Golden bifid might improve diarrhea-predominant irritable bowel syndrome via microbiota modulation.

Objective: Gut microbiota might play a crucial role in the pathogenesis of irritable bowel syndrome (IBS), and probiotics supplement may be an effective treatment option. This study aims to explore the therapeutic effects of Golden bifid on the diarrhea-predominant IBS (IBS-D).

Methods: Twenty-one consecutive IBS-D patients were recruited based on Rome IV criteria.

Natural history of adult-onset Ménétrier's disease: Report of a case with 9-year follow-up.

Ménétrier's disease (MD) is a rare disease characterized by markedly hypertrophied gastric mucosal folds typically associated with hypoalbuminemia and anemia. However, the natural history of MD in adults remains unclear and is rarely reported in the literature. The current study presents a case of MD with a 9-year follow-up.

The spectra, symptom profiles and overlap of Rome III functional gastrointestinal disorders in a tertiary center in South China.

Objective: Most previous studies exploring the overlap of functional gastrointestinal disorders (FGID) focus on the overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS). In this study, we aimed to explore the spectra, symptom profiles and overlap of all FGID using the validated Chinese version of the Rome III questionnaire.

Methods: Consecutive newly diagnosed FGID patients who were admitted to the Outpatient Gastroenterology Clinic from 10 May to 10 September 2012 were recruited in the study.

Improved biopsy accuracy in Barrett's esophagus with a transparent cap.

Aim: To evaluate the efficacy of endoscopy with a transparent cap on biopsy positioning in Barrett's esophagus (BE).

Methods: One hundred and sixty-eight patients with suspected BE at endoscopy were enrolled in our study from November 2007 to December 2009 and divided into two groups: transparent cap group (n = 60) and control group (n = 108). Endoscopy with or without a transparent cap and subsequent biopsy of suspected lesions were performed by five experienced endoscopists in our hospital.

Prevalence, clinical manifestations and endoscopic features of eosinophilic esophagitis: a pathological review in China.

Objective: We aimed to determine the prevalence of eosinophilic esophagitis (EoE) and define its clinical and endoscopic characteristics in Chinese patients.

Methods: Esophageal specimens obtained from January 2006 to December 2010 in the First Affiliated Hospital of Sun Yat-sen University were reviewed, and the data on clinical characteristics and endoscopic findings of patients were obtained. Patients with eosinophils ≥15 per high power field (HPF) were identified as having EoE.

[A population-based epidemiologic study of bowel habits in Guangdong province].

Objective: To determine the bowel habits and its perceptions in the general population of Guangdong province.

Methods: Random clustered sampling involving permanent inhabitants aged 18 - 80 year was carried out under stratification of urban and suburban areas in Guangdong province. Questionnaire included the items on the characteristics of people being selected and their bowel habits.

Relationship between symptom response and esophageal pH level on standard dose of esomeprazole treatment for gastroesophageal reflux disease.

Background: The relationship between symptom elimination and normalization of esophageal acid level of gastroesophageal reflux disease (GERD) on proton-pump inhibitor (PPI) therapy has been questioned. This study aimed to evaluate the relationship between symptom response and gastro-esophageal acidity control in Chinese patients with GERD on esomeprazole therapy, and to assess the role of 24-hour esophageal pH-metry after therapy in GERD patients.

Methods: GERD patients with typical reflux symptoms were enrolled and received esomeprazole 40 mg once daily for 4 weeks.

Prevalence and risk factors of Barrett's esophagus in patients undergoing endoscopy for upper gastrointestinal symptoms.

Objective: To investigate the prevalence of Barrett's esophagus (BE) and its risk factors in patients undergoing endoscopy for upper gastrointestinal symptoms in a Chinese tertiary referral medical center.

Methods: All consecutive patients receiving an endoscopy for upper gastrointestinal symptoms in our medical center from September to December 2007 were recruited. BE was explored for at endoscopy when a suspected columnar-lined esophagus was found.

Prompt upper endoscopy is an appropriate initial management in uninvestigated chinese patients with typical reflux symptoms.

Objectives: We sought to investigate the prevalence of clinically significant endoscopic findings (CSEFs) in Chinese patients presenting with uninvestigated typical reflux symptoms in the absence of alarm symptoms, and to evaluate whether prompt endoscopy is an appropriate initial management in these patients.

Methods: Consecutive patients presenting with uninvestigated typical reflux symptoms (i.e.

