Publications by authors named "Li-zhong Han"

The composition of volatile compounds in beer is crucial to the quality of beer. Herein, we identified 23 volatile compounds, namely, 12 esters, 4 alcohols, 5 acids, and 2 phenols, in nine different beer types using GC-MS. By performing PCA of the data of the flavor compounds, the different beer types were well discriminated.

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The development of food-derived Xanthine Oxidase (XO) inhibitors is critical to the treatment of hyperuricemia and oxidative stress-related disease. Few studies report on milk protein hydrolysates' XO inhibitory activity, with the mechanism of their interaction remaining elusive. Here, different commercial enzymes were used to hydrolyze α-lactalbumin and bovine colostrum casein.

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Research indicates that Staphylococcus aureus colonization in the elderly with predisposing risks is associated with subsequent infection. However, the molecular epidemiology and risk factors for S. aureus colonization among residents and staff in nursing homes (NHs) in China remain unclear.

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Article Synopsis
  • The study examines the rising incidence of Candida bloodstream infections (BSIs) over 11 years at a large hospital in Shanghai and analyzes risk factors for mortality and the effects of antifungal treatments.
  • Out of 370 patients with 393 BSI episodes, a 28.5% mortality rate was recorded, which was notably lower for those who received antifungal therapy compared to those who did not.
  • Notable independent risk factors for 28-day mortality included age, chronic renal failure, mechanical ventilation, and severe neutropenia, highlighting the importance of timely antifungal intervention.
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The serotype and antimicrobial resistance of in adult patients have changed due to the application of antimicrobials and type b (Hib) vaccine worldwide. However, the epidemiologic characteristics of in Shanghai are still unavailable. To determine the serotype distribution, antimicrobial resistance and multilocus sequence type (MLST) of in adult patients in Shanghai.

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, a main causative agent associated with invasive and non-invasive infection in elderly population, is a major global health problem. After pneumococcal conjugate vaccines (PCV) and pneumococcal polysaccharide vaccines (PPV) were introduced, the distribution of serotypes has changed. There was currently limited data on epidemiology and status of antimicrobial resistance of in Shanghai.

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Surveillances and interventions on antibiotics use have been suggested to improve serious drug-resistance worldwide. Since 2007, our hospital have proposed many measures for regulating surgical prophylactic antibiotics (carbapenems, third gen. cephalosporins, vancomycin, etc.

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Background: Enterobacter cloacae is a major nosocomial pathogen causing bloodstream infections. We retrospectively conducted a study to assess antimicrobial susceptibility and phylogenetic relationships of E. cloacae bloodstream isolates in two tertiary university-affiliated hospitals in Shanghai, in order to facilitate managements of E.

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or methicillin-resistant (MRSA) is a major pathogen causing pneumonia among children. To estimate the prevalence and molecular properties of in children pneumonia in Shanghai, China, 107 hospitalized children with pneumonia from two children's hospitals from January 2014 through June 2015 were studied. isolates from the respiratory specimens were characterized by antimicrobial susceptibility, typing, toxin genes, multilocus sequence typing (MLST), , and SCCmec typing.

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(.pneumoniae) is a common nosocomial pathogen causing bloodstream infections. Antibiotic susceptibility surveillance and molecular characterization will facilitate prevention and management of bloodstream infections.

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Background: Staphylococcus aureus is one of the predominant causes of skin and soft tissue infections (SSTIs), but limited data were available regarding the characterization of S. aureus from SSTIs patients in Jiangsu Province in China. We aimed to investigate the molecular epidemiology of S.

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The aim of the study was to investigate the resistant mechanisms and homology of imipenem-resistant Acinetobacter baumannii (A. baumannii). A total of 46 non-duplicate imipenem‑resistant A.

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Background: Cardiac rehabilitation (CR) protocols have diversified to include home-based cardiac tele-rehabilitation (HBCTR) as an alternative to hospital-based or center-based CR. To adopt the use of home-based cardiac tele-rehabilitation, it is necessary to assess cardiac patients' attitudes towards acceptance of such e-health technology, especially in China where knowledge of such technology is deficient.

