Gd-EOB-DTPA-enhanced MR findings in chemotherapy-induced sinusoidal obstruction syndrome in colorectal liver metastases.

Background: We assessed the clinical presentations, biomarkers, and Gd-EOB-DTPA-enhanced MRI features that were associated with oxaliplatin-induced sinusoidal obstruction syndrome (SOS) to detect chemotherapy-associated SOS in a timely manner.

Methods: Fifty-seven patients who underwent oxaliplatin-based chemotherapy and Gd-EOB-DTPA-enhanced MRI were included. Post-oxaliplatin heterogeneity in liver parenchyma was scored on a grading scale of 0 to 3.

Comparison of gadoxetic acid versus gadopentetate dimeglumine for the detection of hepatocellular carcinoma at 1.5 T using the liver imaging reporting and data system (LI-RADS v.2017).

Purpose: The goal of this study was to investigate the Liver Imaging Reporting and Data System (LI-RADS) v.2017 for the categorization of hepatocellular carcinomas (HCCs) with gadoxetic acid compared with gadopentetate dimeglumine-enhanced 1.5-T magnetic resonance imaging (MRI).

Usefulness of two-point Dixon fat-water separation technique in gadoxetic acid-enhanced liver magnetic resonance imaging.

Aim: To compare differences between volumetric interpolated breath-hold examination (VIBE) using two-point Dixon fat-water separation (Dixon-VIBE) and chemically selective fat saturation (FS-VIBE) with magnetic resonance imaging examination.

Methods: Forty-nine patients were included, who were scanned with two VIBE sequences (Dixon-VIBE and FS-VIBE) in hepatobiliary phase after gadoxetic acid administration. Subjective evaluations including sharpness of tumor, sharpness of vessels, strength and homogeneity of fat suppression, and artifacts that were scored using a 4-point scale.

Simultaneous determination of sex hormones in egg products by ZnCl2 depositing lipid, solid-phase extraction and ultra performance liquid chromatography/electrospray ionization tandem mass spectrometry.

A method was developed for simultaneous determination of residues of 17 sex hormones in egg products. Target compounds were extracted from samples with methanol in an ultrasonic bath, effectively separated from lipids in the extracts by ZnCl(2) depositing filtration and purified using a C(18) solid-phase extraction (SPE) and followed by NH(2) SPE cartridge. The analytes were quantified by liquid chromatography using a BEH C(18) column coupled to an electrospray ionization tandem mass spectrometer (LC-ESI-MS/MS) operating in negative mode for estrogens and in positive multiple reaction monitoring mode for androgens.

Titanium-coated silica spheres prepared by self-assembly technique for use as HPLC packing.

Titania-coated silica spheres were prepared by a layer-by-layer self-assembly technique for use as a high-performance liquid chromatography packing. This packing has a high surface area of 202.1 m(2)/g, a large pore volume of 0.

[Comparative study on clinical and pathological changes of liver fibrosis with diffusion-weighted imaging].

Objective: To evaluate the clinical practical value of apparent diffusion coefficient (ADC) measurements based on diffusion-weighted MR imaging (DWI) for quantification of liver fibrosis and inflammation for hepatitis viral infection.

Methods: Diffusion-weighted MRI with parallel imaging was prospectively performed on 85 patients with chronic hepatitis and on 22 healthy volunteers within a single breath-hold using a single-shot spin-echo echo-planar sequence at b values of 100, 300, 500, 800 and 1000 s/mm2 respectively. ADC values of liver were measured with five different b values.

[The value of breath-hold diffusion-weighted imaging in small hepatocellular carcinoma lesion (

Objective: To evaluate the added value of single breath-hold diffusion-weighted imaging (DWI) in detection of small HCC lesions (
Methods: A total of 54 patients with chronic liver diseases underwent abdominal MRI at 1.5 T, including T1-weighted (T1WI), T2-weighted (T2WI), and 2D conventional DCE.

Preparation and evaluation of non-bonded hyperbranched polymer-coated columns for capillary electrophoresis.

A series of hyperbranched poly(amine-ester)s based on 1,1,1-trimethylolpropane, methyl acrylate and diethanolamine were synthesized and coated on the inner surface of the fused-silica capillaries by physical adsorption. The most effective coating was the seventh generation hyperbranched poly(amine-ester) coating, which reduced the electroosmotic flow (EOF) greatly and suppressed protein adsorption effectively. The high separation efficiencies for basic proteins were obtained and the coating had a good stability.

[Comparison of MRI manifestations and histopathologic findings in pancreatic head carcinoma in vivo ex vivo].

Objective: To prospectively analyze the correlation of MRI image characteristics with histopathological findings in pancreatic head carcinoma in vivo and ex vivo.

Methods: Sixteen patients with pancreatic head carcinoma were examined by 1.5T MRI.

[MRI in the evaluation of peripancreatic vessel invasion and resectability of pancreatic carcinoma].

Objective: To investigate the role of MRI in evaluating the peripancreatic vessel invasion and resectability of pancreatic carcinoma based on the comparison of MRI image with surgical exploration, and try to establish the criteria for assessment of the sensitivity, specificity and accuracy of resectability.

Methods: Forty-one pancreatic carcinoma patients confirmed by pathology received preoperative plain and contrast enhanced MRI scan, and 37 of them had additional coronal MRA scan. Peripancreatic vessel invasion was preoperatively assessed based on MRI features, and the vessel invasion degree from the uninvolved to the severely involved was divided into 6 grades represented by 1, 2a, 2b, 3a, 3b and 4, respectively.

