Publications by authors named "LiMing Fang"

Article Synopsis
  • High-quality sleep is crucial for both physical health and brain function, but periodic leg movements during sleep (PLMS) can disrupt it and affect many people globally.
  • Traditional methods for monitoring PLMS, like polysomnography, are expensive and not practical for long-term home use.
  • This study introduces a new method using flexible sensors (TENGs) to accurately detect PLMS with enhanced signal processing, offering a comfortable and cost-effective solution for monitoring sleep at home.
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To plant crops (especially dry crops such as water spinach) with concomitant electricity recovery, a hanging-submerged-plant-pot system (HSPP) is developed. The HSPP consists of a soil pot (anodic) partially submerged under the water surface of a cathode tank. The microbial communities changed with conditions were also investigated.

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Sleep plays a role in maintaining our physical well-being. However, sleep-related issues impact millions of people globally. Accurate monitoring of sleep is vital for identifying and addressing these problems.

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  • The study aimed to determine if multimodal analgesia can reduce opioid use after shoulder arthroscopy in patients with subacromial impingement syndrome.
  • A total of 132 patients were analyzed, with one group using traditional opioid methods and another group using multimodal analgesia, including a subacromial pump and oral medications.
  • Results showed that the multimodal group experienced significantly lower pain levels, less opioid usage, and fewer complications, along with better health scores one week post-surgery compared to the control group.
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  • - Transportation damage to fresh produce is a significant issue, and existing sensors for monitoring collisions are costly, power-dependent, and not environmentally friendly.
  • - A new self-powered triboelectric sensor made from natural materials has been developed, demonstrating high efficiency and stability, capable of monitoring collisions effectively during transport.
  • - Tests showed that this sensor's output increased with vibration frequency and packing variations, suggesting it could help create smarter food packaging systems to minimize losses in the supply chain.
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Magnetoelectric stimulation is a promising therapy for various disorders due to its high efficacy and safety. To explore its potential in chronic skin wound treatment, we developed a magnetoelectric dressing, CFO@CTAB/PVDF (CCP), by electrospinning cetyltrimethylammonium bromide-modified CoFeO (CFO) particles with polyvinylidene fluoride. Cetyltrimethylammonium bromide (CTAB) serves as a dispersion surfactant for CFO, with its quaternary ammonium cations imparting antibacterial and hydrophilic properties to the dressing.

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  • The study investigates the rising concerns regarding the toxicity of Chinese Herbal Medicine (CHM) over the past decade, highlighting a lack of comprehensive research in this area.
  • A total of 3,225 publications were analyzed, revealing a significant increase in research output, with the highest number published in 2022, and a specific focus on hepatotoxicity and nephrotoxicity as key areas of interest.
  • Despite growing attention on CHM toxicity, the study emphasizes the need for more in-depth investigations and connections between CHM and toxicological mechanisms, particularly around apoptosis.
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Bacterial infection and insufficient neovascularization are two major obstacles to the healing of chronic wounds. Here, we present an antibacterial and proangiogenic dressing by encapsulating dimethyloxalylglycine (DMOG) in zeolitic imidazolate framework-8 (ZIF-8) and electrospinning it with gelatin-polycaprolactone (Gel-PCL). As Gel-PCL nanofibers degrade, ZIF-8 nanoparticles decompose, sequentially releasing bactericidal zinc ions and angiogenic DMOG molecules.

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Timely diagnosis of medical conditions can significantly mitigate the risks they pose to human life. Consequently, there is an urgent demand for an effective auxiliary model that assists physicians in accurately diagnosing medical conditions based on imaging data. While multi-threshold image segmentation models have garnered considerable attention due to their simplicity and ease of implementation, the selection of threshold combinations greatly influences the segmentation performance.

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Chronic wound healing is often impaired by bacterial infection and weak trans-epithelial potential. Patches with electrical stimulation and bactericidal activity may solve this problem. However, inconvenient power and resistant antibiotics limit their application.

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The "hard to clean" parts of food processing devices (e.g., the corners of pipes) are difficult to disinfect.

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Antimicrobial photodynamic therapy (aPDT) is a highly attractive therapy due to its advantages of being a non-antibiotic procedure for reducing drug-resistant microbes. Curcumin (CCM) has been considered as a natural photosensitizer for PDT with prominent antibacterial, antifungal, and anti-proliferative activity. However, its excellent biological and pharmacological activities are limited because of its low solubility, rapid metabolization and instability.

