Prognostic Study of Intracranial Branch Atheromatous Disease in the Blood-supplying Areas of the Lenticulostriate and Paramedian Pontine Arteries.

Introduction: Branch atheromatous disease (BAD) is prone to early neurological deterioration (END), leading to a poor prognosis. The most common arteries causing END are the lenticulostriate arteries (LSA) and the paramedian pontine arteries (PPA). To gain insight into the characteristics of symptomatic plaques and their association with poor prognosis in patients with BAD, we conducted a prospective study using high-resolution magnetic resonance imaging (HRMRI).

Effects of liraglutide on abdominal fat distribution and glucose metabolism in Chinese subjects with obesity.

Aims: To observe the effects of liraglutide on abdominal fat distribution in Chinese subjects with obesity in 12 weeks, and further to explore the correlation between abdominal fat content and glucose metabolism after monotherapy.

Methods: This study recruited 71 obese subjects. All the subjects have received liraglutide monotherapy (0.

Polymerization-Achieved Cyclodextrin Slide-Ring Supramolecular Hydrogel Self-Generating Flexible Electronic Device.

Supramolecular flexible electronic devices are one of the research hotspots due to their application in the fields of chemistry, biology, and materials. Herein, we reported a slide-ring supramolecular flexible electronic device, which is constructed by acrylamide (AAm), acrylic acid (AA), carboxymethyl-α-cyclodextrin (CM-α-CD), PEG diacrylate (PEGDA), and calcium chloride via the photoinitiated polymerization, displaying not only the mechanical force-responded self-generation but also the human-computer information transfer. As compared with the polymer hydrogel, the addition of α-CD polypseudorotaxane to the hydrogel has notably enhanced both the tensile length and the tensile toughness, making it more suitable for flexible electronic device applications.

Development and Testing of a Multi-Component Intervention to Improve Medication Literacy in Glaucoma Patients.

Objective: To develop a medication literacy intervention program for glaucoma and test its effects on medication literacy, medication self-efficacy and medication adherence.

Methods: The intervention was constructed according to the Information-Motivation-Behavioral skills Model and the Health Belief Model. Preliminary protocols were revised through expert group meetings and pre-experiments to form a formal intervention plan.

Novel loci for triglyceride/HDL-C ratio longitudinal change among subjects without T2D.

Triglyceride (TG)/HDL-C ratio (THR) is a surrogate predictor of hyperinsulinemia. To identify novel genetic loci for THR change over time (ΔTHR), we conducted genome-wide association study (GWAS) and genome-wide linkage scan (GWLS) among nondiabetic Europeans from the Long Life Family Study (n = 1,384). Subjects with diabetes or on dyslipidemia medications were excluded.

The transcription factor Dof3.6/OBP3 regulates iron homeostasis in Arabidopsis.

Iron is an essential element for plants. Iron uptake by plants is highly regulated, but the underlying mechanism is poorly understood. Using a truncated fragment of the iron deficiency-responsive bHLH100 gene promoter, we screened the Arabidopsis transcription factor yeast one-hybrid (Y1H) library and identified the DOF family protein, OBP3, as a crucial component of the iron deficiency-signaling pathway.

Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease.

The integration of quantitative trait loci (QTLs) with disease genome-wide association studies (GWASs) has proven successful in prioritizing candidate genes at disease-associated loci. QTL mapping has been focused on multi-tissue expression QTLs or plasma protein QTLs (pQTLs). We generated a cerebrospinal fluid (CSF) pQTL atlas by measuring 6,361 proteins in 3,506 samples.

Long-term efficacy and safety of stapokibart for moderate-to-severe atopic dermatitis: 52-week results from a phase 3 trial.

Background: Management of moderate-to-severe atopic dermatitis (AD) needs long-term therapy. Stapokibart is a humanized monoclonal antibody targeting interleukin-4 receptor α subunit (IL-4Rα), a shared receptor for IL-4 and IL-13 which are key pathogenic drivers of AD. In a pivotal phase 3 trial (NCT05265923), significant higher proportions of adult AD patients receiving stapokibart than placebo achieved ≥75% improvement from baseline in Eczema Area and Severity Index (EASI-75; 66.

Association mapping identifies stable loci containing novel genes for developmental and reproductive traits in sorghum.

We mapped 11 sorghum traits, identified 33 candidate genes, and found a grain yield gene () that regulates seed development and a grass-specific tillering gene (DUF1618) transferred to .

Design of a High-Power Nanosecond Electromagnetic Pulse Radiation System for Verifying Spaceborne Detectors.

The Spaceborne Global Lightning Location Network (SGLLN) serves the purpose of identifying transient lightning events occurring beneath the ionosphere, playing a significant role in detecting and warning of disaster weather events. To ensure the effective functioning of the wideband electromagnetic pulse detector, which is a crucial component of the SGLLN, it must be tested and verified with specific signals. However, the inherent randomness and unpredictability of lightning occurrences pose challenges to this requirement.

Rational design of monodispersed Au@Pt core-shell nanostructures with excellent peroxidase-mimicking activity for colorimetric detection of Cr(VI).

Cr(VI) is one of the most typical heavy metal contaminants and rapid detection of Cr(VI) is highly important in food control and public health. Herein, a core-shell Au@Pt nanozyme-based colorimetric assay was developed for the rapid and sensitive detection of Cr(VI). The monodispersed Au@Pt core-shell nanoparticles exhibited high peroxidase-mimicking activity and can catalyze colorless TMB into blue-colored oxidized oxTMB.

Mechanism of LMNB1 activating GPR84 through JAK-STAT pathway to mediate M2 macrophage polarization in lung cancer.

Background: It is reported that G protein-coupled receptor 84 (GPR84) can participate in inflammation and immune regulation to repress anti-tumor responses. However, the function of GPR84 in lung cancer (LC) and its potential molecular mechanisms are still largely unknown.

Methods: Bioinformatics and molecular experiments were employed to assess the expression of GPR84 in LC.

Effects of γ-Aminobutyric Acid on Growth Performance, Immunity, Antioxidant Capacity, and Intestinal Microbiota of Growing Minks.

The present experiment was conducted to investigate the effects of γ-aminobutyric acid (GABA) on the growth performance, immunity, antioxidant capacity, and intestinal microbiota of growing minks. One hundred minks were evenly allocated across five groups, with each group consisting of 10 males and 10 females. The minks in these groups were fed a basal diet supplemented with γ-aminobutyric acid (GABA) at 0 (control), 10, 20, 30, and 40 mg/kg of diet, respectively.

Nanotechnology-Enabled PCR with Tunable Energy Dynamics.

This Perspective elucidates the transformative impacts of advanced nanotechnology and dynamic energy systems on the polymer chain reaction (PCR), a cornerstone technique in biomedical research and diagnostic applications. Since its invention, the optimization of PCR-specifically its efficiency, specificity, cycling rate, and detection sensitivity-has been a focal point of scientific exploration. Our analysis spans the modulation of PCR from both material and energetic perspectives, emphasizing the intricate interplay between PCR components and externally added entities such as molecules, nanoparticles (NPs), and optical microcavities.