An electrogenerated chemiluminescence aptasensor for lysozyme based on the interaction between Ru(bpy) and cucurbit[8]uril.

Strong anodic Ru(bpy) electrogenerated chemiluminescence (ECL) was obtained at a cucurbil[8]uril (CB[8]) modified electrode in neutral conditions without the need of an additional coreactant. An ECL aptasensor was fabricated based on the strong ECL emission as well as the host-guest interaction between DNA and CB[8]. Firstly, amino group-terminated complementary DNA (DNA-NH ) was firmly immobilized on CB[8]/glass carbon electrode, which could further increase ECL intensity.

Research progresses on the molecular structure of the Hippo signaling pathway components.

The Hippo signaling pathway has been identified to be involved in development and tissue homeostasis during the past decade, and is evolutionarily conserved from Drosophila to mammals. It transduces the signal through a series of protein-protein interaction and kinase cascades, to control the cell number and organ size by inhibiting cell proliferation and promoting apoptosis. Dysregulation of the Hippo signaling pathway is associated with tumorigenesis and cancers, so it is a crucial target for cancer therapy and regeneration medicine.