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The bioequivalence and safety of levetiracetam granules (test formulation) and oral solution (reference formulation) were evaluated in Chinese healthy volunteers under a fasting condition. A total of 24 subjects randomly received the test or reference formulation at the rate of 1:1. The alternative formulation was administered after a 7-day washout period.

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  • Renal cancer (RC) is a common type of urinary system cancer, and this study focuses on circular RNAs (circRNAs) as potential new biomarkers for diagnosing and understanding RC.
  • The researchers reviewed 22 studies, finding that higher levels of circRNAs correlate with poorer survival rates and certain clinicopathological features in RC patients.
  • The analysis showed circRNAs have good diagnostic performance, with a sensitivity of 82% and specificity of 84%, suggesting they are promising indicators for RC diagnosis and prognosis.
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Electrical stimulation as a useful and simple method attracts a lot of attention due to its potential to influence cell behaviors. Reports on the change of cell interior structures and membrane under electrical field would be the possible mechanisms. However, changes in cell behavior caused by protein adsorption under different electric field has not been noticed and discussed yet.

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Combinations of phytochemical(s) and engineered nanoparticles have attracted immense research interest due to their superior antimicrobial effects against contaminations. Herein, a Pickering emulsion is developed with capsulized phytochemicals including borneol and citral (BC-Cap) stabilized by hydrophilic amine-functionalized silica nanoparticles (SiO ─NH NPs). The droplet sizes of Pickering emulsion were 5.

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Food packaging materials, especially biodegradable polymer composites incorporated with natural antimicrobial agents with excellent antibacterial activities, are in high demand and attracted immense attention. Herein, a polycaprolactone/curcumin@zeolitic imidazolate framework-8 (PCL/Cur@ZIF-8) composite film with enhanced antibacterial activity was developed. Curcumin, a natural photosensitizer, was loaded in the highly porous nanocrystals ZIF-8 to improve its poor water solubility and stability.

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  • Conductive polymers (CPs) are typically insoluble, and the development of hydrophilic CPs is crucial for expanding their applications.
  • A novel strategy inspired by mussels was introduced to create hydrophilic CP nanoparticles (CP NPs) that possess redox activity and biocompatibility, which can be applied to multiple CP types like polyaniline and polypyrrole.
  • The resulting CP/LS nanoparticles are effective in producing conductive hydrogels with strong adhesion, good conductivity, and potential uses in tissue regeneration and bioelectronics due to their uniform distribution and dynamic redox properties.
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  • Substrate wettability and stiffness significantly influence cell behaviors, with this study focusing on their interplay.
  • Hydrophilic poly(2-hydroxyethyl methacrylate) modifies PDMS surfaces to explore how different stiffness levels affect the proliferation and migration of three cell lines.
  • While hydrophilic surfaces promote faster cell proliferation, increased stiffness enhances cell migration, spreading, and gene expression related to adhesion, suggesting critical insights for scaffold design in tissue engineering.
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Renal fibrosis results in the progressive renal dysfunction and leads to chronic kidney disease (CKD) and ultimately end-stage renal disease. Asiaticoside was reported to regulate synaptopodin, desmin, nephrin, and podocin levels in adriamycin-induced nephropathy of rats. In this study, we found out that asiaticoside inhibited renal fibrosis in vitro and in vivo.

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Objectives: This study aimed to (1) examine the cross-sectional and longitudinal relationships between depressive symptoms and health services utilization among Chinese middle-aged and older adults; and (2) evaluate whether there exists a rural-urban difference in such relationships.

Methods: Data was obtained from China Health and Retirement Longitudinal Study (CHARLS) in 2013 and 2015, a nationally representative survey of 13,551 adults aged 45 years and above in China.

Results: Depressive symptoms were positively associated with a greater likelihood of outpatient and inpatient health services utilization.

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Background: Ewing sarcoma, the second most frequent bone tumor in children and adolescents, is often presented with localized disease or metastatic-related symptoms. In this study, we aim to construct and validate a nomogram for patients with Ewing sarcoma to predict the 3- and 5-year overall survival (OS) based on the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: Demographic and clinic pathological characteristics of patients with Ewing sarcoma diagnosed between 2010 and 2015 were extracted from SEER database.

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Internet addiction among adolescents is an emerging public health issue. The aim of this study was to examine the relationship between being bullied and internet addiction, and further to test the mediating effect of adult attachments on this relationship among Chinese rural adolescents. A total of 1,270 adolescents from three high schools in Henan province were recruited as subjects.

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The nectar of Lindl. contains sugar, amino acids and other nutritional components, suggesting that it could be developed for food and food additives. To understand the effects of the nectar on human health, we investigated its chemical constituents.

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