Publications by authors named "LiLe Zou"
Article Synopsis
- - Thrombocytopenia, a decrease in platelet count, is a significant issue in cancer treatment, as it hampers chemotherapy and radiation effectiveness. Ruxolitinib is being researched as a possible treatment option.
- - The study used various methods, including flow cytometry and animal models, to investigate how ruxolitinib affects the maturation of megakaryocytes (MKs) and its impact on thrombocytopoiesis in radiation-injured mice.
- - Results show that ruxolitinib enhances MK differentiation and recovery of platelet production, potentially by activating specific cellular pathways through its binding to TLR2, offering a promising new approach for treating thrombocytopenia.
Background: The offspring of pregnant women with gestational diabetes mellitus (GDM) are vulnerable to be glucometabolic disorders. However, to date, few current studies focused on the associations of maternal accumulated glucose exposure before delivery with neonatal glucometabolic disorders and large for gestational age (LGA) infants. This study is aimed at exploring the associations of maternal fructosamine (FMN) before delivery in GDM pregnant women with neonatal glucometabolic disorders in the first 3 days of life and LGA infants.
View Article and Find Full Text PDFBackground: is a famous traditional Chinese medicine (TCM) used to treat bleeding, rheumatism, lumbago, etc. However, its therapeutic effects and mechanism against thrombocytopenia are still unknown so far. In the study, we investigated the effects of aqueous extracts of (AECRs) against thrombocytopenia and its molecular mechanism.
View Article and Find Full Text PDFInverse correlations between serum bilirubin level and obesity had been reported in adults. We aimed to investigate the associations between neonatal hyperbilirubinemia and childhood obesity. Data was obtained from the U.
View Article and Find Full Text PDFMild hyperbilirubinemia is inversely associated with cardiometabolic diseases in adults. The aim of this study was to evaluate the association between neonatal serum bilirubin levels and childhood hypertension. Data were obtained from the U.
View Article and Find Full Text PDFBackground: Serum bilirubin levels are inversely associated with obesity in adults. We are interested in whether neonatal jaundice is associated with childhood obesity in preterm infants.
Methods: Data were obtained from the US Collaborative Perinatal Project.
In the present study, we aimed to explore gender differences in infant mortality and neonatal morbidity in mixed-gender twin pairs. Data were obtained from the US National Center for Health Statistics Linked Birth-Infant Death Cohort. A total of 108,038 pairs of mixed-gender twins were included in this analysis.
View Article and Find Full Text PDFAim: Selecting pathologic measures of placental inflammation that affect pregnancy and childhood health is largely empirical. We aimed to systematically select several core inflammation-related placental measures to construct a novel placental inflammatory evaluation criterion with a high prognostic relevance to child morbidity.
Methods: We used data from the US Collaborative Perinatal Project (1959-1976), a longitudinal birth cohort study that recruited women during pregnancy and followed the children until 7 years of age.