Micron-scale heterogeneity reduction leads to increased interspecies competition in thermophilic digestion microbiome.

Microbial spatial heterogeneity is an important determinant of larger-scale community properties, whereas most studies neglect it and therefore only provide average information, potentially obscuring the signal of microbial interactions. Our study takes a step toward addressing this problem by characterizing the spatial heterogeneity of a microbiome with micron-scale resolution. Micron-scale single clusters (40-70 μm) were randomly collected from lab-scale anaerobic digestion (AD) biosystems, and a comparative analysis was performed to evaluate differences between mesophilic and thermophilic systems.

Rare disease publishing trends worldwide and in China: A CiteSpace-based bibliometric study.

This study aimed to understand research trends, determine frontier topics, and explore the developments in and the differences between research conducted in China and the rest of the world. We analyzed the research status of rare diseases in China and globally over the past decade using bibliometric methods. We focused on rare disease literature indexed in the Web of Science (WoS) and China National Knowledge Infrastructure (CNKI) databases from January 2013 to December 2023.

Beyond Batch Learning: Global Awareness Enhanced Domain Adaptation.

In domain adaptation (DA), the effectiveness of deep learning-based models is often constrained by batch learning strategies that fail to fully apprehend the global statistical and geometric characteristics of data distributions. Addressing this gap, we introduce "Global Awareness Enhanced Domain Adaptation" (GAN-DA), a novel approach that transcends traditional batch-based limitations. GAN-DA integrates a unique predefined feature representation (PFR) to facilitate the alignment of cross-domain distributions, thereby achieving a comprehensive global statistical awareness.

Effects of intergenerational feeding on the growth and development of infants aged 6-36 months: A cross sectional study.

This was an original article, mainly investigated the status and effects of intergenerational feeding of infants aged 6-36 months on their growth and development. The nutrition and development status of infants and toddlers were investigated by questionnaire. Logistic regression was employed to analyze whether intergenerational feeding was an independent factor for infant stunting and malnutrition.

Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B via IRBIT and L-IRBIT.

Nicotinamide adenine dinucleotide (NAD) is well known as a coenzyme involved in many redox reactions in cellular energy metabolism, or as a substrate for many NAD-consuming enzymes, including those that generate the second messenger cyclic ADP-ribose or deacetylate proteins (e.g., histones).

Associated factors of dental caries among middle-aged adults in Guizhou Province, China (2019-2020).

Background: The Fourth National Oral Health Epidemiological Survey (FNOHES) reported an 89% caries prevalence among adults aged 35-44 in China. This study explored the current prevalence and determinants of dental caries in Guizhou Province, where socioeconomic conditions have changed. We aimed to identify factors influencing dental caries to inform future oral health policies and preventive strategies tailored to the region.

Dual-Task Optimization Method for Inverse Design of RGB Micro-LED Light Collimator.

Miniaturized pixel sizes in near-eye digital displays lead to pixel emission patterns with large divergence angles, necessitating efficient beam collimation solutions to improve the light coupling efficiency. Traditional beam collimation optics, such as lenses and cavities, are wavelength-sensitive and cannot simultaneously collimate red (R), green (G), and blue (B) light. In this work, we employed inverse design optimization and finite-difference time-domain (FDTD) simulation techniques to design a collimator comprised of nano-sized photonic structures.

Corrigendum: Empagliflozin alleviates hepatic steatosis by activating the AMPK-TET2-autophagy pathway and .

[This corrects the article DOI: 10.3389/fphar.2020.

New insights into the mechanism of triphenyl phosphate and its metabolite diphenyl phosphate in diabetic kidney disease.

Diabetic kidney disease is a significant complication of diabetes mellitus, and exposure to certain chemicals may play a role in its development. Triphenyl phosphate (TPHP) is commonly used in plastics and flame retardants. This study aims to investigate the potential impact of TPHP and its metabolite diphenyl phosphate (DPHP) on diabetic kidney disease using various methods, including network toxicology, molecular docking, and cell experiments like CCK8 assay and real-time-PCR.

