Antibody-dependent enhancement of coronaviruses.

The COVID-19 pandemic presents a significant challenge to the global health and the world economy, with humanity engaged in an extended struggle against the virus. Notable advancements have been achieved in the development of vaccines and therapeutic interventions, including the application of neutralizing antibodies (NAbs) and convalescent plasma (CP). While antibody-dependent enhancement (ADE) has not been observed in human clinical studies related to SARS-CoV-2, the potential for ADE remains a critical concern and challenge in addressing SARS-CoV-2 infections.

Caffeine Sodium Benzoate Promotes Endothelial Dysfunction of Human Umbilical Vein Endothelial Cells by Promoting M1 Macrophage Polarization.

Our previous study uncovered that long-term abuse of caffeine sodium benzoate (CSB) could lead to dysfunction in human umbilical vein endothelial cells (HUVECs). However, the mechanism by which CSB induced endothelial dysfunction remains largely unstudied. CSB containing serum (CSB-CS) was collected from patients under long-term CSB inhalation.

Study of fluoroquinolones resistance in rifampicin-resistant tuberculosis patients in Beijing: Characteristics, trends, and treatment outcomes.

Background: China is a high-burden country for multidrug-resistant tuberculosis/rifampin-resistant tuberculosis (MDR/RR-TB). Fluoroquinolones (FQs) are key drugs for the treatment of patients with MDR/RR-TB. However, research on the resistance of FQs in Beijing is limited.

Accelerated solvent extraction of dioxins sequestered in activated carbon: A response surface methodology-based optimization.

Activated carbon (AC) is an effective sorbent for sequestering dioxin-like compounds, thereby reducing their bioavailability. Consequently, AC amendment is a promising tool for remediating dioxin-polluted soils, but tracking remediation results requires quantification of the dioxins sequestered within ACs. Standard methods for quantifying dioxins in soils are often unable to extract dioxins from AC, so the present study addresses this gap by optimizing an accelerated solvent extraction (ASE) method.

Attitudes Toward General Vaccination Mediate the Association Between Influenza Vaccination History and Pneumococcal Vaccination Intention Among Older Adults in China.

Influenza and pneumococcal vaccinations play a crucial role in disease prevention among older adults and are recommended to older adults aged 60 years and over in China, but the vaccination rates are suboptimal. Behavioral spillover indicates that a change in one behavior may lead to changes in other related behaviors. Based on the Behavioral Spillover Theory, this study aimed to investigate the association between influenza vaccination history and pneumococcal vaccination intention, as well as the mediating role of negative attitudes toward general vaccination among older adults in China.

Longitudinal relations among online social activities, peer relationship problems, and well-being in children: The moderating effect of extraversion.

Prior research has predominantly examined the relations between online social activities (OSA) and mental health among adolescents and adults, with comparatively less emphasis placed on children, particularly concerning positive indicators of subjective health, such as well-being. The relations between OSA and well-being are likely intricate and necessitate meticulously designed methodologies to investigate the associations and their underlying mechanisms. This longitudinal study employed the random intercept cross-lagged panel models to explore the dynamic relations between OSA and well-being, considering peer relationship problems as a potential mediator and extraversion as a moderator of the associations, while distinguishing between- and within-person effects.

Historical redlining and clustering of present-day breast cancer factors.

Purpose: Historical redlining, a 1930s-era form of residential segregation and proxy of structural racism, has been associated with breast cancer risk, stage, and survival, but research is lacking on how known present-day breast cancer risk factors are related to historical redlining. We aimed to describe the clustering of present-day neighborhood-level breast cancer risk factors with historical redlining and evaluate geographic patterning across the US.

Methods: This ecologic study included US neighborhoods (census tracts) with Home Owners' Loan Corporation (HOLC) grades, defined as having a score in the Historic Redlining Score dataset; 2019 Population Level Analysis and Community EStimates (PLACES) data; and 2014-2016 Environmental Justice Index (EJI) data.

The potential mechanisms and material basis of Fuzheng Jiedu decoction broad-spectrum inhibiting coronaviruses.

Traditional Chinese medicine has unique advantages in preventing and treating COVID-19, and Fuzheng Jiedu decoction (FZJDD) was reported to be effective against COVID-19 in clinical trials. To investigate the potential mechanisms and material basis of FZJDD against SARS-CoV-2, we performed SARS-CoV-2 target protein inhibition analyses and a metabolite full spectrum analysis of FZJDD. Interestingly, FZJDD was found to block the binding of SARS-CoV-2 Spike protein with the receptor ACE2 and inhibit the activity of SARS-CoV-2 3CLpro.

Dual-purpose elemental sulfur for capturing and accelerating biodegradation of petroleum hydrocarbons in anaerobic environment.

Hydrophobic organic pollutants in aqueous environments are challenging to biodegrade due to limited contact between microorganisms, the pollutants and the electron acceptor, particularly under anaerobic or anoxic conditions. Here, we propose a novel strategy that uses inexpensive, dual-function elemental sulfur (S) to enhance biodegradation. Using petroleum hydrocarbons as the target pollutants, we demonstrated that hydrophobic and nonpolar S° can concentrate hydrocarbons while simultaneously serving as an electron acceptor to enrich hydrocarbon-degrading bacteria.

