Inhibition of Obtusifolin on retinal pigment epithelial cell growth under hypoxia.

Aim: To explore the effect of Obtusifolin on retinal pigment epithelial cell growth under hypoxia.

Methods: chemical hypoxia model of ARPE-19 cells was established using cobalt chloride (CoCl). Cell viability was tested by cell counting kit-8 (CCK-8) assay.

Spatholobi Caulis extracts promote angiogenesis in HUVECs in vitro and in zebrafish embryos in vivo via up-regulation of VEGFRs.

Ethnopharmacological Relevance: Spatholobi Caulis is a traditional blood-activating and stasis-dispelling herb medicine, which has been used to treat diseases related to blood stasis syndrome (BSS) by inhibiting platelet aggregation, stimulate hematopoiesis, etc. It has been demonstrated that pro-angiogenesis could improve BSS. However, the pro-angiogenic activity of Spatholobi Caulis was not well elucidated AIM OF STUDY: To determine the potential pro-angiogenic activity of Spatholobi Caulis and elucidate its underlying mechanism.