Gene signatures to therapeutics: Assessing the potential of ivermectin against t(4;14) multiple myeloma.

Background: Multiple myeloma (MM) is a terminal differentiated B-cell tumor disease characterized by clonal proliferation of malignant plasma cells and excessive levels of monoclonal immunoglobulins in the bone marrow. The translocation, (t)(4;14), results in high-risk MM with limited treatment alternatives. Thus, there is an urgent need for identification and validation of potential treatments for this MM subtype.

Polarization control strategy of a laser communication terminal with a periscopic scanner using dual rotating waveplates.

We assessed the problem of low mixing efficiency caused by unstable signal polarization because of a moving reflector in a laser communication terminal with a periscopic scanner. A real-time polarization compensation method based on rotating waveplates is presented, which keeps the receiving signal light polarization at 45° linear polarized and improves system mixing efficiency. A geometric model of the laser communication terminal was first established, its polarization transmission characteristics were analyzed by three-dimensional polarization tracks, and a system polarization transmission matrix was calculated.

Determination of phthalate esters in airborne particulates by heterogeneous photo-Fenton catalyzed aromatic hydroxylation fluorimetry.

The environmental contaminants phthalic acid esters (PAEs) were determined by aromatic hydroxylation fluorimetry combined with heterogeneous photo-Fenton process in the presence of vermiculite supported BiFeO (VMT-BiFeO). In strong alkaline solution, PAEs were hydrolyzed into phthalates with no fluorescence, which then reacted with hydroxyl free radicals produced in photo-Fenton process catalyzed by VMT-BiFeO to form the fluorescent hydroxyl phthalates. The fluorescence intensity was proportional to the concentration of PAEs with the maximum excitation and emission wavelength of 300nm and 417nm, respectively.