Publications by authors named "Li-wen Zhang"
Oral squamous-cell carcinoma (OSCC) poses significant treatment challenges due to its high recurrence rates and the limitations of current therapies. Titanium dioxide (TiO) nanoparticles are promising radiosensitizers, while bacterial outer membrane vesicles (OMVs) are known for their immunomodulatory properties. This study investigates the potential of OMV-encapsulated TiO nanoparticles (TiO@OMV) to combine these effects for improved OSCC treatment.
View Article and Find Full Text PDFThe therapeutic potential of PX-478 in a murine model of pelvic organ prolapse.
J Obstet Gynaecol
December 2024
Background: Pelvic organ prolapse (POP), characterised by the downward displacement of pelvic organs, is a prevalent disorder that affects adult women. This study explored the therapeutic potential of PX-478, a selective hypoxia-inducible factor-1α (HIF-1α) inhibitor, in a murine POP model.
Methods: A murine POP model was established through ovariectomy, mimicking oestrogen deprivation.
Article Synopsis
- Vitamin E is an essential micronutrient that may reduce cardiovascular risk in diabetes patients with the Hp 2-2 genotype, though the exact mechanism is not well understood.
- A systematic review was conducted, examining 163 publications and ultimately including five studies with 463 participants, focusing on the effects of vitamin E on high-density lipoprotein (HDL) levels and function.
- Results showed that while vitamin E did not significantly change HDL levels across all Hp genotypes, it appeared to enhance HDL function, specifically improving cholesterol efflux in Hp 2-2 diabetes patients, indicating a potential pharmacogenetic interaction.
Article Synopsis
- - The new mechanochromic light control technology aims to create energy-saving windows that adjust to solar irradiation but faces challenges in selective modulation for various scenarios.
- - A layer-by-layer assembly method is introduced to produce a film that responds mechanically, allowing for dynamic modulation of visible and near-infrared light, with optical modulation rates of up to 42.4% at 550 nm.
- - The multilayer structure enhances both the film's optical performance and its durability, surviving up to 100,000 stretching cycles, and demonstrates a cooling effect in real-world applications, potentially benefiting energy-efficient design.
Background: The efficacy of bioresorbable vascular scaffolds (BVS) compared to metallic stents for the treatment of coronary heart disease remains controversial. The analysis of clinical outcomes at five years following the initial treatment has yet to be reviewed. This study sought to assess the five-year outcomes in randomized controlled trials of BVS in the treatment of coronary heart disease using a systematic review and meta-analysis.
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- Diffuse hyperpigmentation with guttate hypopigmentation (DHGH) is a newly identified skin disorder, primarily reported in Chinese females ages 6 to 24, characterized by hypopigmented spots on areas of diffuse hyperpigmentation.
- A detailed study analyzed nine cases, revealing distinct clinical, dermoscopic, and histopathological features, including blurred pigmented patches and abnormal epidermal pigment.
- DHGH is poorly understood, with unclear causes and mechanisms, suggesting that it might be more common than previously thought and requiring further research for better recognition and treatment.
Among the three most prevalent cancers affecting the female reproductive system, ovarian cancer (OV) ranks as the second most frequently diagnosed. It is important to investigate the genomic complexity of OV to develop diagnostic and therapeutic strategies. Through the utilization of bioinformatics analysis, it was determined that RacGTPase Activating Protein 1 (RACGAP1) holds significant significance in the field of OV chemotherapeutics, an aspect that has not been thoroughly explored in prior investigations.
View Article and Find Full Text PDFBackground And Objectives: Enhanced recovery after surgery (ERAS) recommends avoiding enteral nutrition (EN) due to undesirable sequelae such as pulmonary aspiration and infections. Not using of EN in nongastric resections under ERAS pathways is often successful. However, parenteral nutrition (PN) alone followed by early postoperative oral feeding in gastric cancer patients, recommended by the ERAS guidelines, has unclear benefit and is only adopted after gastric resection.
View Article and Find Full Text PDFObjective: The aim of this study was to evaluate the feasibility and necessity of enhanced recovery after surgery in elderly patients with colorectal cancer by observing inflammatory markers and postoperative complications.
Methods: Hospitalized colorectal cancer patients from the Affiliated Hospital of Jiangsu University from January 2021 to September 2022 were included in the study and divided into two groups: Enhanced Recovery After Surgery (ERAS) and non-ERAS. Data on postoperative inflammatory markers and complications were also collected.
Background: Ovarian cancer is an extremely deadly gynecological malignancy, with a 5-year survival rate below 30%. Among the different histological subtypes, serous ovarian cancer (SOC) is the most common. Anoikis significantly contributes to the progression of ovarian cancer.
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