Publications by authors named "Li-gong Lu"
Article Synopsis
- The study presents a new method using macroporous resin chromatography to efficiently enrich four active diterpenoid components from the buds of Wikstroemia chamaedaphne.
- The D101 macroporous resin demonstrated the highest performance for the adsorption and purification of these bioactive compounds.
- Analysis showed that the enriched diterpenoid extracts have effective properties for activating latent HIV, suggesting a potential for developing low-toxicity agents for clinical applications.
Transarterial embolization, the first-line treatment for hepatocellular carcinoma, does not always lead to promising outcomes in all patients. A better understanding of how the immune lymphocyte changes after transarterial embolization might be the key to improve the efficacy of transarterial embolization. However, there are few studies evaluating immune lymphocytes in transarterial embolization patients.
View Article and Find Full Text PDFArticle Synopsis
- - Oxabornyl polyenes are a special type of polyketide found in fungi, featuring a distinct polyene core and diverse oxygen-containing rings, with known biological activities but complex configurations.
- - The study isolated three specific oxabornyl polyenes (prugosenes A1-A3) from a fungal strain and used ozonolysis and ECD calculations to determine their absolute configurations, which were previously unassigned.
- - The prugosenes showed strong antiviral effects against the respiratory syncytial virus, with a notable effectiveness of 6.3 μM for one of the compounds, contributing to a better understanding of these compounds and their potential uses.
Article Synopsis
- The study investigates the effectiveness and safety of using small-sized (≤ 100 μm) drug-eluting beads loaded with epirubicin in transarterial chemoembolization (DEB-TACE) for treating hepatocellular carcinoma (HCC).
- A total of 108 patients were enrolled across ten centers, showing a 6-month objective response rate of 73.3% based on EASL criteria, with positive outcomes in various follow-up measures including overall survival rates.
- The trial concluded that DEB-TACE with these small microspheres presents a promising approach for local tumor control in HCC with manageable safety concerns.
Article Synopsis
- Chinese cordyceps, or Dong-Chong-Xia-Cao, is a prized herb in traditional Chinese medicine, known for supporting the immune system and enhancing lung and kidney functions, along with having anti-tumor and anti-diabetic properties.
- Despite its rarity, many of its active chemical components overlap with those found in other resources, leaving numerous compounds still unidentified.
- A new compound called cordythiazole A was discovered in cordyceps, marking the first thiazole alkaloid identified in this herb, showing promising anti-diabetes effects similar to acarbose.
Background And Aim: Treatment strategy for hepatocellular carcinoma (HCC) and Vp4 [main trunk] portal vein tumor thrombosis (PVTT) remains limited due to posttreatment liver failure. We aimed to assess the efficacy of irradiation stent placement with 125 I plus transcatheter arterial chemoembolization (TACE) (ISP-TACE) compared to sorafenib plus TACE (Sora-TACE) in these patients.
Methods: In this multicenter randomized controlled trial, participants with HCC and Vp4 PVTT without extrahepatic metastases were enrolled from November 2018 to July 2021 at 16 medical centers.
Article Synopsis
- This study evaluates the combined effectiveness of transarterial chemoembolization (TACE) with PD-(L)1 inhibitors and molecular targeted treatments (MTT) compared to TACE alone in treating hepatocellular carcinoma (HCC).
- It involved 826 patients, with 376 receiving the combination treatment and 450 undergoing TACE monotherapy, and measured outcomes like progression-free survival (PFS) and overall survival (OS).
- Findings indicated that the combination treatment significantly improved PFS (9.5 months vs. 8.0 months) and OS (19.2 months vs. 15.7 months) while maintaining a manageable safety profile, especially in patients with advanced HCC.
Article Synopsis
- * Researchers isolated several new modified daphnane- and tigliane-type diterpenes from the plant Wikstroemia chamaedaphne, some of which show significant HIV latency-reversing activity.
- * Key compounds, particularly chamaedaphnelide B, were found to effectively reactivate latent HIV by significantly activating STAT1, highlighting a potential therapeutic pathway for treatment.
