Ethylene-induced NbMYB4L is involved in resistance against tobacco mosaic virus in Nicotiana benthamiana.

Several MYB transcription factors are known to play important roles in plant resistance to environmental stressors. However, the mechanism governing the involvement of MYBs in regulating tobacco mosaic virus (TMV) resistance in plants is still unclear. In this study, we found that not only is Nicotiana benthamiana MYB4-like involved in defence against TMV, but also that the ethylene pathway participates in MYB4L-mediated resistance.

Novel Compound Heterozygous Pathogenic Mutations of in a Chinese Patient With Congenital Hypothyroidism.

Background And Objectives: Defects in the human sodium/iodide symporter () gene have been reported to be one of the causes of congenital hypothyroidism (CH). We aimed to identify mutations in Chinese patients with CH and to evaluate the function of the mutation.

Methods: Two hundred and seventy-three patients with primary CH were screened for mutations in using next-generation sequencing.

Relationship between vascular endothelial growth factor -2578C > a gene polymorphism and lung cancer risk: a meta-analysis.

Background: Several reports were published on the relationship between the vascular endothelial growth factor (VEGF) -2578C > A gene polymorphism and lung cancer risk; however, the results are debatable. This meta-analysis was conducted to assess the relationship between VEGF -2578C > A gene polymorphism and lung cancer risk.

Methods: The associated literatures were identified on the 1st of September 2018 from CBM-disc (China Biological Medicine Database) and PubMed.

[Sensing of Cu²⁺ Based on Fenton Reaction and Unmodified Gold Nanoparticles].

Heavy metal pollution has received great attentions in recent years. The traditional methods for heavy metal detection rely on the expensive laboratory instruments and need time-consuming preparation steps; therefore, it is urgent to develop quick and highly sensitive new technologies for heavy metal detection. The colorimetric method based on the gold nanoparticles (AuNPs) features with simple operation, high sensitivity and low cost, therefore, enabling it widely concerned and used in the environmental monitoring, food safety and chemical and biological sensing fields.

RETRACTED: Relationship Between Aldosterone Synthase CYP1A1 MspI Gene Polymorphism and Prostate Cancer Risk.

Objective:: This study was conducted to assess the relationship between aldosterone synthase CYP1A1 MspI gene polymorphism and prostate cancer risk using meta-analysis.

Methods:: The search was conducted in PubMed and China Biological Medicine Database disc on October 1, 2015, and eligible reports were recruited and synthesized using meta-analysis method.

Results:: The eligible reports were recruited into this meta-analysis for the association of CYP1A1 MspI gene polymorphism with prostate cancer risk.

Association of glutathione S-transferase P1 gene polymorphism with the risk of small-cell carcinoma of lung cancer.

The conclusions of the published reports on the relationship between glutathione S-transferase P1 (GSTP1) gene polymorphism and the risk of small-cell carcinoma of lung cancer are still debated. GSTP1 is one of the important mutant sites reported at present. This meta-analysis was performed to evaluate the association between GSTP1 and the risk of small-cell carcinoma of lung cancer.

Association of vitamin D receptor gene polymorphism with the risk of renal cell carcinoma: a meta-analysis.

Relationship between vitamin D receptor (VDR) gene polymorphism and the risk of renal cell carcinoma from the published reports are still conflicting. This study was conducted to evaluate the relationship between VDR ApaI (rs7975232), BsmI (rs1544410), TaqI (rs731236), and Fok1 (rs2228570) gene polymorphism and the risk of renal cell carcinoma using meta-analysis method. The association studies were identified from PubMed, and Cochrane Library on 1 March 2014, and eligible investigations were included and synthesized using meta-analysis method.

Association of vitamin D receptor BsmI gene polymorphism with the risk of type 2 diabetes mellitus.

Relationship between vitamin D receptor (VDR) BsmI (rs1544410) gene polymorphism and the type 2 diabetes mellitus (T2DM) susceptibility is still conflicting at present. This meta-analysis was conducted to assess the association between VDR BsmI gene polymorphism and the risk of T2DM. The association studies were identified from PubMed, and Cochrane Library on 1 January 2014, and eligible investigations were included and synthesized using meta-analysis method.

Gold nanorod-covered kanamycin-loaded hollow SiO2 (HSKAu(rod)) nanocapsules for drug delivery and photothermal therapy on bacteria.

A hybrid bactericidal material, gold nanorod-covered kanamycin-loaded hollow SiO(2) (HSKAu(rod)) nanocapsules, is constructed. The hybrid material combines the features of a chemical drug with photothermal physical sterilization which decreases the dosage of broad-spectrum antibiotic and the physical damage of biological systems. Hollow SiO(2) nanocapsules are used as carriers for drug delivery.

Fenton's reagent-tuned DNA-templated fluorescent silver nanoclusters as a versatile fluorescence probe and logic device.

