[Evaluation of the preclinical teaching effects of digital virtual simulation system in veneer tooth preparation].

Purpose: To evaluate the preclinical teaching effects of digital virtual simulation system applied in window-type veneer tooth preparation of undergraduate dental students.

Methods: In the early clinical exposure of five-year undergraduate students from School of Stomatology, Fudan University, Simodont virtual simulation system and conventional phantom-simulator system were alternatively used in the preclinical teaching of veneer tooth preparation. First, after theoretical training and tests of veneer tooth preparation, twenty-three students were randomly divided into two groups.

Research Progress on Detection of New Psychoactive Substance Piperazines .

Piperazines are a class of new psychoactive substances with hallucinogenic effects that affect the central nervous system by affecting the level of monoamine neurotransmitters. Abuse of piperazines will produce stimulating and hallucinogenic effects, accompanied by headache, dizziness, anxiety, insomnia, vomiting, chest pain, tachycardia, hypertension and other adverse reactions, and may even cause cardiovascular diseases and multiple organ failure and lead to death, seriously affecting human physical and mental health and public safety. The abuse of new psychoactive substance piperazines has attracted extensive attention from the international community.

Fufang Luohanguo Qingfei granules reduces influenza virus susceptibility via MAVS-dependent type I interferon antiviral signaling.

Ethnopharmacological Relevance: Fufang Luohanguo Qingfei granules (LQG) is a Chinese patent medicine, clinically used to treat flu-like symptoms including cough with yellow phlegm, impeded phlegm, dry throat and tongue. However, the protective activity of LQG against influenza infection is indeterminate.

Aim Of The Study: This study is to investigate the therapeutic effect of LQG on influenza infection and elucidate its underlying mechanism.

Thiacalix[4]arene-Protected Silver Nanoclusters Encapsulating Different Two-Electron Superatom Oligomers.

The subvalent silver kernel represents the nascent state of silver cluster formation, yet the growth mechanism has long been elusive. Herein, two silver nanoclusters ( and ) coprotected by TC4A (HTC4A = --butylthiacalix[4]arene) and TBPMT (TBPMTH = 4--butylbenzenemethanethiol) containing 6e and 4e silver kernels are synthesized and characterized. The trimer of the 2e superatom Ag kernel in is built from a central Ag octahedron sandwiched by two orthogonally oriented Ag trigonal bipyramids through sharing vertexes, whereas a double-octahedral Ag kernel in is a dimer of 2e superatoms.

The incidence and predisposing factors for irritable bowel syndrome following COVID-19: a systematic review and meta-analysis.

Background: Irritable bowel syndrome (IBS) is a common functional gastrointestinal (GI) disorder. Several studies have analyzed the long-term GI symptoms and IBS following coronavirus disease 2019 (COVID-19). The purpose of this study is to evaluate the incidence and predisposing factors for IBS following COVID-19 by a systematic review and meta-analysis.

The cultural policies of schistosomiasis control in China: a historical analysis.

China has a history of using cultural policies to control infectious diseases, including schistosomiasis, which was once hyperendemic in the country. Since the founding of the People's Republic of China, significant achievements have been made in schistosomiasis control, with a decrease in the number of cases and infection rates. This study provides a historical analysis of cultural policies in schistosomiasis control in China.

Monoarsine-protected icosahedral cluster [Au(AsPh)Cl]: comparative studies on ligand effect and surface reactivity with its stibine analogue.

Ligand shells of gold nanoclusters play important roles in regulating their molecular and electronic structures. However, the similar but distinct impacts of the homologous analogues of the protecting ligands remain elusive. The symmetric monoarsine-protected cluster [Au(AsPh)Cl] (AuAs) was facilely prepared by direct reduction of (PhAs)AuCl with NaBH.

Ag Nanoclusters with Thermally Activated Delayed Fluorescence Protected by Ag/Cyanurate/Phosphine Metallamacrocyclic Monolayers through In-Situ Ligand Transesterification.

