Transcriptome analysis reveals differential gene expression in intramuscular adipose tissues of Jinhua and Landrace pigs.

Meat is a rich source of protein, fatty acids and carbohydrates for human needs. In addition to necessary nutrients, high fat contents in pork increase the tenderness and juiciness of the meat, featuring diverse application in various dishes. This study investigated the transcriptomic profiles of intramuscular adipose tissues in Jinhua and Landrace pigs by employing advanced RNA sequencing.

Embedding Carbon Nitride into a Covalent Organic Framework with Enhanced Photocatalysis Performance.

We report a new strategy to construct porous carbon nitride (PCN) by embedding a heptazine unit-the primary building block of carbon nitride-into the backbone of a covalent organic framework (COF). The strategy results in a new type of PCN which bears a fibrous morphology, high surface area and wide visible absorption. The photocatalytic performance was evaluated by photodegradation of an organic dye.

Stereoselective Synthesis of Homofarnesenes: Establishment of an Efficient Method for the Stereoselective Preparation of Acyclic Tetrasubstituted Olefins.

A new method for the stereoselective synthesis of tetrasubstituted olefins is described. β-Ketophosphonates are alkylated via conventional methods, and a Grignard reagent is used to diastereoselectively add to the carbonyl group of the resulting intermediates. The elimination of hydroxyl phosphonates yielded the desired tetrasubstituted olefins in a stereoselective manner.

Polyacrylonitrile-Derived Sponge-Like Micro/Macroporous Carbon for Selective CO Separation.

CO capture under a dynamical flow situation requires adsorbents possessing balanced proportion of macropores as diffusion path and micropores as adsorption reservoir. However, the construction of interconnected micro-/macropores structure coupled with abundant nitrogen species into one carbon skeleton remains a challenge. Here, we report a new approach to prepare sponge-like carbon with a well-developed micro-/macroporous structure and enriched nitrogen species through aqueous phase polymerization of acrylonitrile in the presence of graphene oxide.

Single nucleotide variant profiles of viable single circulating tumour cells reveal CTC behaviours in breast cancer.

Circulating tumour cell (CTC) behaviours are distinct from those of bulk tissues. Thus, treatments to eliminate CTCs differ from the regimens followed to reduce the primary tumour and its metastases. Accordingly, comprehensively deciphering the single nucleotide variant (SNV) profiles in CTCs, which partially determine CTC behaviours, is a priority.

Designing and facilely synthesizing a series of cobalt nitride (CoN) nanocatalysts as non-enzymatic glucose sensors: A comparative study toward the influences of material structures on electrocatalytic activities.

Designing high-efficiency electrocatalysts for glucose concentration detection plays a pivotal role in developing various non-enzymatic glucose detection devices. Herein, we have successfully designed and synthesized various cobalt nitrides (CoN) by using different weak bases (i.e.

The Effects of Berberine on Concanavalin A-Induced Autoimmune Hepatitis (AIH) in Mice and the Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase (AMPK) Pathway.

BACKGROUND Berberine, a herbal extract, has been reported to protect against inflammatory disorders. The adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway can be activated by berberine and inhibited by the synthetic, reversible AMP-competitive inhibitor, Compound C. The aim of this study was to investigate the effects of berberine on concanavalin A (Con A)-induced autoimmune hepatitis (AIH) in mice via the AMPK pathway.

Morphological and molecular divergence of Rhipicephalus turanicus tick from Albania and China.

Rhipicephalus turanicus is an important tick species potentially carrying tick-borne pathogens. Several tick species have obvious subspecies divergence. However few studies aimed to examine the existence of divergence within R.

Contrastive study on porphyrinic iron metal-organic framework supported on various carbon matrices as efficient electrocatalysts.

Porphyrinic iron metal-organic framework (pFeMOF) was combined with different kinds of carbon matrices, including porous graphene (PG), ordered mesoporous carbon (OMC) and macroporous carbon (MPC) via a simple one-step hydrothermal method. The introduction of carbon substrates improves the electrical conductivity and stability of pFeMOF. The presence of carbon also reduces the size of pFeMOF crystallites, leading to more active sites.

Pt nanoparticles supported on nitrogen-doped porous graphene for sensitive detection of Tadalafil.

Graphene (GR) is one of the most promising candidates for utilization in the electroanalytical field because of its superior electrocatalytic activity, excellent electronic conductivity, and high chemical stability. However, the GR sheets usually tend to stack together with π-π interaction. The spontaneous stacking leads to the aggregation of the GR sheets and imposes a negative feedback in the surface area of the GR, which obviously limits its electrochemical application.

