Publications by authors named "Li-xin Cai"

Objectives: Although hemispheric surgeries are among the most effective procedures for drug-resistant epilepsy (DRE) in the pediatric population, there is a large variability in seizure outcomes at the group level. A recently developed HOPS score provides individualized estimation of likelihood of seizure freedom to complement clinical judgement. The objective of this study was to develop a freely accessible online calculator that accurately predicts the probability of seizure freedom for any patient at 1-, 2-, and 5-years post-hemispherectomy.

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Plantation ecosystems are more vulnerable than natural ones to global climate change. Using the dendrochronology method, we established tree-ring width chronologies of distributed in the semi-arid region of Northeast China. We examined its growth dynamics, analyzed the relationship between radical growth and climate factors, and explored the effects of global warming on the growth and distribution of .

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Article Synopsis
  • The study aimed to compare two surgical techniques—vertical parasagittal and lateral peri-insular/peri-Sylvian hemispherotomy—specifically to see which is better for achieving long-term seizure freedom in patients.* -
  • Data from 672 participants indicated that 62.4% achieved seizure freedom over 10 years, with the vertical approach showing higher long-term success rates: 88.8% at 1 year, diminishing to 85.5% at 5 and 10 years, while the lateral approach saw a decline from 89.2% to 57.2% over the same periods.* -
  • The analysis revealed that the vertical technique had a significant advantage in maintaining seizure freedom over
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Article Synopsis
  • A study was conducted to create and validate a model that can predict seizure freedom in children undergoing hemispheric surgery for drug-resistant epilepsy, analyzing data from 1267 surgeries across 32 centers globally.
  • The results showed that 66% of patients achieved seizure freedom 3 months post-surgery, with a predictive model developed using factors like age at seizure onset and imaging results, achieving a moderately high predictive accuracy (area under the curve = .72).
  • The study introduced the Hemispheric Surgery Outcome Prediction Scale (HOPS), which helps identify children who will benefit from surgery and informs medical decisions, potentially avoiding unnecessary surgeries for those unlikely to gain seizure control.
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Pneumocephalus is a common finding after burr-hole drainage of chronic subdural hematoma (CSDH). Its effects have not been specifically studied. A retrospective analysis was performed in 140 patients with CSDH with single burr-hole drainage.

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Aims: To investigate clinical characteristics and surgery outcomes of young children with focal cortical dysplasia (FCD) type II.

Methods: Young children (onset age ≤6 years) with FCDII who underwent epileptic surgery in Children Epilepsy Center of Peking University First Hospital in 2014-2018 were followed up for at least 6 months after surgery.

Results: One hundred and twelve children with FCDII were included, with median age of onset 0.

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Objective: To investigate the clinical features and surgical strategy for pediatric intractable epilepsy due to posterior quadrantic cortical dysplasia and to assess the surgical outcomes.

Methods: The clinical features and preoperative evaluation results of 14 children with intractable epilepsy due to posterior quadrantic cortical dysplasia were retrospectively analyzed. The localization values of video-electroencephalography and intraoperative monitoring and the indications, advantages and disadvantages of temporoparietooccipital disconnection were evaluated.

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Neural stem cell (NSC) proliferation and differentiation play a pivotal role in the development of brain, the plasticity of the brain network, and the repair for brain function in CNS diseases. The mechanisms regulating NSC behavior are not well elucidated. Previous studies showed porf-2 functions as a modulator in central nerve system development.

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Background: Monohydroxycarbamazepine (MHD, 10-hydroxy-carbamazepine) is the main active metabolite of oxcarbazepine (OXC). The present study aims to investigate the relationship between plasma and saliva concentrations of MHD in Chinese children with epilepsy.

Methods: Plasma and saliva samples were collected and MHD levels were measured by high-performance liquid chromatography system.

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Subject: The objective of this study was to assess outcome with regard to seizure status and neurological function in patients undergoing resective surgery involving the perirolandic area.

Method: All 15 patients who underwent perirolandic cortical resection between October 2006 and September 2007 at the Comprehensive Epilepsy Centre of Beijing Xuanwu Hospital were included in the study. The locations of functional cortical areas, ictal onset zones and epileptogenic lesions were mapped by chronic intracranial EEG recordings and electric cortical stimulation.

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Objective: To discuss the correlation between characteristics of interictal epileptiform discharge (IED) and histopathological changes in epilepsy patients with focal cortical dysplasia (FCD) in order to explore the epileptogenicity of various IED.

Methods: Twenty-two consecutive patients suspected as with FCD who were to undergo epilepsy surgery received intracranial electrode implantation and long-term video-EEG monitoring before the resective surgery and the postoperative pathology proved the diagnosis of FCD. According the long-term EEG monitoring results, the IEDs were divided into four catalogs: isolated spike, slow repetitive spike, repetitive spike, and paroxysmal fast.

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Objective: To discuss the localizing methods for epileptogenic zone with intraoperative electrocorticography (ECoG) by comparing it with long-term intracranial EEG.

Methods: Twenty-two patients was enrolled, who received epilepsy surgeries consecutively in our institute since April 2005 to August 2006. All patients underwent intracranial electrode implantations with long-term video-EEG monitoring before the resective surgeries and the postoperative pathologies were all proved to be focal cortical dysplasia.

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Objective: To discuss the presurgical evaluation and surgical treatment of lesional temporal lobe epilepsy (LTLE).

Methods: We retrospectively studied the patients whose MRI or CT showed lesions on one of the temporal lobes among patients who underwent epilepsy surgeries in our institute. All patients were divided into satisfactory and unsatisfactory group according to outcomes after operation.

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