S-nitrosylation of peroxiredoxin 2 exacerbates hyperuricemia-induced renal injury through regulation of mitochondrial homeostasis.

Protein S-nitrosylation (SNO), a redox-based posttranslational modification of cysteine thiols, plays a crucial role in various signaling pathways. Peroxiredoxin 2 (PRDX2) is one of the most potent ROS scavenging proteins, providing protection against oxidative stress damage, with its function regulated by SNO. However, the precise role of SNO-PRDX2 in hyperuricemic nephropathy remains poorly understood.

Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling.

Abnormal angiogenesis is a key process associated with ischaemic retinopathies such as diabetic retinopathy, for which the underlying pathological mechanisms are still poorly understood. Here, we confirm that angiogenic factor 1 with a G patch and FHA domain (AGGF1) is elevated in the diabetics and induces retinal angiogenesis. Mechanistic investigations demonstrate that HIF-1α directly regulates AGGF1 expression.

Population profile and glycemic control following initiation or switch of injectable therapies in Tianjin, China: A real-world retrospective cohort study of adults with type 2 diabetes.

Aims: To evaluate characteristics and glycemic outcomes in individuals with type 2 diabetes using injectable therapies in real-world clinical practice in Tianjin, China.

Materials And Methods: Data from inpatients and outpatients receiving injectable therapies between January 2015 and December 2019 were collected from the Tianjin regional electronic medical records and retrospectively analyzed. Seven cohorts were identified, including individuals initiating injectable therapies (premixed insulin [n = 4,687], basal insulin [4,177], or glucagon-like peptide-1 receptor agonists [541]) or switching injectable therapies (premixed insulin to basal insulin [1,298], basal insulin to premixed insulin [1,457], basal insulin to basal + bolus insulin [1,772], or glucagon-like peptide-1 receptor agonists to basal insulin ± glucagon-like peptide-1 receptor agonists [82]).

Fatigue-Limit Assessment via Infrared Thermography for a High-Strength Steel.

Infrared thermography techniques have proven to be very effective for assessing the fatigue limits of metallic materials with obvious temperature variations. But for some materials, it has been shown that the temperature variation is very limited, and the accuracy of infrared thermographic techniques is not verified. In this study, the fatigue properties of a high-strength steel (SAE52100) were evaluated with traditional fatigue-loading techniques and infrared thermographic methods.

PRMT1-methylated MSX1 phase separates to control palate development.

Little is known about the regulation and function of phase separation in craniofacial developmental disorders. MSX1 mutations are associated with human cleft palate, the most common craniofacial birth defect. Here, we show that MSX1 phase separation is a vertebrate-conserved mechanism underlying embryonic palatal fusion.

Students as key allies in combating school bullying: Leveraging peer perspectives to recognize victimization in high-risk groups.

Bullying in schools remains a critical issue, and teachers often struggle to identify students at risk of victimization. This study explores the prevalence of various forms of bullying among high-risk groups in Taiwanese schools, using peer perspectives to gain insight. A total of 1,732 students (734 males and 998 females) participated in a survey that measured 10 common types of bullying, assessing both students' perceptions and the actual frequency of occurrences over the past 6 months.

Once-weekly IcoSema versus once-weekly semaglutide in adults with type 2 diabetes: the COMBINE 2 randomised clinical trial.

Aims/hypothesis: COMBINE 2 assessed the efficacy and safety of once-weekly IcoSema (a combination therapy of basal insulin icodec and semaglutide) vs once-weekly semaglutide (a glucagon-like peptide-1 analogue) 1.0 mg in individuals with type 2 diabetes inadequately managed with GLP-1 receptor agonist (GLP-1 RA) therapy, with or without additional oral glucose-lowering medications.

Methods: This 52 week, randomised, multicentre, open-label, parallel group, Phase IIIa trial was conducted across 121 sites in 13 countries/regions.

Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis.

