Bioinformatics and experimental validation were combined to explore lactylation-related biomarkers in HBV-associated acute liver failure.

Background And Aim: Currently, hepatitis B virus-related acute liver failure (HBV-ALF) has limited treatment options. Studies have shown that histone lactylation plays a role in the progression of liver-related diseases. Therefore, it is essential to explore lactylation-related gene (LRGs) biomarkers in HBV-ALF to provide new information for the treatment of HBV-ALF.

Functional response and predation rate of Cryptolaemus montrouzieri (Coleoptera: Coccinellidae) to Paracoccus marginatus (Hemiptera: Pseudococcidae) at different temperatures.

The ladybug, Cryptolaemus montrouzieri (Mulsant) (Coleoptera: Cocccinellidae)(Mulsant)(Coleoptera: Cocccinellidae), is a highly efficient predator in controlling mealybug populations and is considered an effective agent for controlling the papaya mealybugs (Paracoccus marginatus) (Williams & Granara de Willink) (Hemiptera: Pseudococcidae). Various criteria have been proposed for evaluating predator effectiveness, with the consumption rate of prey by individual predators, specifically the functional response, emerging as a common and crucial metric. This study evaluated the functional responses of third- and fourth-instar larvae, as well as male and female adults (<48 h old) of C.

Solibacillus ferritrahens sp. nov., a novel siderophore-producing bacterium isolated from Wumeng Mountain National Nature Reserve in Yunnan Province.

A gram-stain-positive, aerobic, rod-shaped bacterial strain capable of producing siderophores, named YIM B08730, was isolated from a soil sample collected from Wumeng Mountain National Nature Reserve, Zhaotong City, Yunnan Province. Growth occurred at 10-45 °C (optimum, 35-40 ℃), pH 7.0-9.

Chitinolyticbacter albus sp. Nov., A Novel Chitin-Degrading Bacterium Isolated from Ancient Wood Rhizosphere Soil.

In this study, a novel aerobic mesophilic bacterial strain with capable of degrading chitin, designated YIM B06366, was isolated and classified. The rod-shaped, Gram-stain-negative, on-spore-forming bacterium originated from rhizosphere soil sample collected in Kunming City, Yunnan Province, southwest PR China. Strain YIM B06366 exhibited growth at temperatures between 20 and 35 °C (optimum, 30 °C) and at pH 6.

Pseudomonas subflava sp. nov., a new Gram-negative bacterium isolated from Guishan in Yunnan province, south-west China.

A new Gram-negative, rod-shaped, flagellated bacterium was isolated from soil in the Guishan, Xinping County, Yuxi City, Yunnan Province, China, and named YIM B01952. Growth occurred at 10-40 °C (optimum, 30 °C), pH 6.0-9.

Brevibacillus daliensis sp. nov., Isolated From Soil in Machangqing Nature Reserve.

A new aerobic bacterial strain, designated strain YIM B02290, was isolated from the soil of Machangqing, Dali city, Yunnan Province, China. Cells were Gram-stain-positive, sporogenous, rod-shaped, and motile with peritrichous flagella. Strain YIM B02290 showed the highest 16S rRNA gene sequence similarity with Brevibacillus laterosporus (97.

Sublethal and Transgenerational Toxicities of Chlorfenapyr on Biological Traits and Enzyme Activities of (Hemiptera: Pseudococcidae).

Papaya mealybug, Williams and Granara de Willink (Hemiptera: Pseudococcidae), is an economically important, invasive insect that is now distributed worldwide. Chlorfenapyr has been demonstrated to have a significant control effect on . In order to evaluate the sublethal and transgenerational effects of chlorfenapyr on , the life table data of three consecutive generations were collected and analyzed by the age stage, two-sex life table method, and the enzyme activities were assayed using a spectrophotometer.

Fitness of the Papaya Mealybug, (Hemiptera: Pseudococcidae), after Transferring from to , , and .

The papaya mealybug, Williams and Granara de Willink (Hemiptera: Pseudococcidae), is a polyphagous invasive pest in China. The effect that the shifting of the host plant has on the fitness of a polyphagous pest is critical to its prevalence and potential pest control. In order to assess the fitness changes of .

Cohnella mopanensis sp. nov., a new Gram-negative bacterium isolated from soil in Xinping Mountain National Forest Park.

A Gram-stain-negative, aerobic, rod-shaped bacteria strain, named YIM B01951, was isolated from a forest soil sample collected from Mopan Mountain National Forest Park, Xinping City, Yunnan Province, southwest PR China (101°58'06" N, 23°03'02" E). Growth occurred at 15-40 °C (optimum, 30 °C), pH 5.0-8.

Dual Differential Grouping: A More General Decomposition Method for Large-Scale Optimization.

Cooperative coevolution (CC) algorithms based on variable decomposition methods are efficient in solving large-scale optimization problems (LSOPs). However, many decomposition methods, such as the differential grouping (DG) method and its variants, are based on the theorem of function additively separable, which may not work well on problems that are not additively separable and will result in a bottleneck for CC to solve various LSOPs. This deficiency motivates us to study how the decomposition method can decompose more kinds of separable functions, such as the multiplicatively separable function, to improve the general problem-solving ability of CC on LSOPs.

Distributed Differential Evolution With Adaptive Resource Allocation.