γδ T cells are one of only three immune cell types that express antigen receptors that undergo somatic recombination, and they contribute to immune responses to infection, cellular transformation, and tissue damage. As a "bridge" between the innate and adaptive immune systems, γδ T cells have been noted to be involved in various immune responses during cancer progression. The purpose of our study was to review current published information on γδ T cells and investigate their functions in different types of malignancy using bibliometric and bioinformatic methods.
View Article and Find Full Text PDFArticle Synopsis
- The addition of paclitaxel significantly increased the stent's strength, and the drug was effectively released during degradation, promoting fibroblast apoptosis without harming cell viability.
- In animal studies, the new stent maintained esophageal opening and reduced inflammation and scar tissue, indicating its potential as a safe treatment for benign esophageal strictures.
Objective: Patients with increased PD-L1 host cells in tumours are more potent to benefit from antiprogrammed death-1/programmed death ligand-1 (PD-L1) treatment, but the underlying mechanism is still unclear. We aim to elucidate the nature, regulation and functional relevance of PD-L1 host cells in hepatocellular carcinoma (HCC).
Design: A total of untreated 184 HCC patients was enrolled randomly.
CT-based radiomics to predict development of macrovascular invasion in hepatocellular carcinoma: A multicenter study.
Hepatobiliary Pancreat Dis Int
August 2022
Background: Macrovascular invasion (MaVI) occurs in nearly half of hepatocellular carcinoma (HCC) patients at diagnosis or during follow-up, which causes severe disease deterioration, and limits the possibility of surgical approaches. This study aimed to investigate whether computed tomography (CT)-based radiomics analysis could help predict development of MaVI in HCC.
Methods: A cohort of 226 patients diagnosed with HCC was enrolled from 5 hospitals with complete MaVI and prognosis follow-ups.
Background: Malignant peripheral nerve sheath tumor (MPNST) is a type of spindle cell sarcoma originating from the peripheral nerve, which usually results in the corresponding nerve sign on magnetic resonance imaging (MRI). Patients with MPNST may also have neurofibromatosis type 1.
Case Summary: A 78-year-old male was admitted to the hospital due to a tumor in his left knee.
The combination of chemotherapy and radiotherapy (chemoradiotherapy) is a promising strategy, extensively studied and applied clinically. Meanwhile, radiosensitizers play an important role in improving clinical radiotherapy therapeutic efficacy. There are still some disadvantages in practical applications, because radiosensitizers and drugs are difficult to deliver spatio-temporally to tumor sites and work simultaneously with low efficiency for DNA damage and repair inhibition, leading to an inferior synergistic effect.
View Article and Find Full Text PDFArticle Synopsis
- A retrospective study was conducted to examine the safety and effectiveness of using absolute ethanol with n-butyl cyanoacrylate for treating advanced venous malformations in children, performed at a medical center in Guangzhou, China, from 2009 to 2014.
- Out of 121 children treated, 21 cases were identified as advanced Puig's venous malformation, and treatment led to a 71% success rate in controlling the malformations after an average follow-up of 15 months.
- The study reported a low complication rate of 14.3%, with mostly minor issues, suggesting that the combined sclerotherapy method is a promising option for managing these vascular conditions in pediatric patients.
Activation of MET promotes resistance to sorafenib in hepatocellular carcinoma cells via the AKT/ERK1/2-EGR1 pathway.
Artif Cells Nanomed Biotechnol
December 2019
Sorafenib is an oral multikinase inhibitor that has become an established therapeutic approach in advanced hepatocellular carcinoma (HCC). However, the benefit of sorafenib in clinical therapy is often affected by drug resistance. Therefore, it is important to explore the mechanisms underlying sorafenib resistance and to develop individualized therapeutic strategies for coping with this problem.