The composition of protection monolayer exerts great influence on the molecular and electronic structures of atomically precise monolayer protected metal nanoclusters. Four isostructural Ag/cyanurate/phosphine metallamacrocyclic monolayer protected Ag nanoclusters are synthesized by kinetically controlled in-situ ligand formation-driven strategy. These eight-electron superatomic silver nanoclusters feature an unprecedented interfacial bonding structure with diverse E-Ag (E=O/N/P/Ag) interactions between the Ag core and metallamacrocyclic monolayer, and displays thermally activated delayed fluorescence (TADF), benefiting from their distinct donor-acceptor type electronic structures.

Nuclearity enlargement from [PWO@Ag] to [(PWO)@Ag] and 2D and 3D network formation driven by bipyridines.

The structural transformations of metal nanoclusters are typically quite complex processes involving the formation and breakage of several bonds, and thus are challenging to study. Herein, we report a case where two lacunary Keggin polyoxometallate templated silver single-pods [PWO@Ag] (SD/Ag51b) fuse to a double-pod [(PWO)@Ag] by reacting with 4,4'-bipyridine (bipy) or 1,4-bis(4-pyridinylmethyl)piperazine (pi-bipy). Their crystal structures reveal the formation of a 2D 4-sql layer (SD/Ag72a) with bipy and a 3D pcu framework (SD/Ag72c) with pi-bipy.

Toward Controlled Syntheses of Diphosphine-Protected Homochiral Gold Nanoclusters through Precursor Engineering.

Controllable syntheses of Au nanoclusters (NCs) with different nuclearities are of great significance due to the kernel-dependent physicochemical properties. Herein, two pairs of enantiomeric Au NCs [Au(/-BINAP)(PhC≡C)Cl] () and [Au(/-BINAP)(PhC≡C)]·Cl (), both with (rigid axial chirality) diphosphine BINAP (2,2'-bis(diphenylphosphino)-1,1'-binaphthalene) as the predominant organic ligands, were controllably synthesized through precursor engineering. The former was obtained by direct reduction of HAuCl·4HO, while the latter was obtained by reduction of [Au(SMe)Cl] instead.

Revealing the chirality origin and homochirality crystallization of Ag nanocluster at the molecular level.

Although chirality is an ever-present characteristic in biology and some artificial molecules, controlling the chirality and demystifying the chirality origin of complex assemblies remain challenging. Herein, we report two homochiral Ag nanoclusters with inherent chirality originated from identical rotation of six square faces on a Ag cube driven by intra-cluster π···π stacking interaction between pntp (Hpntp = p-nitrothiophenol) ligands. The spontaneous resolution of the racemic (SD/rac-Ag14a) to homochiral nanoclusters (SD/L-Ag14 and SD/R-Ag14) can be realized by re-crystallizing SD/rac-Ag14a in acetonitrile, which promotes the homochiral crystallization in solid state by forming C-H···O/N hydrogen bonds with nitro oxygen atoms in pntp or aromatic hydrogen atoms in dpph (dpph = 1,6-bis(diphenylphosphino)hexane) on Ag nanocluster.

Perfluorodecanoic acid induces meiotic defects and deterioration of mice oocytes in vitro.

Perfluorodecanoic acid (PFDA) is a member of the perfluoroalkyl substances, which are toxic to organic functions. Recently, it has been found in follicular fluid, seriously interfering with reproduction. Follicular fluid provides the oocyte with necessary resources during the process of oocytes maturation.

A comparative study on atomically precise Au nanoclusters as catalysts for the aldehyde-alkyne-amine (A) coupling reaction: ligand effects on the nature of the catalysis and efficiency.

Atomically precise Au nanoclusters stabilized by stibines catalyze the aldehyde-alkyne-amine coupling reaction more efficiently than those stabilized by thiols or phosphines. The nature of the catalytic activity is also different, and may be attributed to the weaker coordinating ability of the stibine ligands.

Pseudomonas bacteriocin syringacin M released upon desiccation suppresses the growth of sensitive bacteria in plant necrotic lesions.

Bacteriocins are regarded as important factors mediating microbial interactions, but their exact role in community ecology largely remains to be elucidated. Here, we report the characterization of a mutant strain, derived from Pseudomonas syringae pv. tomato DC3000 (Pst), that was incapable of growing in plant extracts and causing disease.

Stibine-protected Au nanoclusters: syntheses, properties and facile conversion to GSH-protected Au nanocluster.

