V4+ T Cells: A Novel IL-17-Producing T Subsets during the Early Phase of Chlamydial Airway Infection in Mice.

Our previous studies showed that T cells provided immune protection against Chlamydial (Cm), an obligate intracellular strain of chlamydia trachomatis, lung infection by producing abundant IL-17. In this study, we investigated the proliferation and activation of lung T cell subsets, specifically the IL-17 and IFN production by them following Cm lung infection. Our results found that five T cell subsets, V1+ T, V2+ T, V4+ T, V5+ T, and V6+ T, expressed in lungs of naïve mice, while Cm lung infection mainly induced the proliferation and activation of V4+ T cells at day 3 p.

Transactivation of proto-oncogene c-Myc by hepatitis B virus transactivator MHBs.

C-terminally truncated hepatitis B virus (HBV) middle size surface proteins (MHBs) has been shown to be a transcriptional activator and may be relevant to hepatocarcinogenesis by transactivating gene expression. In the present study, a pcDNA3.1(-)-MHBs vector coding for MHBs truncated at amino acid 167 (MHBs) was constructed and transfected into the HepG2 hepatoma cell line.