

Nanostructured body-centered cubic (BCC) metals exhibit remarkable mechanical properties under various stress fields, making them promising candidates for novel micro/nanoelectromechanical systems (M/NEMS). A deep understanding of their mechanical behaviors, particularly at the atomic scale, is essential for optimizing their properties and expanding their applications at the nanoscale. Newly developed nanomechanical testing techniques within transmission electron microscopy (TEM) provide powerful tools for uncovering the atomic-scale microstructural evolution of nanostructured BCC materials under external forces.

Processing and properties of graphene-reinforced polylactic acid nanocomposites for bioelectronic and tissue regenerative functions.

An in-situ polymer-solution-processing approach enables the efficient production of uniform graphene-reinforced polylactic acid (G-PLA) nanocomposites with notable physical and biomedical properties. The approach effectively enhances the interfacial bonding between graphene and PLA by creating graphene dangling bonds and defects during exfoliation. As a result, an 182 % increase in Young's modulus and an 85 % increase in tensile strength can be achieved in G-PLA.

Atomic Fabrication of 2D Materials Using Electron Beams Inside an Electron Microscope.

Two-dimensional (2D) materials have garnered increasing attention due to their unusual properties and significant potential applications in electronic devices. However, the performance of these devices is closely related to the atomic structure of the material, which can be influenced through manipulation and fabrication at the atomic scale. Transmission electron microscopes (TEMs) and scanning TEMs (STEMs) provide an attractive platform for investigating atomic fabrication due to their ability to trigger and monitor structural evolution at the atomic scale using electron beams.

Electric Field-Dependent Evolution Dynamics of Conductive Filaments in 2D Material-Based Planar Memristors.

2D materials have emerged as potential building blocks for electrochemical metallization (ECM) memristors with excellent performance. The evolution dynamics of conductive filaments (CFs) directly determine the resistance switching performance of the 2D material-based ECM memristors. However, achieving controllable CFs under the operation conditions remains challenging.

Evaluation of the Role of Tanshinone I in an In Vitro System of Charcot-Marie-Tooth Disease Type 2N.

Charcot-Marie-Tooth disease type 2N (CMT2N) is an inherited nerve disorder caused by mutations in the alanyl-tRNA synthetase (AlaRS) gene, resulting in muscle weakness and sensory issues. Currently, there is no cure for CMT2N. Here, we found that all five AlaRS mutations in the aminoacylation domain can interact with neuropilin-1 (Nrp1), which is consistent with our previous findings.

Superhydrophobic Porous Cylindrical Barrel Founded on Stainless-Steel Mesh for Interfacial Water Evaporation.

Superhydrophobic materials have been widely applied in oil-water separation, self-cleaning, antifouling, and drag reduction; however, their role in liquid evaporation and drying remains unexplored. Inspired by the microstructure of the nonwetting legs of water striders, we designed a low-adhesion superhydrophobic cylindrical barrel (CB) derived from stainless-steel mesh (SSM) to enhance liquid thermal evaporation and drying. The CB was created by hydrothermally depositing zinc oxide (ZnO) with multilevel morphologies onto metal wires, followed by modification with low-surface-energy stearic acid (SA).

Defect-Mediated Formation of Oriented Phase Domains in a Lithium-Ion Insertion Electrode.

The performance and robustness of electrodes are closely related to transformation-induced nanoscale structural heterogeneity during (de)lithiation. As a result, it is critical to understand at atomic scale the origin of such structural heterogeneity and ultimately control the transformation microstructure, which remains a formidable task. Here, by performing in situ studies on a model intercalation electrode material, anatase TiO, we reveal that defects─both preexisting and as-formed during lithiation─can mediate the local anisotropic volume expansion direction, resulting in the formation of multiple differently oriented phase domains and eventually a network structure within the lithiated matrix.

Stabilizing ultra-close Pt clusters on all-in-one CeO/AlO fibril-in-tubes against sintering.

Metal sintering poses significant challenges for developing reliable catalytic systems toward high-temperature reactions, particularly those based on metal clusters with sizes below 3 nm. In this work, electrospun dual-oxide fibril-in-tubes consisting of CeO and AlO are rationally designed in an all-in-one manner, to stabilize 2.3 nm Pt clusters with a Tammann temperature (sintering onset temperature) lower than 250 °C.

Resveratrol liposomes reverse sorafenib resistance in renal cell carcinoma models by modulating PI3K-AKT-mTOR and VHL-HIF signaling pathways.

RCC is a malignant tumor arising from the urothelium of renal parenchyma that remains challenging to be treated. In this study, we assessed the anti-tumor effects of Resveratrol liposomes (RES-lips) combined with sorafenib on renal cell carcinoma (RCC) and explored the potential mechanisms underlying the improvement of sorafenib resistance models. Tumor growth and survival following treatment with sorafenib alone or in combination with RES-lips was evaluated in a RCC xenograft mouse model.

Based on 3D-PDU and clinical characteristics nomogram for prediction of lymph node metastasis and lymph-vascular space invasion of early cervical cancer preoperatively.

Purpose: To develop and validate a nomogram based on 3D-PDU parameters and clinical characteristics to predict LNM and LVSI in early-stage cervical cancer preoperatively.

Materials And Methods: A total of first diagnosis 138 patients with cervical cancer who had undergone 3D-PDU examination before radical hysterectomy plus lymph dissection between 2014 and 2019 were enrolled for this study. Multivariate logistic regression analyses were performed to analyze the 3D-PDU parameters and selected clinicopathologic features and develop a nomogram to predict the probability of LNM and LVSI in the early stage.

