Bavachin stimulates ferroptosis and reduces malignant phenotype progression of hepatocellular carcinoma cells by inducing lipid peroxidation by modulation of the Nrf2/HO-1 signaling pathway.

Background: The mechanism of ferroptosis is primarily driven by the iron-dependent lethal accumulation of membrane lipid peroxidation. Bavachin has been found to exacerbate lipid peroxidation in cancer cells; however, whether it hinders hepatocellular carcinoma (HCC) progression by way of ferroptosis remains unknown.

Methods: Cell counting kit-8 (CCK-8) assay was used to measure the effect of Bavachin on the viability of HCC cells, so as to determine the appropriate drug concentration for subsequent experiments.

Latent Profile Analysis and Determinants of Marital Adjustment in Patients with Breast Cancer.

Objective: The aim of this study is to assess the latent profile types of marital adjustment in patients with breast cancer and to analyze the factors influencing these various profiles.

Methods: Patients with breast cancer who visited the Breast Surgery Department from January to June 2023 were selected using convenience sampling. These patients were surveyed using a general data questionnaire, the Revised Dyadic Adjustment Scale (RDAS), the Interpersonal Reactivity Index-C (IRI-C), and the Emotional Regulation Self-Efficacy Scale (RESS).

The role of empathy and emotional regulation self-efficacy in adult attachment type and marital adjustment in breast cancer patients-a moderated mediation model.

To date, previous research has elucidated the impact of adult attachment type on marital relationships. However, the mechanisms underpinning the relationship between attachment type and marital adjustment in breast cancer patients remain unclear. In this study, a cohort of 272 breast cancer patients was surveyed using several instruments: the General Information Questionnaire, Revised Marital Adjustment Scale (RDAS), Adult Attachment Scale (AAS), Interpersonal Reactivity Indicator Scale (IRI), and Regulated Emotional Self-Efficacy Scale (RESS).

Brass wire ligation for treatment of the ectopic eruption of the mandibular second molar: a case report.

Ectopic eruption of the second permanent molar is a tooth replacement disorder during adolescence. If not treated in time, it can cause hard tissue of the adjacent first molar resorption, early tooth loss, decreased chewing efficiency, and other serious malocclusions. Timely detection and treatment of ectopic eruption of the second permanent molar are of great significance in preventing malocclusions in adolescents and establishing normal occlusion relationships.

High expression of SLC27A2 predicts unfavorable prognosis and promotes inhibitory immune infiltration in acute lymphoblastic leukemia.

Solute carrier family 27 member 2 (SLC27A2) is involved in fatty acid metabolism in tumors and represents a prospective target for cancer therapy. However, the role and mechanism of action of SLC27A2 in acute lymphoblastic leukemia (ALL) remain unclear. In this study, we aimed to explore the intrinsic associations between SLC27A2 and ALL and evaluate the prognostic significance, biological functions, and correlation with immune infiltration.

High-precision 3D printing of multi-branch vascular scaffold with plasticized PLCL thermoplastic elastomer.

Three-dimensional (3D) printing has emerged as a transformative technology for tissue engineering, enabling the production of structures that closely emulate the intricate architecture and mechanical properties of native biological tissues. However, the fabrication of complex microstructures with high accuracy using biocompatible, degradable thermoplastic elastomers poses significant technical obstacles. This is primarily due to the inherent soft-matter nature of such materials, which complicates real-time control of micro-squeezing, resulting in low fidelity or even failure.

Unveiling of the Resistive Switching Mechanism of Halide Perovskite-Based Memristors.

The organic-inorganic halide perovskite has become one of the most promising candidates for next-generation memory devices, i.e. memristors, with excellent performance and solution-processable preparation.

Influence of different caregiving styles on fundamental movement skills among children.

Purpose: This study investigated the influence of parenting and grandparenting caregiving styles on fundamental motor skills (FMS) of preschool children.

Method: A total of 1,326 preschool children (698 boys, 628 girls) aged 4-6 years were recruited from the kindergartens of Jinhua City, China. Locomotor skills (LM), ball skills (BS), and total fundamental movement skills (TS) of children were assessed by the Test of Gross Motor Development-3rd edition (TGMD-3).

Investigation of the temperature gradient control in the printing space for the material extrusion of medical biodegradable hydrogel.

Material extrusion has shown promise in the fabrication of biocompatible scaffolds for tissue engineering using medical biodegradable hydrogel materials. However, the uncontrollable shape of prepared 3D architecture decelerates the development of large-size complex hydrogel models for the fabrication of human-scale tissue or organs. A primary cause of the collapse as well as shrinkage of prepared architectures is the uncontrollable ambient temperature distribution during the extruding process for hydrogel materials.

Computational investigation of a 3D-printed skin substitute with orthotropy in mechanical property.

As a promising treatment for third-degree burns, grafting with bioengineering skin substitutes shows a capability to overcome the deficiency of donor skin. Similar mechanical properties with human skin are required for employed skin substitutes to avoid secondary damage to patients. Given the representativeness of orthotropy in mechanical properties, there is a need for developing orthotropic skin substitutes.

Highly Active Single-Atom Nanozymes with High-Loading Iridium for Sensitive Detection of Pesticides.

Single-atom nanozymes (SAzymes) are novel mimic-enzyme materials with atomically doped active sites. They play a pivotal role in the field of nanozymes because of their excellent catalytic activities, high utilization efficiency of the metal atoms, and simple model of active sites. Herein, the peroxidase (POD)-like SAzymes with high-loading iridium (Ir) (5.

All-solution-processed perovskite/gallium nitride particles hybrid visible-blind ultraviolet photodetectors.

