Publications by authors named "Li-da Mo"
Article Synopsis
- SARS-CoV-2 variants pose a serious health threat, leading to high rates of illness and death, prompting the need for genomic analysis.
- Next-generation sequencing and phylogenetic analysis were used to study 80 SARS-CoV-2 genomes from COVID-19 patients, revealing a novel variant with specific mutations in the spike glycoprotein.
- These mutations (H625R and S50L) could enhance the spike protein's flexibility and potentially alter its interaction with the ACE2 receptor, indicating ongoing evolution of the virus.
Article Synopsis
- * A study analyzed 118 patients with confirmed SARS-CoV-2 infections to assess various clinical indicators during their hospital stay.
- * Findings revealed that specific blood markers (high ALT, AST, low CD4+, CD8+) correlated with a longer duration of detectable viral RNA, suggesting these indicators may help predict how long a patient will carry the virus.
Objective: This study aims to investigate the prevalence and types of drug resistance mutations among patients failing first-line antiretroviral therapy (ART).
Methods: Plasma samples from 112 patients with human immunodeficiency virus-1 (HIV-1) were collected for virus RNA extract and gene amplification. The mutations related to drug resistance were detected and the incidence was statistically analyzed, and the drug resistance rate against common drugs was also evaluated.