A label-free strategy based on the Fenton reaction with DNA-templated silver nanoclusters (DNA-Ag NCs) as a probe is demonstrated for the sequential detection of Cu(2+), ascorbic acid (AA) and H(2)O(2). Cu(2+) causes a structural change of the DNA template in DNA-Ag NCs to resist the environmental quenching and emit stronger fluorescence. The addition of AA in the presence of Cu(2+) results in a further fluorescence increase of the DNA-Ag NCs.

Label-free colorimetric sensing of ascorbic acid based on Fenton reaction with unmodified gold nanoparticle probes and multiple molecular logic gates.

A label-free strategy based on Fenton reaction with unmodified gold nanoparticles (AuNPs) as probe is demonstrated for ascorbic acid (AA) sensing. AuNPs is stable in the presence of single stranded DNA (ssDNA) which prevents salt-induced aggregation of AuNPs in solution. The hydroxyl free radicals generated by Fenton reaction lead to ssDNA cleavage into different sequence fragments which induce aggregation of AuNPs to produce a red-to-blue color change.

The inhibition of fluorescence resonance energy transfer between quantum dots for glucose assay.

Fluorescence resonance energy transfer (FRET) between two quantum dots of different sizes causes fluorescence quenching. Hereby a binding site pre-blocking approach is proposed to avoid this effect. Pre-binding of glucose on the donor occupies the binding sites and thus blocks resonance energy transfer between the two quantum dots, protecting the fluorescence from being quenched.

[Mechanism of cardioprotection induced by noninvasive limb ischemic preconditioning].

Objective: To verify the inhibitory effect of mitochondrial calcium uniporter in remote preconditioning-induced cardioprotection.

Methods: By occlusion and reperfusion of left anterior descending artery, the rat hearts were subjected to 30 min regional ischemia and 120 min reperfusion in vivo. Thus the ischemic reperfusion model was established.

[DSC and temperature-dependent infrared spectroscopic study of hydrogen-bonded liquid crystal complexes].

The hydrogen-bonded liquid crystalline complexes based on 4', 4-bipyridine and 4-(trans-4-propylcyclohexyl) benzoic acid and trans-4-(trans-4-propylcyclohexyl)cyclohexyl carboxylic acid assigned as PCBA-BPy and PCCA-BPy were prepared and measured by polarized optical microscopy (POM), differential scanning calorimeter (DSC) and temperature-dependent FTIR It was found that PCBA-BPy and PCCA-BPy exhibited both smectic and nematic phase while all of their predecessors showed no smectic phase. The temperature-dependent FTIR studies revealed that the hydrogen bonding in complex PCBA-BPy was very different from that in PCCA-BPy. The wave number of C=O band had an obvious change at the crystal 1-crystal 2 transition but almost didn't change at smectic-nematic and nematic-isotropic transition; while in PCCA-BPy, it showed no sudden changes but shift to 1 709 cm(-1) gradually with the increase in temperature.

[Changes of serum hepatocyte growth factor before and after percutaneous coronary intervention in patients with unstable angina pectoris and significance there].

Objective: To investigate the effect of unfitrate heparin (UFH) and low molecular weight heparin (LMWH) on the expression of serum hepatocyte growth factor (HGF) during percutaneous coronary intervention (PCI).

Methods: Seventy patients with chronic unstable angina pectoris were divided into 2 groups: PCI group (n = 49, with at least one main coronary artery branch with stenosis > or = 70%) and non-PCI group (n = 21, with the main coronary artery branch with stenosis < 70%). UFH was used at the beginning of coronary angiography in both groups and LMWH was used after PCI only in the PCI group.

Relationship between hs-CRP, proMMP-1, TIMP-1 and coronary plaque morphology: intravascular ultrasound study.

Background: Rupture of unstable plaque with subsequent thrombus formation is the common pathophysiological substrate of the acute coronary syndrome (ACS). It is of potential significance to explore the blood indexes predicting plaque characteristics. Little studies have focused on this field.

[C-reactive protein induced human endothelium cells apoptosis is associated with Bcl-2/Bax gene expression changes].

Objective: In the present study, we examined the expression changes of Bcl-2/Bax in C-reactive protein (CRP) treated human endothelium cells in vitro.

Methods: The human umbilical vein endothelial cells (HUVEC) were cultured by digest method for 2 - 3 posterities and incubated with human CRP (0, 1, 5, 25 mg/L for 24 hours) and analyzed by flow cytometer for apoptosis ratio. The effects of CRP in various concentrations on Bcl-2/Bax mRNA and protein expression were examined by RT-PCR and Western Blotting.

[Effects of puerarin on proliferation of vascular smooth muscle cells induced by thrombin].

Objective: To investigate the effects of puerarin on the proliferation of vascular smooth muscle cells (VSMC) induced by thrombin and the mechanism thereof.

Methods: VSMCs were isolated from the thoracic aorta of a SD rat and cultured, then co-cultured with thrombin of the concentration 0.1, 0.