Diagnostic value of neuronal pentraxin II methylation in patients with pancreatic cancer: Meta-analysis.

Background: Pancreatic cancer (PC) is a devasting disease of which mortality almost parallels its incidence. PC tissue may express aberrantly methylated neuronal pentraxin II (NPTX2), but it is unclear what the consequences of this are.

Methods: We systematically searched PubMed, Web of Science, the Chinese National Knowledge Infrastructure (CNKI), from inception to July 15, 2020, to identify if the detection of methylated NPTX2 have sufficient sensitivity and specificity to identify PC from other benign pancreatic diseases.

[The value of flow cytometry for the differential diagnosis between refractory cytopenia with multiple dysplasia and aplastic anemia].

Objective: To evaluate the value of flow cytometry (FCM) for the differential diagnosis between myelodysplasia (MDS) subtype refractory cytopenia with multiple dysplasia (RCMD) and aplastic anemia (AA).

Methods: The flow cytometric data of bone marrow samples from 168 cases of RCMD and 77 cases of AA were analyzed retrospectively in blind, and its results were compared with gold standard to evaluate its diagnosis values.

Results: The specificity of abnormal of single immunophenotype in the surface of granulocytes and myeloblasts was high (range 75.