[Huoxiang Zhengqi formulas for treatment of gastrointestinal type cold：a systematic review and Meta-analysis].

This systematic review aims to evaluate the efficacy and safety of Huoxiang Zhengqi formulas in treating gastrointestinal type cold. Seven electronic databases,including CNKI, WanFang Data, Vip, SinoMed, PubMed, Cochrane Library, Embase will be searched from the inception of the study until March 2017.All randomized controlled trials that evaluate the treatment of Huoxiang Zhengqi formulas for gastrointestinal type cold will be eligible.

[EGFR and KRAS Gene Mutations in 754 Patients with Resectable Stage I-IIIa Non-small Cell Lung Cancer and Its Clinical Significance].

Background: Epidermal growth factor receptor (EGFR) and KRAS gene are important driver genes of non-small cell lung cancer (NSCLC). The studies are mainly focused on detection of EGFR gene for advanced NSCLC, and the mutation feature of EGFR and KRAS gene in early NSCLC tissue is unknown. This study aims to investigate the mutations of EGFR and KRAS gene in NSCLC, and the relationship between the genotype and clinicopathologic features.

Covalent Triazine Frameworks via a Low-Temperature Polycondensation Approach.

Covalent triazine frameworks (CTFs) are normally synthesized by ionothermal methods. The harsh synthetic conditions and associated limited structural diversity do not benefit for further development and practical large-scale synthesis of CTFs. Herein we report a new strategy to construct CTFs (CTF-HUSTs) via a polycondensation approach, which allows the synthesis of CTFs under mild conditions from a wide array of building blocks.

JinqiJiangtang tablets for pre-diabetes: A randomized, double-blind and placebo-controlled clinical trial.

This study observed the efficacy and safety of JinqiJiangtang tablets (JQJT tablets, a traditional Chinese patent medicine) for pre-diabetes. Four hundred patients with pre-diabetes at five centres were treated for 12months and followed for an additional 12months to investigate the preventative effects of JQJT tablets (Registration ID: ChiCTR-PRC-09000401). The incidence rate of diabetes mellitus was the primary endpoint.

Comparative study of carbon fiber structure on the electrocatalytic performance of ZIF-67.

In this study, novel ZIF-67@carbon fiber composites were fabricated by a simple and facile approach. In order to explore the influence of carbon fiber structure on enhancing the electrocatalytic efficiency of the ZIF-67, different structural carbon fibers (hollow porous carbon fiber (PCF) and solid carbon fiber (SCF)) were used for preparing ZIF-67/carbon fiber catalysts. ZIF-67/carbon fiber composites were characterized via X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy and electrochemical methods.

Proteomic analysis of broccoli sprouts by iTRAQ in response to jasmonic acid.

Jasmonic acid (JA) is well known as a linolenic acid-derived signal molecule related to the plant response to biotic and abiotic stresses. JA can regulate various plant metabolisms, such as glucosinolate metabolism. In this study, the proteome profiles of broccoli sprouts under JA treatment were analyzed using the iTRAQ-based quantitative proteome approach.

Simultaneous and sensitive electrochemical detection of dihydroxybenzene isomers with UiO-66 metal-organic framework/mesoporous carbon.

The zirconium-based MOF (UiO-66)/mesoporous carbon (MC) composite was synthesized using conventional hydrothermal method for the first time. The surface morphology and structure of UiO-66/MC composite were characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). A novel electrochemical sensor based on UiO-66/MC was constructed for simultaneous and sensitive determination of dihydroxybenzene isomers (DBIs) of hydroquinone (HQ), catechol (CT) and resorcinol (RS).

The ACE2-Ang (1-7)-Mas receptor axis attenuates cardiac remodeling and fibrosis in post-myocardial infarction.

Myocardial remodeling serves an important role in the pathophysiology of coronary heart disease. The angiotensin-converting enzyme (ACE)2-angiotensin-(1-7) [Ang (1‑7)]‑Mas receptor (MasR) axis is a key regulator in myocardial remodeling and development of heart failure. To investigate how ACE2‑Ang‑(1‑7)‑MasR axis function on myocardial remodeling and cardiac fibrosis in post‑myocardial infarction (MI), male Sprague‑Dawley rats (weight, 200±20 g) were used to establish the model of myocardial infarction by ligating the left coronary artery.

