Stem signatures associated antibodies yield early diagnosis and precise prognosis predication of patients with non-small cell lung cancer.

Background: This study was designed to detect patients with early NSCLC with tentatively using the stem signatures associated autoantibodies (AAbs), and to evaluate its latent values in the early diagnosis and precise prognosis prediction.

Methods: The serum concentrations of selective antibodies were quantitated by enzyme-linked immunosorbent assay (ELISA), and a total of 458 cases were enrolled (training set = 401; validation set = 57). TCGA databases were used to analyze the distinct expressions and prognostic values of related genes.

Association mapping and favourable QTL alleles for fibre quality traits in Upland cotton (Gossypium hirsutum L.).

Improving cotton fibre quality is a major breeding goal for Upland cotton in China.To investigate the genetic mechanisms of fibre quality, a diverse panel of 403 Upland cotton accessions was grown, and the fibre quality traits were measured in six different environments. Genotyping was performed with genomewide simple sequence repeats.

[Changes of aquaporins 1 expression in the contused lung of rats].

Objective: To investigate the expression changes of aquaporins 1 (AQP1) in contused lung tissue of rats and its relationship with pulmonary edema.

Methods: SD rats were randomly divided into experimental and control groups. The pulmonary contusion models were then prepared.

[Apoptosis in myocardial cells after macleaya cordata total alkaloids poisoning in rats].

Objective: To observe pathological changes and apoptosis in rats myocardial cells after Macleaya cordata total alkaloids poisoning, and to provide some references for Macleaya cordata total alkaloids poisoning detection.

Methods: An experimental model of Macleaya cordata total alkaloids poisoning was established, and the technology of TUNEL staining was used.The results were analyzed by computer image analysis competitive system.

[Experimental pathological study of acute intoxication by Chloranthus serratus Roem. Et Schalt].

Objective: To find out the pathological change and the toxic mechanism of Chloranthus serratus Roem. et Schalt in mice.

Methods: Mice were intoxicated by oral administration with extracts of Chloranthus serratus Roem.

[The expression of dystrophin in human viral myocarditis and dilated cardiomyopathy].

Objective: In order to improve the accuracy and reliability in sudden cardiac death, the pathogenesis and relationship between the viral myocarditis and dilated cardiomyopathy were investigated.

Methods: Improved immunohistochemical technique was adopted to detect the expression of the dystrophin in myocardium from 25 viral myocarditis, 28 dilated cardiomyopathy and 17 control cases including normal, coronary atherosclerotic heart disease and hypertension heart disease as control.

Results: The positive rate of dystrophin protein expression in control group was 100%, that in viral myocarditis was 88%, and that in dilated cardiomyopathy was 57%, There were significant differences among three groups (P<0.

[Experimental pathological study of subacute intoxication by Dioscorea bulbifera L].

Objective: To study the pathological change and the toxic mechanism of Dioscorea bulbifera L in mice.

Methods: Sixty ICR mice were randomly assigned to four groups poisoned respectively with 200% Dioscorea bulbifera L of 1/4 LD50, 1/10LD50, 1/30LD50 and a control group treated with distilled water by oral administration. All animals were pathologically examined with LM and some of them were examined with TEM when the mice died during the experiment or the survival mice were sacrificed after thirty days.