Distributed differential evolution (DDE) is an efficient paradigm that adopts multiple populations for cooperatively solving complex optimization problems. However, how to allocate fitness evaluation (FE) budget resources among the distributed multiple populations can greatly influence the optimization ability of DDE. Therefore, this article proposes a novel three-layer DDE framework with adaptive resource allocation (DDE-ARA), including the algorithm layer for evolving various differential evolution (DE) populations, the dispatch layer for dispatching the individuals in the DE populations to different distributed machines, and the machine layer for accommodating distributed computers.

Surrogate-Assisted Hybrid-Model Estimation of Distribution Algorithm for Mixed-Variable Hyperparameters Optimization in Convolutional Neural Networks.

The performance of a convolutional neural network (CNN) heavily depends on its hyperparameters. However, finding a suitable hyperparameters configuration is difficult, challenging, and computationally expensive due to three issues, which are 1) the mixed-variable problem of different types of hyperparameters; 2) the large-scale search space of finding optimal hyperparameters; and 3) the expensive computational cost for evaluating candidate hyperparameters configuration. Therefore, this article focuses on these three issues and proposes a novel estimation of distribution algorithm (EDA) for efficient hyperparameters optimization, with three major contributions in the algorithm design.

Spatio-temporal distribution patterns of Plutella xylostella (Lepidoptera: Plutellidae) in a fine-scale agricultural landscape based on geostatistical analysis.

A detailed knowledge on the spatial distribution of pests is crucial for predicting population outbreaks or developing control strategies and sustainable management plans. The diamondback moth, Plutella xylostella, is one of the most destructive pests of cruciferous crops worldwide. Despite the abundant research on the species's ecology, little is known about the spatio-temporal pattern of P.

Generation-Level Parallelism for Evolutionary Computation: A Pipeline-Based Parallel Particle Swarm Optimization.

Due to the population-based and iterative-based characteristics of evolutionary computation (EC) algorithms, parallel techniques have been widely used to speed up the EC algorithms. However, the parallelism usually performs in the population level where multiple populations (or subpopulations) run in parallel or in the individual level where the individuals are distributed to multiple resources. That is, different populations or different individuals can be executed simultaneously to reduce running time.

Data-Driven Evolutionary Algorithm With Perturbation-Based Ensemble Surrogates.

Data-driven evolutionary algorithms (DDEAs) aim to utilize data and surrogates to drive optimization, which is useful and efficient when the objective function of the optimization problem is expensive or difficult to access. However, the performance of DDEAs relies on their surrogate quality and often deteriorates if the amount of available data decreases. To solve these problems, this article proposes a new DDEA framework with perturbation-based ensemble surrogates (DDEA-PES), which contain two efficient mechanisms.

Rosamultin Attenuates Acute Hypobaric Hypoxia-Induced Bone Injuries by Regulation of Sclerostin and Its Downstream Signals.

Wang, Xing-Min, Hui Liu, Jian-Yu Li, Jin-Xia Wei, Xia Li, Yong-Liang Zhang, Ling-Zhi Li, and Xi-Zheng Zhang. Rosamultin attenuates acute hypobaric hypoxia-induced bone injuries by regulation of sclerostin and its downstream signals. 21:273-286, 2020.

Euscaphic acid and Tormentic acid protect vascular endothelial cells against hypoxia-induced apoptosis via PI3K/AKT or ERK 1/2 signaling pathway.

Aims: Euscaphic acid and Tormentic acid are aglycones of Kaji-ichigoside F1 and Rosamultin, respectively. These four compounds are pentacyclic triterpenoid, isolated from the subterranean root of the Potentilla anserina L. Based on the protective roles against hypoxia-induced apoptosis of Euscaphic acid and Tormentic acid in vascular endothelial cells, this study was designed to determine the mechanisms.

Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson's Disease.

Purpose: The aim of this study was to compare the neuronal firing rate and oscillatory activity of the subthalamic nucleus (STN) between the more affected (MA) and the less affected (LA) hemispheres in Parkinson's disease (PD).

Patients And Methods: We recorded and analyzed the intra-operative microelectrode recordings (MER) from the STN of 24 PD subjects. Lateralized Unified Parkinson's Disease Rating Scale (UPDRS) III sub-scores (item 20-26) were calculated.

Possible involvement of alpha B-crystallin in the cardioprotective effect of n-butanol extract of Potentilla anserina L. on myocardial ischemia/reperfusion injury in rat.

Background: It has been reported that n-butanol extract of Potentilla anserina L (NP) had protective effect against acute myocardial ischemia/reperfusion (I/R) injury in mice. Because of limited phytochemical study on NP, its bioactive compounds and underlying protective mechanisms are largely unclear.

Purpose: The purpose of this study was to investigate the major bioactive compounds and possible mechanism for the cardioprotective effect of NP on rat with I/R injury.

Indirect Effect of Elevated CO2 on Population Parameters and Growth of Agasicles hygrophila (Coleoptera: Chrysomelidae), a Biocontrol Agent of Alligatorweed (Amaranthaceae).

Alligatorweed, Alternanthera philoxeroide (Mart.) Griseb. (Amaranthaceae) is an invasive weed in China that is often kept under control by the alligatorweed flea beetle, Agasicles hygrophila Selman and Vogt (Coleoptera: Chrysomelidae) introduced into China from Argentina in the 1980s.

Protective Effect of Rosamultin against HO-Induced Oxidative Stress and Apoptosis in H9c2 Cardiomyocytes.

Rosamultin is one of the main active compounds isolated from L., which belongs to a triterpene compound. Few studies have examined the effect of rosamultin on oxidative stress and its molecular mechanism.