Monostibine-protected ionic Au nanoclusters, namely, [Au(L)(Cl)][Cl] (L= SbPh, ·Cl; Sb(-tolyl), ·Cl) were prepared by the direct reduction of Au(L)Cl with NaBH in dichloromethane. Anion exchange with ·Cl afforded [Au(SbPh)(Cl)][X] (X = PF, ·PF; BPh, ·BPh). All these have been characterized by multinuclear NMR, ESI-MS and UV-Vis spectroscopy.

Regulatory Role of Endothelial PHD2 in the Hepatic Steatosis.

Background/aims: Liver disease is a leading cause of high mortality and morbidity worldwide. The aim of the present study is to investigate the regulatory role of prolyl hydroxylase-2 (PHD2)-hypoxia-inducible factor-2a (HIF-2α) axis on nonalcoholic fatty liver disease (NAFLD) and to explore the potential mechanisms by which endothelial (EC)-specific PHD2 deficiency regulates hepatic steatosis and fibrosis.

Methods: In the endothelial-specific PHD2 knockout (PHD2ECKO) mouse fed with normal diet or high fat diet (HFD), liver lipid accumulation and fibrosis were measured by Oil Red O and Masson trichrome staining.

[Treatment of Pauwels type III femoral neck fractures with modified percutaneous compression plate].

Objective: To investigate the preliminary effects of modified percutaneous compression plate in treating femoral neck fractures of Pauwels type III.

Methods: From March 2012 to March 2016, 35 patients with femoral neck fracture were treated by closed reduction and internal fixation with a modified percutaneous compression plate, including 21 males and 14 females with an average age of 45 years old ranging from 23 to 62 years old. The anatomical position of fracture was divided into 8 cases of lower head type, 27 cases of head and neck.

Use of electroacupuncture and transcutaneous electrical acupoint stimulation in reproductive medicine: a group consensus.

With the rapid development of assisted reproductive technology, various reproductive disorders have been effectively addressed. Acupuncture-like therapies, including electroacupuncture (EA) and transcutaneous electrical acupoint stimulation (TEAS), become more popular world-wide. Increasing evidence has demonstrated that EA and TEAS are effective in treating gynecological disorders, especially infertility.

[Study on discourse right construction of China's medical aid to Africa].

Objective: To analyze the discourse right construction of China's medical aid to Africa, so as to provide evidences for improving the effect and sustainable development of China's medical aid to Africa.

Methods: The documents of the discourse right that China constructed in the medical aid to Africa were selected at different periods as discourse samples. The achievement and deficiency were analyzed from four aspects, namely confident, charismatic, influential, and dominant.

Effect of miRNA-27a and Leptin Polymorphisms on Risk of Recurrent Spontaneous Abortion.

BACKGROUND The aim of this study was to investigate the possible associations of miRNA-27a and Leptin polymorphisms with the risk of recurrent spontaneous abortion (RSA). MATERIAL AND METHODS Between May 2013 and April 2015 at Shenzhen Longhua New District Central Hospital, we randomly recruited 138 RSA patients as the case group and another 142 normal pregnancy women as the control group. We used denaturing high-performance liquid chromatography (DHPLC) to determine the genotypes and allele frequencies of miRNA-27a rs895819 A/G and Leptin rs7799039 G/A.

[Study on the change of semantic perspective of schistosomiasis control in China].

Objective: To analyze the evolution process, discourse and semantic meaning of schistosomiasis prevention and control, so as to provide suggestions for control work.

Methods: The official documents and mainstream media reports of schistosomiasis prevention and control were selected at different periods as discourse samples, and the deep social reasons behind the strategy change and the semantic meaning of the utterance were analyzed at different periods.

Results: The discourse of schistosomiasis prevention and control experienced the evolution of the political discourse, pluralistic discourse and public discourse, and the semantic connotations showed the authority conflict semantic features, and then transferred to semantic cooperation.

[Operative treatment for proximal humeral fracture with rotator cuff tear in elderly patients].

Objective: To explore operative clinical outcomes of proximal humeral fracture with rotator cuff tear in elderly patients.

Methods: From March 2010 to August 2014,54 elderly patients with proximal humeral fractures with rotator cuff tear were performed operation, including 30 males and 24 females aged from 68 to 83 years old with an average of 71.5 years old.