Deep learning-assisted two-dimensional transperineal ultrasound for analyzing bladder neck motion in women with stress urinary incontinence.

Background: No universally recognized transperineal ultrasound parameters are available for evaluating stress urinary incontinence. The information captured by commonly used perineal ultrasound parameters is limited and insufficient for a comprehensive assessment of stress urinary incontinence. Although bladder neck motion plays a major role in stress urinary incontinence, objective and visual methods to evaluate its impact on stress urinary incontinence remain lacking.

The Contact Properties of Monolayer and Multilayer MoS-Metal van der Waals Interfaces.

The contact resistance formed between MoS and metal electrodes plays a key role in MoS-based electronic devices. The Schottky barrier height (SBH) is a crucial parameter for determining the contact resistance. However, the SBH is difficult to modulate because of the strong Fermi-level pinning (FLP) at MoS-metal interfaces.

Ocr-mediated suppression of BrxX unveils a phage counter-defense mechanism.

The burgeoning crisis of antibiotic resistance has directed attention to bacteriophages as natural antibacterial agents capable of circumventing bacterial defenses. Central to this are the bacterial defense mechanisms, such as the BREX system, which utilizes the methyltransferase BrxX to protect against phage infection. This study presents the first in vitro characterization of BrxX from Escherichia coli, revealing its substrate-specific recognition and catalytic activity.

In Situ Lattice-Resolution Revelation of the Origins of Unexplored Anisotropic Sodiation Kinetics and Phase Transition in the Niobium Sulfide Anode.

Layered transition metal dichalcogenides (TMDs) have exhibited huge potential as anode materials for sodium-ion batteries. Most of them usually store sodium via an intercalation-conversion mechanism, but niobium sulfide (NbS) may be an exception. Herein, through in situ transmission electron microscopy, we carefully investigated the insertion behaviors of Na ions in NbS and directly visualized anisotropic sodiation kinetics.

Size-Effect-Based Dimension Compensations in Wet Etching for Micromachined Quartz Crystal Microstructures.

Microfabrication technology with quartz crystals is gaining importance as the miniaturization of quartz MEMS devices is essential to ensure the development of portable and wearable electronics. However, until now, there have been no reports of dimension compensation for quartz device fabrication. Therefore, this paper studied the wet etching process of Z-cut quartz crystal substrates for making deep trench patterns using Au/Cr metal hard masks and proposed the first quartz fabrication dimension compensation strategy.

Structure-Based Virtual Screening, ADMET Properties Prediction and Molecular Dynamics Studies Reveal Potential Inhibitors of HPrK/P.

pneumonia (MPP) is a frequent cause of community-acquired pneumonia (CAP) in children. The incidence of childhood pneumonia caused by infection has been rapidly increasing worldwide. is naturally resistant to beta-lactam antibiotics due to its lack of a cell wall.

Anti-PD-L1 antibody retains antitumour effects while mitigating immunotherapy-related colitis in bladder cancer-bearing mice after CT-mediated intratumoral delivery.

Drug local delivery system that directly supply anti-cancer drugs to the tumor microenvironment (TME) results in excellent tumor control and minimizes side effects associated with the anti-cancer drugs. Immune checkpoint inhibitors (ICIs) have been the mainstay of cancer immunotherapy. However, the systemic administration of ICIs is accompanied by considerable immunotherapy-related toxicity.

Enhancing bone regeneration and immunomodulation via gelatin methacryloyl hydrogel-encapsulated exosomes from osteogenic pre-differentiated mesenchymal stem cells.

Mesenchymal stem cell-derived exosomes (MSC-Exos) have emerged as promising candidates for cell-free therapy in tissue regeneration. However, the native osteogenic and angiogenic capacities of MSC-Exos are often insufficient to repair critical-sized bone defects, and the underlying immune mechanisms remain elusive. Furthermore, achieving sustained delivery and stable activity of MSC-Exos at the defect site is essential for optimal therapeutic outcomes.

Perioperative echocardiography in minimally invasive surgery for hypertrophic obstructive cardiomyopathy.

Background: Hypertrophic obstructive cardiomyopathy (HOCM) is clinically symptomatic and prone to malignant arrhythmias and sudden cardiac death (SCD). Currently, an effective treatment is surgical resection of the hypertrophic ventricular septum to relieve the left ventricular outflow tract (LVOT) obstruction and mitral insufficiency. Our center performs an innovative, minimally invasive right infra-axillary thoracotomy for transaortic septal myectomy.

The ultrasound-guided versus standard technique for peripheral intravenous catheter placement by nurses: A systematic review and meta-analysis.

Aim: To comprehensively evaluate the efficacy of Ultrasound-guided technique for peripheral intravenous catheter placement by nurses in their daily practice.

Background: Peripheral intravenous catheter insertion is a common clinical procedure in healthcare settings. Ultrasound-guided peripheral intravenous placement has emerged in recent decades and was recognized as particularly useful in some specific patient groups.

Network-based approach for drug repurposing against mpox.

The current outbreak of mpox presents a significant threat to the global community. However, the lack of mpox-specific drugs necessitates the identification of additional candidates for clinical trials. In this study, a network medicine framework was used to investigate poxviruses-human interactions to identify potential drugs effective against the mpox virus (MPXV).