Diabetes Res Clin Pract
March 2025
Aims: Haptoglobin (HP) phenotype has been reported to modulate fenofibrate benefit on coronary artery disease in type 2 diabetes. It is unknown whether HP phenotype and levels modulate fenofibrate benefit on sight-threatening diabetic retinopathy (STDR).
Methods: In plasma from 8,047 Australasian adults with type 2 diabetes in the FIELD trial, HP phenotype was determined, and HP levels were measured at baseline and after six-week fenofibrate run-in.
Tunable multicolor luminescence materials can flexibly meet the needs of smart lighting, enabling efficient light energy use and minimizing waste. Lead-free hybrid double perovskites AMM(NO) hold great potential in luminescence, benefiting from their tunable composition, high light absorption, low synthesis cost, and environmental friendliness. However, achieving tunable multicolor emission within a single matrix of these materials has yet to be realized.
View Article and Find Full Text PDFThe tumor-stroma ratio (TSR) has been regarded as an important factor associated with tumor metastasis, based on the 'seed and soil' theory, which may have guiding significance for the selection of chemotherapy regimens. Therefore, a high TSR may be a new risk factor for tumor recurrence in patients with stage II colorectal cancer (CRC). The present study aimed to evaluate the prognostic value of TSR in CRC, especially for the computer-calculated TSR.
View Article and Find Full Text PDFObjectives: This study aims to develop sarcopenia risk prediction models for Chinese older adults at different time intervals and to identify and compare modifiable factors contributing to sarcopenia development.
Methods: This study used data from 3,549 participants aged 60 and older in the China Health and Retirement Longitudinal Study (CHARLS). Sarcopenia status was evaluated by the AWGS2019 algorithm.
Nat Cancer
February 2025
Cabozantinib is an oral multikinase inhibitor approved for treatment in metastatic renal cell carcinoma (RCC). We conducted a phase 2, nonrandomized, single-arm clinical trial (NCT04022343) of cabozantinib treatment for 12 weeks in 17 patients with locally advanced, biopsy-proven, nonmetastatic clear cell RCC before surgical resection. The primary end point was the objective response rate (complete and partial responses) at week 12 and secondary end points included safety, tolerability, clinical and surgical outcomes, and quality of life.
View Article and Find Full Text PDFPhosphorus is one of the key contributors to the eutrophication of aquatic ecosystems. With the rapid growth of the aquaculture industry, aquaculture effluent has gradually become a significant source of phosphorus pollution. However, this important phosphorous source has often been overlooked in previous studies.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
February 2025
Present design and application of perovskite oxide catalysts assume lattice oxygen redox (LOR) mechanisms that depend on lattice oxygen activity without consideration of the entire redox cycle. Herein, using in situ characterizations and theoretical calculations, we uncover a hole-mediated LOR cycle on p-type Sr-deficient SrFeO (SFO-Srv) perovskites in CO oxidation reaction. Sr vacancies activate surface lattice oxygen of SFO-Srv and promote formation of highly covalent Fe-O sites.
View Article and Find Full Text PDFThis study aimed to determine the effects of polyethylene glycol loxenatide (PEG-Loxe), a glucagon-like peptide-1 receptor agonist, on a three-point major adverse cardiovascular event (3P-MACE) in patients with type 2 diabetes mellitus (T2DM). The study was conducted in six tertiary hospitals in three cities in China. Large language models were used to retrospectively screen and include 12,341 patients with T2DM who had either cardiovascular disease or cardiovascular risk factors.
View Article and Find Full Text PDFBackground: The standards for diagnosing, monitoring, and treating endocrine diseases in pediatric patients often rely on laboratory assessments of children's growth and differentiation markers, among which sex hormones are pivotal. Nonetheless, due to the rapid development during childhood and adolescence and the substantial physiological differences between children and adults, sex hormone levels undergo significant fluctuations. Unfortunately, few laboratories in China currently provide reliable reference intervals (RIs) for children's sex hormones.
View Article and Find Full Text PDFThe effect of heavy metal availability and interaction in feed on feces heavy metal excretion in mice has rarely been investigated. In this work, feed containing a polluted soil (total Cd = 6.34, total Pb = 387 mg kg) amended with phosphate, bentonite and lime, or feed spiked with soluble Pb and Cd were fed to mice for 10 days.
View Article and Find Full Text PDFEpithelial-to-mesenchymal transition (EMT) is a critical and complex process involved in normal embryonic development, tissue regeneration, and tumor progression. It also contributes to retinal diseases, such as age-related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR). Although absent in melanoma 2 (AIM2) has been linked to inflammatory disorders, autoimmune diseases, and cancers, its role in the EMT of the retinal pigment epithelium (RPE-EMT) and retinal diseases remains unclear.