Assessment of T staging and mesorectal fascia status using high-resolution MRI in rectal cancer with rectal distention.

Aim: To determine the accuracy of high-resolution magnetic resonance imaging (MRI) using phased-array coil for preoperative assessment of T staging and mesorectal fascia infiltration in rectal cancer with rectal distention.

Methods: In a prospective study of 67 patients with primary rectal cancer, high-resolution magnetic resonance imaging (in-plane resolution, 0.66 multiply 0.

[Evaluation of 2D and 3D MRI imaging in the diagnosis of pancreatic carcinoma].

Objective: To evaluate various kinds of sequences and modified dynamic contrast-enhanced MRI methods in the diagnosis of pancreatic carcinoma.

Methods: Forty-nine pancreatic carcinoma patients proved by histopathology or clinical examination and follow-up underwent MR examination. Plain MR sequences included: T1-weighted 2D FLASH, T1 WI 3D VIBE, TSE T2 WI and HASTE with FS.

The value of diffusion-weighted imaging in combination with T2-weighted imaging for rectal cancer detection.

Objective: To evaluate the clinical value of diffusion-weighted imaging (DWI) in combination with T(2)-weighted imaging (T(2)WI) for the detection of rectal cancer as compared with T(2)WI alone.

Materials And Methods: Forty-five patients with rectal cancer and 20 without rectal cancer underwent DWI with parallel imaging and T(2)WI on a 1.5 T scanner.

[HPLC fingerprinting of total glycosides of Swertia franchetiana].

Aim: To establish a sensitive and specific HPLC method for controlling the quality of total glycosides from Swertia franchetiana H. Smith.

Methods: HPLC method was applied for quality and quantitative assessment of the pharmaceutical extracts from Swertia franchetiana H.

Normal-phase HPLC enantioseparation of novel chiral metal tetrahedrane-type clusters on an amylose-based chiral stationary phase.

In the present work, an amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral stationary phase (CSP) was prepared by coating ADMPC on small-particle silica gel. This ADMPC-CSP was for the first time successfully applied to separate a series of novel chiral metal tetrahedrane-type clusters. Furthermore, the influence of a mobile-phase modifier (various alcohols added in the mobile phase), including its concentration and structure, and the structures of the clusters on the chiral separation and retention was investigated.

Separation of cefoperazone enantiomers using beta-cyclodextrin as chiral additive by capillary zone electrophoresis.

A capillary electrophoresis method was developed to separate the enantiomers of cefoperazone. Different cyclodextrins, including alpha-cyclodextrin (alpha-CD), beta-cyclodextrin (beta-CD), gamma-cyclodextrin (gamma-CD), 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD), and methyl-beta-cyclodextrin (Me-beta-CD), were tested as chiral additives in the running buffer. The effect of various parameters on enantioseparation such as concentration of NaH(2)PO(4), buffer pH, and CD concentration was also studied.

Enhancement patterns of small hepatocellular carcinoma shown by dynamic MRI and CT.

Objectives: To study prospectively the enhancement features of small hepatocellular carcinoma (SHCC) with multi-phase scanning of dynamic MRI and spiral CT, and discuss the superiority of dynamic MRI to spiral CT.

Methods: Multi-phase dynamic contrast scanning of high field MRI and spiral CT were performed in 53 patients with SHCC. The arterial phase, portal venous phase and delayed phase scanning of spiral CT was done after the pre-contrast scanning of the entire liver.

[Studies of aroma components on essential oil of Chinese kushui rose].

The main chemical components of the rich peculiar aroma in the essential oil of Chinese Kushui rose (R. Setate x R. Rugosa) is reported.

[Determination of alkaloids from Coptis chinensis Franch. and Phellodendron amurense Rupr. Decocted together in baitouweng decocta by high performance capillary electrophoresis].

A rapid and accurate method for determining alkaloids from Coptis chinensis Franch, and Phellodendron amurense Rupr, decocted together in Baitouweng decocta was established. Experiments were carried out on a self-assembled capillary electrophoresis system. The experimental conditions were as follows: 75 microns i.

Determination of serum thyroxine enantiomers in patients by liquid chromatography with a chiral mobile phase.

A chromatographic method for the separation and determination of D- and L-thyroxine enantiomers (D-, and L-T4) in human serum with a chiral ligand ion-exchange system using a chiral mobile phase additive and a silica column was established. An aqueous eluent containing L-proline (L-pro) sufficiently complexed copper II ions and triethylamine (TEA) was used. It was monitored with a UV detector.

[Influence of mobile phase composition on chiral separation of organic selenium racemates].

The chiral separation of some chiral compounds with similar structure on the cellulose tris (3,5-dimethylphenylcarbamate) chiral stationary phase prepared by us was obtained. Ternary mobile phases influencing chiral recognition were investigated. A mode of interaction between the structural character of samples and chiral stationary phase is discussed.

[Effect of the bonding amounts of chiral ligand exchange chromatographic stationary phases on the enantioseparation of amino acids].

L-proline chiral stationary phases with various bonding amounts for ligand exchange chromatography were prepared by treating silica gel with 3-glycidoxypropyltrimethoxysilane and bonding L-proline. The bonding amounts of L-proline chiral stationary phase were controlled effectively and characterized by IR and elemental analysis. Some DL-amino acids were separated and the influences of the bonding amounts on the efficiency of resolution of DL-amino acids by ligand exchange chromatography were briefly discussed and explained by the mechanism of the separation.