Background: Astrocytes, the most abundant glial cell type in the brain, will convert into the reactive state in response to proteotoxic stress such as tau accumulation, a characteristic feature of Alzheimer's disease (AD) and other tauopathies. The formation of reactive astrocytes is partially attributed to the disruption of autophagy lysosomal signaling, and inhibiting of some histone deacetylases (HDACs) has been demonstrated to reduce the molecular and functional characteristics of reactive astrocytes. However, the precise role of autophagy lysosomal signaling in astrocytes that regulates tau pathology remains unclear.

Leveraging Multivalent Assembly towards High-Temperature Liquid-Phase Phosphorescence.

High-temperature phosphorescence (HTP) materials have attracted considerable attention owing to their expanded application prospects, whereas they still suffer from severe deactivation in polar media, limiting their reliability and utility. Here, we present an efficient multivalent assembly strategy to achieve high-temperature liquid-phase phosphorescence (HTLP). The supramolecular assembly of multivalent modules leads to extremely robust hydrogen-bonding networks, which firmly immobilize the organic phosphors and protect triplet excitons from annihilation in high-temperature polar media, resulting in excellent HTLP emission.

A Spatial Crowdsourcing Engine for Harmonizing Volunteers' Needs and Tasks' Completion Goals.

This work addresses the task allocation problem in spatial crowdsensing with altruistic participation, tackling challenges like declining engagement and user fatigue from task overload. Unlike typical models relying on financial incentives, this context requires alternative strategies to sustain participation. This paper presents a new solution, the Volunteer Task Allocation Engine (VTAE), to address these challenges.

Laboratory-simulated marine heatwave enhances physiological damage to mussels exposed to titanium dioxide nanoparticles by disrupting the gut-hepatopancreas axis.

The aggregation state of nano-TiO in the environment is altered under marine heatwaves (MHWs), thus affecting its bioavailability and toxicity to the marine organisms. Here, we investigated the toxic mechanisms and effects of nano-TiO on gut-hepatopancreas axis health of Mytilus coruscus exposed to 25 and 250 μg/L of nano-TiO under laboratory-simulated MHW. Compared with the control conditions or post-MHW cooling phase, prolonged MHW exposure significantly inhibited digestive function, decreased immune-related enzymes activities, and caused neurotoxicity in the mussels.

Quercetin attenuates the symptoms of osteoarthritis and by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling.

Osteoarthritis (OA) is a common joint disorder involving the cartilage and other joint tissues. Quercetin (QCT) serves a protective role in the development of OA. However, to the best of our knowledge, the regulatory mechanisms of QCT in the progression of OA have not yet been fully elucidated.

Efficacy and Safety of Janus Kinase Inhibitors in Patients with Vitiligo: A Systematic Review and Meta-Analysis.

Although several case reports and small clinical trials have reported promising outcomes with Janus kinase (JAK) inhibitors for vitiligo, high-quality evidence and guidelines are lacking. We evaluated the efficacy and safety of JAK inhibitors for the treatment of vitiligo using a meta-analysis of randomized controlled trials (RCTs). We searched the PubMed, Embase, and Cochrane Library databases up to August 2023, with additional studies from ClinicalTrials.

Improved glycaemic control in people with type 2 diabetes initiating or switching to IDegAsp in a real-world setting in China.

Aims: To investigate glycaemic control in Chinese adults with type 2 diabetes (T2D) initiating, or switching to insulin degludec/insulin aspart (IDegAsp), a co-formulation of basal, and bolus insulin, in a real-world setting.

Materials And Methods: A 20-week, prospective, single-arm, open-label, non-interventional study was conducted in Chinese adults with T2D initiating, or switching to IDegAsp after anti-hyperglycaemic treatment with oral antidiabetic drugs (OADs), other insulins, or glucagon-like peptide-1 receptor agonists. The primary endpoint was a change in HbA from baseline to end of the study; the secondary endpoints included a change in fasting plasma glucose and Diabetes Treatment Satisfaction Questionnaire (DTSQ) score.