Statistical methods for comparing two independent exponential-gamma means with application to single cell protein data.

In genomic study, log transformation is a common prepossessing step to adjust for skewness in data. This standard approach often assumes that log-transformed data is normally distributed, and two sample t-test (or its modifications) is used for detecting differences between two experimental conditions. However, recently it was shown that two sample t-test can lead to exaggerated false positives, and the Wilcoxon-Mann-Whitney (WMW) test was proposed as an alternative for studies with larger sample sizes.

Spatiotemporal dynamics of abstract concept processing: An MEG study.

Our current understanding of how linguistic concepts are represented and retrieved in the brain is largely based on studies using concrete language, and only few studies have focused on the neural correlates of abstract concepts. The role of the motor system, besides the classical language network, has been intensively discussed in action-related concrete concepts. To advance our understanding of spatiotemporal dynamics underlying abstract concept processing, our study investigated to what extent language and motor regions are engaged in the processing of abstract concepts vs.

Relations Between Psychological Maltreatment by Teachers and Cyberbullying Perpetration Among Elementary School Students: The Roles of Self-Esteem and Sex.

The topics of psychological maltreatment by teachers and children's cyberbullying perpetration have both attracted increasing research attention. However, clarification of the development and specific psychological mechanisms linking psychological maltreatment by teachers to cyberbullying perpetration by students remains necessary. Thus, this study examined the longitudinal relations between psychological maltreatment by teachers and subsequent cyberbullying perpetration, along with the mediating role of self-esteem and the moderating role of sex.

Childhood maltreatment profiles and their associations with trajectories of internalizing and externalizing symptoms in Chinese early adolescents.

Background: Childhood maltreatment is a risk factor for internalizing and externalizing symptoms in early adolescents. However, few studies have examined the associations between profiles of childhood maltreatment and trajectories of internalizing and externalizing symptoms in Chinese early adolescents.

Objectives: First, this study aimed to identify profiles of childhood maltreatment (i.

Longitudinal bidirectional relations between psychological maltreatment by teachers and psychosocial adjustment during early adolescence.

This study examined three models (relationship-driven model, symptom-driven model and transactional model) testing the across-time bidirectional relations between psychological maltreatment by teachers and early adolescents' psychosocial adjustment (i.e., internalizing problems, externalizing problems, and academic achievement) during early adolescence.

Associations between sedentary types, sedentary patterns and cognitive ability in preschool children.

Unlabelled: The preschool years are a critical period for developing cognitive abilities such as reasoning, memorization, comprehension, quick thinking, and problem-solving. Sedentary behavior (SB) is known to be associated with cognitive development in preschool children. However, limited research has focused on how different types of SB (active, passive) and sedentary patterns (bouts, breaks) affect preschool children's cognitive abilities.

Computer simulation help predict the frame deformation following a Venus-A transcatheter aortic valve implantation in patients with pure aortic regurgitation: a retrospective study.

Background: Patient-specific computer simulation of transcatheter aortic valve implantation (TAVI) predicts the interaction between an implanted device and the surrounding anatomy. In this study, we validated the predictive value of computer simulation for the frame deformation following a Venus-A TAVI implant in patients with pure aortic regurgitation (AR). Furthermore, we used the validated computational model to evaluate the anchoring mechanism within the same cohort.

Morphine promotes non-small cell lung cancer progression by downregulating E-cadherin via the PI3K/AKT/mTOR pathway.

Morphine has been suggested to affect cancer cell dynamics and decrease survival rates in lung cancer patients at specific doses, but the precise mechanisms poorly understood. In this study, we aimed to investigate the molecular mechanisms by which morphine modulates the malignant characteristics of non-small cell lung cancer. Cell proliferation was assessed via the Cell Counting Kit-8 assay, and cell migration and invasion were examined via wound healing and Transwell assays.

A carbon/oxygen calculation method to improve the response sensitivity of carbon/oxygen logging.

Carbon/Oxygen logging is an effective method to perform oil layer recognition and oil saturation calculation, which plays an important role in the evaluation of remaining oil after casing. At present, there are two main methods to calculate the ratio of carbon to oxygen (C/O). Compared with the energy window count method, the element yield method can avoid the influence of background count in the gamma spectrum and calculated carbon/oxygen value has the higher sensitivity and better accuracy, but it is still greatly affected by carbon and oxygen elements in the formation skeleton.

Developmental trajectories of loneliness in Chinese children: Environmental and personality predictors.

Background: This study aimed to identify the developmental trajectories of loneliness in Chinese children and examine the predictive roles of domain-specific environmental factors (i.e., family dysfunction and satisfaction of relatedness needs at school), personality factors (i.

Curcumin attenuates lupus nephritis by inhibiting neutrophil migration via PI3K/AKT/NF-κB signalling pathway.

Objective: To investigate the role of curcumin in the treatment of lupus nephritis (LN) by inhibiting the migration of neutrophils and the underlying mechanism involved.

Methods: Two lupus mouse models, MRL/lpr mice and R848-treated mice, were treated with 50 mg/kg curcumin by intraperitoneal injection. H&E and Masson staining were used to estimate histopathological changes in the kidney.