[Side effects of non-steroidal anti-inflammatory drugs on gastric mucosa and preventive effects of teprenone].

Objective: To evaluate the side effects of non-steroidal anti-inflammatory drugs (NSAID) on gastric mucosa, and to study the preventive effects of teprenone in patients.

Methods: 108 patients taking NSAID for more than 3 months with no infection of helicobacter pylori (Hp) were collected. All patients were screened by endoscopy and their upper gastrointestinal symptoms were evaluated.

The clinical overlap between functional dyspepsia and irritable bowel syndrome based on Rome III criteria.

Background: Epidemiological studies suggest considerable overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS). To date, no surveys have been performed to investigate the clinical overlap between these two disorders using Rome III criteria. Our aim was to investigate the prevalence and risk factors for the overlap of FD and IBS based on Rome III criteria in a large clinical sample.

[A comparison between Rome III and Rome II criteria in diagnosing irritable bowel syndrome].

Objective: To determine the degree of agreement of Rome III and Rome II criteria in diagnosing irritable bowel syndrome (IBS) and to compare the clinical difference between the patients diagnosed with these two criteria.

Methods: 3014 patients in the gastrointestinal outpatient department were enrolled consecutively and interviewed face to face with a standard questionnaire.

Results: (1) 480 patients were diagnosed as IBS with Rome III criteria.

Stratification and symptom characteristics of non-erosive reflux disease based on acid and duodenogastroesophageal reflux.

Background And Aim: The subgroups and symptom characteristics of non-erosive reflux disease (NERD) based on acid and duodenogastroesophageal reflux may be different in Chinese patients to Western patients. This study aimed to explore the stratification and symptom characteristics of patients with NERD.

Methods: Patients with typical heartburn and/or acid regurgitation symptoms were enrolled.

[Epidemiology investigation of colorectal cancer on community group in Guangdong province].

Objective: To explore the epidemiology characteristics of colorectal cancer on community group in Guangdong province.

Methods: Huidong was took as the research spot to investigate the sickness and incidence of colorectal cancer among a whole community group in Guangdong province, and two projects were used simultaneously: "screening of colorectal cancer in high risk group" and "screening project using fecal occult blood test". The numeration time for population of 10 towns was set at July 1, 2005.

[Changes of intercellular spaces of esophageal epithelium in patients with gastroesophageal reflux disease before and after esomeprazole treatment].

Objective: To observe the changes of dilated intercellular space (DIS) of esophageal epithelium in different subtypes of gastroesophageal reflux disease (GERD) before and after esomeprazole treatment.

Methods: Nineteen patients with GERD, 6 with erosive esophagitis (EE), 7 with NERD with abnormal acid exposure (NERD pH+), and 6 with NERD with normal acid exposure (NERD pH-), were treated with esomeprazole 40 mg daily for two months. During endoscopy before and after treatment, six biopsy specimens were taken from the apparently normal mucosa 3 - 5 cm above the dentate line in the esophagus to undergo HE staining and histological examination and transmission electron microscopy (TEM).

[The risk factors and impact of gastroesophageal reflux disease on quality of life in general population].

Objectives: To assess the risk factors of gastroesophageal reflux disease (GERD) in the general population and its impact on health-related quality of life (HRQOL).

Methods: A face-to-face interview was carried out in Guangdong Province using a validated Chinese version Reflux Disease Questionnaire (RDQ) to assess the prevalence of GERD. Random clustered sampling of permanent inhabitants aged 18 to 90 years was carried out under stratification of urban and suburban areas.

[Evaluation of the quality of life of patients with irritable bowel syndrome].

Objective: To explore and assess the health-related quality of life (HRQOL) of irritable bowel syndrome (IBS) patients in the population.

Methods: Random clustered sampling involving permanent inhabitants aged 18 - 80 yr was carried out under stratification of urban and suburban areas in Guangdong Province. Altogether 231 IBS patients fulfilling the Rome II criteria and 636 Non-IBS as control were collected.

[A population-based epidemiologic study of irritable bowel syndrome in Guangdong province].

Objective: To explore the prevalence of irritable bowel syndrome (IBS) and its risk factors in Guangdong province.

Methods: A questionnaire was used to screen IBS by face-to-face interviews according to Manning (modified including symptoms of constipation) and Rome II criteria. Random clustered sampling involving permanent inhabitants aged 18 - 80 years was carried out under stratification of urban and suburban areas.