View Article and Find Full Text PDFArticle Synopsis
- Hepatocellular carcinoma (HCC) accounts for 85-90% of primary liver cancer cases in China, largely due to widespread chronic hepatitis B infection, making it a major health issue.* -
- The National Health and Family Planning Commission of China released guidelines crafted by over 50 HCC experts, addressing surveillance, diagnosis, staging, and treatment strategies for HCC.* -
- The guidelines include a Chinese staging system and recommendations aimed at optimizing patient outcomes for individuals with HCC in China.*
Metadherin (MTDH) is a multifunctional oncogene involved in tumor cell migration and metastasis through regulating a number of oncogenic signaling pathways in various human malignancies. Previous studies have demonstrated that MTDH is overexpressed in human colorectal cancer (CRC) and associated with cancer progression and a poor prognosis. However, the underlying mechanisms remain largely unknown.
View Article and Find Full Text PDFThis work aims to study the roles and related mechanisms of six2 in 5-FU sensitivity of hepatocellular carcinoma (HCC) cells. KM-Plotter analysis showed that HCC patients with higher six2 expression levels had shorter overall survival. Six2 expression was higher in clinical HCC tissues than in normal tissues, and was negatively correlated with E-cadherin expression.
View Article and Find Full Text PDFThe aim of the present study was to investigate the prognostic potential of a novel inflammation-based system, the combination of the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) (CNP), for predicting the survival time of patients with hepatocellular carcinoma (HCC) who had received radiofrequency ablation (RFA). A total of 287 HCC patients treated with RFA were enrolled in the study. Patients with an elevated NLR (>2.
View Article and Find Full Text PDFPurpose: We adopted a new strategy to explore the relationship between the EMT process of CTCs and hepatocellular carcinoma (HCC). Furthermore, we intend to illustrate the potential diagnostic value of CTCs of distinct phenotypes in HCC.
Methods: The clinical data of 33 HCC patients and 10 healthy volunteers were collected retrospectively.
Purpose: To assess whether urea-based cream (UBC) has prophylactic benefits on sorafenib-induced hand-foot skin reaction (HFSR) in patients with advanced hepatocellular carcinoma (HCC).
Patients And Methods: In this randomized, open-label trial, 871 patients with advanced HCC throughout China were treated with 10% UBC three times per day plus best supportive care (BSC; n = 439) or BSC alone excluding all creams (n = 432), starting on day 1 of sorafenib treatment, for up to 12 weeks. HFSR was assessed every 2 weeks and at 14 weeks for patients completing the study.
Objectives: It was the aim of this study to find an optimal therapeutic regimen of transarterial chemoembolization (TACE) by comparing the efficacy of chemoembolization with different anticancer agents in hepatocellular carcinoma (HCC) patients.
Methods: A single-blind, three-group parallel, randomized trial was conducted in Guangdong General Hospital, Guangzhou, China, with patients with biopsy-confirmed HCC. Group 1 received single-drug (doxorubicin) chemoembolization, while group 2 received double-drug (doxorubicin and mitomycin C) chemoembolization.
Aim: To evaluate the efficacy and safety of arsenic trioxide transarterial chemoembolization and intravenous administration in unresectable hepatocellular carcinoma with lung metastasis.
Methods: A single-blind, two-parallel group, randomized trial was conducted at three medical centers (Guangzhou, China), including patients with both biopsy-confirmed hepatocellular carcinoma and lung metastasis. The experimental group received arsenic trioxide transarterial chemoembolization and intravenous administration of arsenic trioxide, while the control group only received arsenic trioxide transarterial chemoembolization.
Article Synopsis
- KDR is a key receptor involved in promoting blood vessel growth and is a target for treatments aimed at inhibiting angiogenesis; this study investigates the impact of genetic variations (SNPs) in the KDR gene on treatment outcomes for advanced liver cancer patients.
- In a study of 78 patients on first-line sorafenib therapy, specific KDR genotypes (AA in rs1870377 and rs2305948) were linked to better treatment responses and longer time to disease progression.
- The findings indicate that certain SNPs in the KDR gene could serve as biomarkers to predict survival outcomes in advanced hepatocellular carcinoma patients undergoing sorafenib therapy.