View Article and Find Full Text PDFOur manuscript reviewed the enormous number of deaths caused by different types of injuries in China and around the world and proposed a new motivation for injury prevention to address sharp demographic changes and promote constant economic growth when China faces ageing, fewer children and industrial upgrading.
View Article and Find Full Text PDFAccurate and selective techniques for visualizing endogenous peroxynitrite (ONOO) in cerebral ischemia-reperfusion injury (CIRI) models are essential for understanding its complex pathological processes. Here, we introduced a longwave fluorescent probe TJO for detecting ONOO rapidly and sensitively, with a low detection limit of 91 nM. Furthermore, TJO exhibits excellent fluorescence imaging capabilities, enabling detailed visualization of ONOO⁻ in CIRI mice model.
View Article and Find Full Text PDFBackground: Gastric cancer (GC) is an important cause of death. Molecular targeted therapy and immunotherapy are progressing rapidly. It is very important to explore the pathogenesis pathways of GC and provide strong support for its treatment.
View Article and Find Full Text PDFWe designed a SiO@C/MnO composite material with ultrafine particle size using a simple sol-gel method and calcination process. SiO and MnO components produce a mutual suppression effect during the charge/discharge process to mitigate volume expansion and maintain the long-term stability of composite.
View Article and Find Full Text PDFVanadium dioxide (VO) has attracted significant attention in aqueous zinc ion batteries (AZIBs) owing to their desirable theoretical specific capacity originated from multiple electrons transfer reaction and special crystal structure. However, sluggish electrochemical kinetics leads to inferior electrochemical storage performance. Herein, rich vanadium vacancies were introduced in tunnel VO to boost Zn diffusion, increasing charge storage capacity and lengthen lifespan.
View Article and Find Full Text PDFYeast shows promise as a delivery system for drugs and vaccines due to its specific targeting and immunogenic properties. The objective of this research is to create novel and effective yeast-based methods for delivering subunit vaccines. Through the modification of yeast expression plasmids and optimization of expression techniques, a new dual-expression system has been developed.
View Article and Find Full Text PDFBackground & Aims: HBV-related acute-on-chronic liver failure (HBV-ACLF) is a severe acute liver injury secondary to HBV-related chronic liver disease (with or without cirrhosis) and is characterized by a high short-term mortality rate. Presently, there is a paucity of experimental models that specifically focus on HBV-ACLF based on chronic hepatitis B. Therefore, this study aimed to establish an experimental mouse model of HBV-ACLF using chronic hepatitis B (CHB) as a basis and investigate the impact of STING activation on the disease.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
March 2025
Acetylcholinesterase (AChE) plays a vital role in various neurological diseases including brain disorders, neurotransmission alterations, and cancer. Developing effective methods to image AChE in biological samples is essential for understanding its mechanisms in biosystems. Here, we introduce a novel fluorescent probe CNA, that enables detection of AChE at 520 nm with rapid response time of 60 s and a detection limit of 0.
View Article and Find Full Text PDFPepper is a significant cash crop, and is an exemplary variety of pepper cultivated for its distinctive flavor and substantial nutritional value. Polyploidization of plants often leads to an increase in their biomass and improved stress tolerance, and thus has important applications in plant breeding and improvement. In this study, germplasm innovation was carried out by polyploidy induction of by colchicine.
View Article and Find Full Text PDFEcotropic viral integration site 1 (EVI1/MECOM) is frequently upregulated in myeloid malignancies. Here, we present an Evi1-transgenic mouse model with inducible expression in hematopoietic stem/progenitor cells (HSPCs). Upon induction of Evi1 expression, mice displayed anemia, thrombocytopenia, lymphopenia, and erythroid and megakaryocyte dysplasia with a significant expansion of committed myeloid progenitor cells, resembling human myelodysplastic syndrome/myeloproliferative neoplasm-like (MDS/MPN-like) disease.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
March 2025
In this study, we introduced a novel fluorescent probe RNP, which demonstrated outstanding sensitivity and specificity for phosgene detection. Upon phosgene exposure, the probe exhibited rapid fluorescence turn-on within a short re-sponse time (6 s). RNP was also effective in both cellular and murine experiments, where fluorescence enhancement was observed in the respiratory tract of mice.
View Article and Find Full Text PDFDiabetes Obes Metab
February 2025
Aims: To assess the efficacy and safety of cofrogliptin for impaired glucose tolerance (IGT).
Methods: In this multicenter, double-blind, placebo-controlled phase 2 trial, IGT patients were randomized 1:1:1 to receive cofrogliptin 10 mg, cofrogliptin 25 mg or placebo once biweekly. The primary endpoint was the change from baseline in glucose total AUC during meal tolerance test (MTT) at week 12.