Methods: Interviews were conducted in the First Affiliated Hospital of Shantou University Medical College, Shantou, China.

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Article Synopsis
  • Nursing home residents in Shanghai are at a high risk for methicillin-resistant Staphylococcus aureus (MRSA) carriage, with a study showing 10.2% of 443 residents tested positive for MRSA.
  • Key risk factors include previous hospitalization, presence of invasive devices, and certain antibiotic therapies like chloramphenicol and macrolides, suggesting the need for targeted infection control measures.
  • The findings highlight the necessity for improved infection control strategies in nursing homes to combat MRSA prevalence, ensuring both convenience and effectiveness in their implementation.
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Article Synopsis
  • E. coli is a major cause of bloodstream infections, prompting a study on its antimicrobial resistance in three Shanghai hospitals between Sept 2013 and Sept 2014.
  • A total of 90 isolates were analyzed for susceptibility, revealing high resistance rates (>60%) for several antibiotics, and the prevalence of extended-spectrum beta-lactamases (ESBLs) among the strains studied.
  • Phylogenetic analysis showed that the most common sequence type was ST131, primarily belonging to group B2, which also had the highest ESBL production, indicating a need for ongoing surveillance to prevent spread.
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Background: Residents in nursing homes (NHs) always represent potential reservoirs for Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). To our knowledge, there is no epidemiological information up till now that describes the prevalence and molecular characteristics of S.

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Background: Staphylococcus aureus is one predominant cause of skin and soft-tissue infections (SSTIs), but little information exists regarding the characterization of S. aureus from non-native patients with SSTIs in China.

Methods: In this study, we enrolled 52 non-native patients with S.

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Background: Staphylococcus aureus or methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of surgical site infections (SSIs). The aim of our study was to characterize molecularly S. aureus isolates from SSIs in orthopedic patients in Shanghai, China.

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Background: Prevention and management of Escherichia coli bloodstream infections (EC-BSIs) have become increasingly complicated by antimicrobial resistance and rapid dissemination. We investigated the antimicrobial epidemiology and phylogenetic background of clinical E. coli isolates from patients with bloodstream infections in Shanghai from 2011 to 2013.

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Background: Trials on sling exercise (SE), commonly performed to manage chronic low back pain (LBP), yield conflicting results. This study aimed to review the effects of SE on chronic LBP.

Methods: The randomized controlled trials comparing SE with other treatments or no treatment, published up to August 2013, were identified by electronic searches.

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Objectives: Staphylococcus aureus or methicillin-resistant Staphylococcus aureus (MRSA) has been an important pathogen causing bloodstream infections. Our study aimed to investigate the epidemiological and genetic diversity of clinical S. aureus isolates from patients with bloodstream infection in four hospitals of Shanghai from 2009 to 2011.

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Background: Multidrug-resistant Acinetobacter baumannii (MDRAB) is an important and emerging hospital-acquired pathogen worldwide. This study was conducted to identify the sources of MDRAB and its role in respiratory tract colonization and nosocomial pneumonia in intensive care unit (ICU) patients.

Methods: We conducted a prospective active surveillance study of MDRAB in three ICUs at a Chinese Hospital from April to August 2011, to identify the sources of MDRAB and its role in respiratory tract colonization and nosocomial pneumonia.

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Staphylococcus aureus has been a major cause of hospital-acquired infections. Methicillin-resistant Staphylococcus aureus (MRSA) has emerged since 1980s as an epidemiologic problem in hospitals. This old pathogen brings a new challenge to all physicians and bacteriologists.

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As a large number of multidrug-resistant bacteria have emerged, and there is an urgent need for the development of new antibacterial agents. In this study, we developed a liquid-based slow killing assay to be carried out in standard 96-well microtiter plates. This screening method was designed to facilitate high-throughput screening of small molecules and extracts.

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