G-quadruplex from precursor miR-1587 modulated its maturation and function.

A certain proportion of pre-miRNAs, which contained potential G-quadruplex forming sequences, was found to act as a mediator to Dicer-mediated cleavage, and that the regulation of miRNA production and function may be achieved through the G-quadruplex structure. In this study, human precursor miR-1587 sequence was transfected after the incubation with different solution conditions (K, TMPyP4, etc.).

Persistence of an epidemic cluster of in multiple geographic regions in China and the emergence of a 5-flucytosine resistant clone.

, an environmental yeast widely used in industry and agriculture, is also an opportunistic pathogen resistant to multi-antifungals. During the national surveillance in China, has been documented from various hospitals and regions. At present, the molecular epidemiology of invasive infections caused by and their resistance profiles to antifungals were unknown.

Antifungal Susceptibility Profiles and Resistance Mechanisms of Clinical Isolates With High MIC Values.

() is an ascomycete yeast species widely used in environmental and industrial research and capable of causing infections in humans and animals. At present, there are only a few studies on , and further research is required for its more in-depth characterization and analysis. Eleven strains of collected from China Hospital Invasive Fungal Surveillance Net (CHIF-NET) and the CHIF-NET North China Program were identified using matrix-assisted laser desorption ionization-time of flight mass spectrometry and internal transcribed spacer sequencing.

Effect of ulipristal acetate and mifepristone at emergency contraception dose on the embryo-endometrial attachment using an in vitro human trophoblastic spheroid and endometrial cell co-culture model.

Study Question: Do both ulipristal acetate (UPA) and mifepristone inhibit embryo-endometrial attachment at concentrations corresponding to the emergency contraception (EC) dose?

Summary Answer: Both UPA and mifepristone at concentrations corresponding to the EC dose do not have an inhibitory effect on embryo implantation, although mifepristone at a higher concentration appeared to have such an effect.

What Is Known Already: Levonorgestrel is commonly used for EC, but it only acts through inhibition of ovulation. UPA and mifepristone have higher efficacy as EC compared to levonorgestrel; while there is some suggestion that mifepristone may interfere with implantation, whether UPA has post-ovulatory action in inhibiting implantation is yet to be confirmed.

Shape of concentration-response curves between long-term particulate matter exposure and morbidities of chronic bronchitis: a review of epidemiological evidence.

Numerous studies have assessed the concentration-response (C-R) relationships between long-term exposure to particulate matter (PM) and mortality from cardiopulmonary diseases, but few studies have evaluated the C-R relationships between PM exposure and morbidity of chronic respiratory diseases or their symptoms, and to date no systematic review has been published on the characteristics of the C-R curves between PM exposure and respiratory disease morbidity. Screening of all available studies in Medline identified ten studies with figures or scatter plots showing the C-R relationships between PM exposure and chronic bronchitis or chronic cough/phlegm. The C-R relationships showed ballistic 'S' shaped curves, linear in the low to moderate PM range and flattening out in the high PM range.

[Prevalence, awareness, treatment and control of hypertension in rural adult residents of Liaoning Province].

Objective: The objective of this study was to estimate the current status of prevalence, awareness, treatment and control rate of hypertension in adult residents living in rural area of Liaoning Province, North China.

Methods: The screening was finished in 2008, probability proportional to size sampling method was used to select the representative sample. Blood pressure was measured in 153481 adults (aged > 35 yr), information on history of hypertension and use of antihypertensive medications was obtained by use of a standard questionnaire.

Influence of the Wenchuan earthquake on self-reported irregular menstrual cycles in surviving women.

Objective: To explore the influence of stress induced by the Wenchuan earthquake on the menstrual cycles of surviving women.

Methods: Self-reports of the menstrual cycles of 473 women that survived the Wenchuan earthquake were analyzed. Menstrual regularity was defined as menses between 21 and 35 days long.