Publications by authors named "Li-xia Liang"
Article Synopsis
- - The study aims to analyze the diagnosis process of two patients with unique thalassemia genotypes, focusing on why some cases may be missed or misdiagnosed, to enhance detection methods for rare thalassemia types.
- - Researchers used family history, blood tests, and advanced DNA sequencing techniques to identify these uncommon genetic combinations, noting that both combinations were reported for the first time.
- - The findings contribute to a better understanding of genetic mutations in thalassemia among the Chinese population, offering valuable data for diagnosing and counseling on this condition.
Evidence from animal experiments has shown that chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) can induce vision dysfunction in zebrafish. However, environmental epidemiological evidence supporting this hypothesis remains limited. In our case-control study, samples collected from 270 individuals (135 controls and 135 cases) from the Isomers of C8 Health Project data were analyzed for Cl-PFESAs.
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- - The study analyzed data from 1,238 adults to evaluate how different types of PFAS (per- and polyfluoroalkyl substances) affect red blood cell indices, focusing on both isomer and sex differences.
- - Results indicated that linear (n-) isomers of PFAS showed a stronger positive impact on red blood cell indices in women compared to men, with significant changes in hemoglobin and red blood cell counts.
- - Findings suggest that when assessing health risks of PFAS, it’s important to consider the specific chemical structures, demographic factors like sex, and their combined effects.
Chlorinated polyfluorinated ether sulfonate, commercially known as F-53B, has been associated with adverse birth outcomes. However, the reproductive toxicology of F-53B on the placenta remains poorly understood. To address this gap, we examined the impact of F-53B on placental injury and its underlying molecular mechanisms in vivo.
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- F-53B is a chemical that can harm the liver and intestines, and it's being studied to understand how it does this.
- In an experiment, mice were exposed to different amounts of F-53B for 28 days, and researchers found it built up in the liver and intestines.
- The study showed that F-53B caused damage to the gut and liver, changed the bacteria in the gut, and linked these changes to inflammation and fat processing in the body.
Numerous studies have suggested per-and polyfluoroalkyl substances (PFASs) are related to uric acid levels, but evidence related to PFAS alternatives is limited. Moreover, the effect of the combined exposure to PFASs and their alternatives on uric acid has not been reported. Hence, we conducted a cross-sectional study involving 1312 adults in Guangzhou, China.
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- This study investigates the neurotoxic effects of F-53B on children and mice, linking higher levels of F-53B to poorer cognitive performance in the Wisconsin Card Sorting Test (WCST).
- Experimental findings indicated that mice exposed to F-53B showed impaired learning and decreased levels of key proteins and dopamine related to brain development and function.
- The results suggest early life exposure to F-53B may negatively impact neurodevelopment, warranting further research on its health implications.
Objective: To investigate the effects of chromosome polymorphism on the clinical outcomes of fertilization/embryo transfer (IVF/ET)-assisted reproductive technology.
Methods: The case data of 2740 patients treated between January 2018 and January 2019 were retrospectively analyzed. The patients were organized into two groups: a case group and a control group.
Article Synopsis
- Maternal exposure to chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) is linked to neurobehavioral issues in the offspring of zebrafish, as shown in this study.
- The study found that higher concentrations of Cl-PFESAs in zebrafish embryos resulted in decreased swimming speed and distance traveled in the larvae.
- Additionally, Cl-PFESAs were found to disrupt calcium homeostasis, cause dopaminergic dysfunction, and lead to eye developmental defects, all contributing to behavioral changes in the offspring.
Article Synopsis
- A study in Guangzhou, China investigated the impact of per- and polyfluoroalkyl substances (PFASs) exposure on heart function using ECG parameters among 1,229 adults with an average age of 55.1 years.* -
- Researchers analyzed 13 PFASs and focused on six ECG parameters, finding that exposure to higher levels of PFASs was linked to a decrease in heart rate (HR) and QRS duration, while the PR interval increased.* -
- For instance, at high exposure levels of 6:2 Cl-PFESA, HR decreased by nearly 7 beats per minute and QRS duration decreased by about 6 milliseconds, while the PR interval increased by over
Background: Previous studies have indicated that chlorinated polyfluorinated ether sulfonic acids (Cl-PFESAs), when used as an alternative to per- and polyfluoroalkyl substances (PFASs), result in kidney toxicity. However, their co-exposure with heavy metals, has not yet been described.
Objectives: To explore the joint effects of Cl-PFESAs and heavy metal exposure on renal health in Chinese adults, and identify specific pollutants driving the associations.
Article Synopsis
- The study investigates the relationship between long-term exposure to ultra-fine particles (UFPs) and obesity in children in Northeastern China, highlighting a gap in previous research on air pollution's impact on childhood obesity.
- The researchers analyzed data from nearly 48,000 children aged 6-18 and found that higher UFP exposure correlated with increased BMI Z-scores and obesity prevalence, especially among boys and those living near busy roads.
- The findings suggest that reducing UFP exposure could be important for addressing childhood obesity, emphasizing the need for more comprehensive air quality monitoring.
Experimental evidence has shown that per- and polyfluoroalkyl substances (PFAS) alternatives and mixtures may exert hepatotoxic effects in animals. However, epidemiological evidence is limited. This research aimed to explore associations of PFAS and the alternatives with liver function in a general adult population.
View Article and Find Full Text PDFIt has been reported that exposure to perfluorooctane sulfonates (PFOS) causes behavioral abnormalities in zebrafish larvae, but the possible mechanisms underlying these changes remain unexplored. In this study, zebrafish embryos (2 h postfertilization, 2-hpf) were exposed to PFOS at different concentrations (0, 0.032, 0.
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- The study aimed to explore how family care and coping strategies relate to the subjective well-being (SWB) of patients with coronary heart disease (CHD) after undergoing a medical procedure called percutaneous coronary intervention (PCI).
- Data was collected from 264 CHD patients through questionnaires that measured demographic information, coping methods, and their overall well-being, with analyses performed using statistical software.
- Findings showed that family care positively affects SWB, particularly more so in men, and that coping strategies mediate this relationship, suggesting that enhancing family support and coping techniques can lead to better well-being for patients post-PCI.
[Clinic analysis of 16 patients of craniocerebral trauma with Labbé vein injury].
Zhonghua Wai Ke Za Zhi
November 2011
Objectives: To study the mechanism of Labbé vein injury, and its effect on traumatic cerebral infarction and prognosis in patients of craniocerebral trauma.
Methods: The clinic imageology and data of 16 patients of craniocerebral trauma with Labbé vein injury approved intraoperatively from June 2006 to February 2009 were analyzed. To compare the effect of the intraoperative finding of Labbé vein damage and blood vessel treatment on traumatic cerebral infarction, and to analyze the traumatic cerebral infarction size and prognosis.
[Therapeutic effects of bone marrow transplantation on ovarian injury in mice].
Nan Fang Yi Ke Da Xue Xue Bao
September 2011
Objective: To evaluate the therapeutic effects of bone marrow transplantation (BMT) on ovarian injury induced by chemotherapy in mice.
Methods: Forty-eight mice were randomized equally into normal control group (A), cyclophosphamide and BMT group (B), and cyclophosphamide group (C). The mice in groups B and C were treated with intraperitoneal injection of cyclophosphamide at the daily dose of 150 mg/kg for 3 consecutive days, and allogeneic bone marrow cell transplantation was performed in group B.