Publications by authors named "Li-xiu He"
Clinical Subtypes of Neutrophilic Asthma: A Cluster Analysis From Australasian Severe Asthma Network.
J Allergy Clin Immunol Pract
March 2024
Background: Clinical heterogeneity may exist within asthma subtypes defined by inflammatory markers. However, the heterogeneity of neutrophilic asthma (NA) remains largely unexplored.
Objective: To explore potential clusters and the stability of NA.
Article Synopsis
- Some asthma patients who have a lot of neutrophils in their lungs don't respond well to a common treatment called glucocorticoids.
- Researchers found that a type of immune cell called ILC3s is more common in these patients and may help cause inflammation in their airways.
- The study shows that ILC3s resist glucocorticoids and release chemicals that call in more neutrophils, which makes asthma worse.
Human chorionic gonadotrophin (hCG), a glycohormone widely used in treatment of infertility, is a heterodimer composed of an alpha- and a beta-subunit. The heterodimer could be dissociated during production and storage with an impact on its bioactivity. A CE-SDS method for quantitative analysis of hCG subunit dissociation was established in this study by optimization of a variety of method conditions including sample preparation buffer compositions, incubation temperature, separation voltage, and capillary temperature.
View Article and Find Full Text PDFBackground: Airway structure changes, termed as airway remodeling, are common in asthma patients due to chronic inflammation, which can be assessed by high-resolution computed tomography (HRCT). Considering the controversial conclusions in the correlation of morphologic abnormalities with clinical feature and outcome, we aimed to further specify and evaluate the structural abnormalities of Chinese asthmatics by HRCT.
Methods: From August 2012 to February 2015, outpatients with asthma were recruited consecutively in the Asthma Center of West China Hospital, Sichuan University.