West Nile virus infectious replicon particles generated using a packaging-restricted cell line is a safe reporter system.

West Nile virus (WNV) is a neurotropic pathogen which causes zoonotic disease in humans. Recently, there have been an increasing number of infected cases and there are no clinically approved vaccines or effective drugs to treat WNV infections in humans. The purpose of this study was to facilitate vaccine and antiviral drug discovery by developing a packaging cell line-restricted WNV infectious replicon particle system.

The mechanism of TGF-β/miR-155/c-Ski regulates endothelial-mesenchymal transition in human coronary artery endothelial cells.

Human coronary artery endothelial cells (HCAECs) have the potential to undergo fibrogenic endothelial-mesenchymal transition (EndMT), which results in matrix-producing fibroblasts and thereby contributes to the pathogenesis of cardiac fibrosis. Recently, the profibrotic cytokine transforming growth factor-β (TGF-β) is shown to be the crucial pathogenic driver which has been verified to induce EndMT. C-Ski is an important regulator of TGF-β signaling.

Genome-wide comparative transcriptome analysis of CMS-D2 and its maintainer and restorer lines in upland cotton.

Background: Cytoplasmic male sterility (CMS) conferred by the cytoplasm from Gossypium harknessii (D2) is an important system for hybrid seed production in Upland cotton (G. hirsutum). The male sterility of CMS-D2 (i.

Reactivity of 1,3-Disubstituted Indoles with Lithium Compounds: Substituents and Solvents Effects on Coordination and Reactivity of Resulting 1,3-Disubstituted-2-Indolyl Lithium Complexes.

Reactivity of 1,3-disubstituted indolyl compounds with lithium reagents was studied to reveal the substituents and solvent effects on coordination modes and reactivities resulting in different indolyl lithium complexes. Treatment of 1-alkyl-3-imino functionalized compounds 1-R-3-(R'N═CH)CHN [R = Bn, R' = Dipp (HL); R = Bn, R' = Bu (HL); R = CHOCH, R' = Dipp (HL); Dipp = PrCH] with MeSiCHLi or BuLi in hydrocarbon solvents (toluene or n-hexane) produced 1,3-disubstituted-2-indolyl lithium complexes [η:(μ-η:η)-1-Bn-3-(DippN═CH)CHNLi] (1), {[η:(μ-η:η:η)-1-Bn-3-(BuN═CH)CHN][η:η:(μ-η:η)-1-Bn-3-(BuN═CH)CHN][η:(μ-η:η)-1-Bn-3-(BuN═CH)CHN]Li} (2), and [η:η:(μ-η:η)-1-CHOCH-3-(DippN═CH)CHNLi] (3), respectively. The bonding modes of the indolyl ligand were kept in 1 by coordination with donor solvent, affording [η:(μ-η:η)-1-Bn-3-(DippN═CH)CHNLi(THF)] (4).

A genome-wide identification and analysis of the DYW-deaminase genes in the pentatricopeptide repeat gene family in cotton (Gossypium spp.).

The RNA editing occurring in plant organellar genomes mainly involves the change of cytidine to uridine. This process involves a deamination reaction, with cytidine deaminase as the catalyst. Pentatricopeptide repeat (PPR) proteins with a C-terminal DYW domain are reportedly associated with cytidine deamination, similar to members of the deaminase superfamily.

Suspicious outbreak of ventilator-associated pneumonia caused by Burkholderia cepacia in a surgical intensive care unit.

Background: We reviewed Burkholderia cepacia infections in a hospital from 2013-2016 to report a suspicious outbreak that occurred in a surgical intensive care unit in 2015, and to outline the infection control measures adopted thereafter.

Methods: Review of the health care-associated infection data regarding B cepacia via the surveillance system, hospital information system, electronic medical records, and laboratory information system together with the outbreak investigation was managed by the health care-associated infection control team.

Results: During June 1-14, 2015, 4 cases of ventilator-associated pneumonia (VAP) were identified; B cepacia was isolated from endotracheal aspirate samples.

Intraspinal bronchogenic cyst: Series of case reports and literature review.

Purpose: Spinal bronchogenic cysts (SBCs) are rare congenital lesions. The clinical and imaging characteristics and treatment of SBCs are not well known. We studied three cases of SBCs retrospectively, which were registered in our department and analyzed eight case reports which were all published in English, focusing on providing a deeper knowledge of SBCs.