Last decades have witnessed the rapid development of ultraviolet (UV) photodetectors in diversity of applications. The III-nitride semiconductor and metal halide perovskite have both performed promising UV-sensing optoelectronic properties. However, they are still suffering from either the high temperature epitaxial-growth or low photocurrent generated in UV range.

Surface Cleanliness Maintenance with Laminar Flow Based on the Characteristics of Laser-Induced Sputtering Particles in High-Power Laser Systems.

In high-power laser systems, the primary cause of contamination of optical components and degradation of spatial cleanliness is laser-induced sputtering of particles. To mitigate this problem, laminar flow is frequently utilized to control the direction and transport of these particles. This study characterizes the properties of laser-induced sputtering particles, including their flying trend, diameter range, and velocity distribution at varying time intervals.

Influence of reactive oxygen species concentration and ambient temperature on the evolution of chemical bonds during plasma cleaning: a molecular dynamics simulation.

The research on plasma chemistry involved in the formation and dissociation of abundant chemical bonds is fundamental to developing plasma cleaning. To understand the influence of reactive oxygen species' concentration and ambient temperature on the evolution behavior of the chemical bond during plasma cleaning, microscopic reaction models between organic contaminants and reactive oxygen species were established and performed by reactive molecular dynamics. Dibutyl phthalate, as a representative organic contaminant, was selected as the research object.

Exploring the fluorescence enhancement of the split G-quadruplex towards DNA-templated AgNCs and their application in omethoate detection.

Herein, the fluorescent enhancement of the split G-quadruplex (G4) towards DNA-templated AgNCs (DNA-AgNCs) was systematically studied. It was shown that the two G-rich probes with the ratio of the guanine (G) bases of 6 : 6 was the best split mode, and the spacer length of the zero T base at both two sides could present the optimal distance between the AgNCs and split G4. In light of these results, a split G4 coupled with DNA-AgNCs for omethoate (OME) detection was successfully fabricated.

Investigation on the Temperature Distribution Uniformity of an Extrusion-Based 3D Print Head and Its Temperature Control Strategy.

Extrusion-based 3D printing for thermoplastic polymers manifests potential for the fabrication of biocompatible and biodegradable scaffolds. However, the uncontrollable shape of printed filaments usually negatively impacts on the printing processes. Non-uniform temperature in the print head is a primary cause of inaccuracy in the diameter of filaments formed during the process of extruding thermoplastic polymers.

LPS activates neuroinflammatory pathways to induce depression in Parkinson's disease-like condition.

This study aimed to observe the effects of lipopolysaccharide (LPS) intraperitoneal (i.p.) injection on rats and investigate how neuroinflammation contributes to the pathogenesis of depression in Parkinson's disease (dPD).

Diagnostic value of reflux episodes in gastroesophageal reflux-induced chronic cough: a novel predictive indicator.

Background: Multichannel intraluminal impedance and pH-monitoring (MII-pH) is an essential testing modality for gastroesophageal reflux-induced chronic cough (GERC), while the existing diagnostic criteria still have some inherent defects. This study aimed to explore the diagnostic value of a direct and objective index, reflux episodes, and related parameters in MII-pH in different types of GERC.

Methods: Patients with chronic cough suspected of gastroesophageal reflux disease who successfully received MII-pH were enrolled.

Investigation on the Temperature Control Accuracy of a Print Head for Extrusion 3D Printing and Its Improved Design.

For the extrusion 3D printing process, the printing temperature has a significant impact on the filament formation process because the rheological properties of the printed materials are extremely thermal sensitive, which requires a high temperature control accuracy of the print head. This paper presents a numerical and experimental investigation on the temperature field of a homemade print head. A finite element simulation model for analyzing the temperature field of the print head was established, by which the temperature distribution inside the print head can be acquired.

Analysis of the Effect of Exercise Combined with Diet Intervention on Postoperative Quality of Life of Breast Cancer Patients.

To analyze the effect of exercise combined with diet intervention on postoperative quality of life of breast cancer patients, a total of 104 breast cancer patients randomly selected from October 2019 to September 2020 who received systemic adjuvant endocrine drug therapy in our hospital for the first time were divided into the observation group and control group as the research subjects. The control group was given exercise and exercise intervention on the basis of routine nursing, and the observation group was given exercise and exercise combined with diet intervention on the basis of basic nursing. Nutritional indexes, anxiety and depression, sleep quality, cancer-induced fatigue, and life quality were observed in both groups.

Ratiometric detection of transcription factor based on Europium(III) complex-doped silicon nanoparticles and a G-quadruplex-selective Iridium(III) complex.

To sensitively detect transcription factor (TF) in complicated biological systems, a ratiometric luminescent detection system based on europium(III) complex-doped silicon nanoparticles (SiNPs) and a G-quadruplex (G4)-selective iridium(III) complex has been successfully constructed. During the biosensor fabrication, the G-rich hairpin DNA H1 was immobilized on the surface of SiNPs which was doped with the europium(III) complex Eu(III)(EDTA)(DPA). The dsDNA (S1/S2) contains TF recognition site, and one of its ssDNA S2 is protected by TF from the digestion of exonuclease III (Exo III).

A Process Parameter Design Method for Improving the Filament Diameter Accuracy of Extrusion 3D Printing.

Process parameters have a significant impact on the filament diameter of extrusion 3D printing. To precisely control filament diameter, this paper proposes a novel method based on experiments to guide process parameter design. Additionally, an extrusion 3D printing device was developed, by which the influence of crucial process parameters and rheological properties on the diameter of printed filaments could be investigated experimentally and theoretically.