Publications by authors named "Li-ya Yuan"
Article Synopsis
- Arboviruses, specifically dengue virus serotype 2, can evolve rapidly through single nucleotide changes, leading to more severe outbreaks and replacement of existing virus strains.
- A study in Taiwan between 2001 and 2003 tracked the evolution from early epidemic strain (Ia) to later strains (Ib and II), which had key amino acid mutations that increased replication efficiency at lower temperatures.
- The findings reveal that a specific mutation in the NS5 protein boosts replication and virulence, enhancing our understanding of dengue outbreaks and helping predict future viral strains with greater epidemic potential.
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a major public health threat globally, especially during the beginning of the pandemic in 2020. Reverse transcription-quantitative PCR (RT-qPCR) is utilized for viral RNA detection as part of control measures to limit the spread of COVID-19. Collecting nasopharyngeal swabs for RT-qPCR is a routine diagnostic method for COVID-19 in clinical settings, but its large-scale implementation is hindered by a shortage of trained health professionals.
View Article and Find Full Text PDFIn our previous study, it was found that aspirin (ASA) exerted antimyeloma actions and . The resistance to bortezomib (BTZ) in multiple myeloma (MM) is partly due to AKT activation and the upregulation of survivin induced by BTZ, which are the targets of ASA in gastric and ovarian cancer, respectively. Thus, the present study investigated the interaction between ASA and BTZ in MM and further clarified the underlying mechanisms.
View Article and Find Full Text PDFObjectives: Aspirin (ASA) has been frequently used for thromboprophylaxis in patients with multiple myeloma (MM) when treated with thalidomide or lenalidomide. Despite the well-recognized chemopreventive role of ASA in some solid tumors particularly for colon cancer, whether ASA displays the antimyeloma activity remains unclear.
Methods: MM1.
[Incidence of JAK2V617F mutation in myeloproliferative diseases and its clinical significance].
Zhejiang Da Xue Xue Bao Yi Xue Ban
March 2010
Objective: To investigate the incidence of JAK2V617F gene point mutation in patients with myeloproliferatives diseases (MPD) and its clinical significance.
Methods: Genomic DNA from bone marrow and peripheral blood cells were extracted from 68 patients with MPD. Allele specific polymerase chain reaction was used to amplify the exon 12 of JAK2 gene which harbours V617F mutation.