Biomimetic mineralization of hydrated magnesium carbonate for hydrogel reinforcement and heavy metal adsorption.

With excessive Mn(Ⅱ) and Cu(Ⅱ) pollution in aquatic environments posing potential health risks to inhabitants, the emergence of carbon capture, utilization and storage (CCUS) technology has promoted the improvement of heavy metal remediation technologies. Using hydrothermal sediment as a crystal seed, rhamnolipid was used to mediate biomimetic mineralization to prepare hydrated magnesium carbonate (HMC) composites to enhance the Mn(Ⅱ)/Cu(Ⅱ) adsorption performance of alginate hydrogels. Hydrothermal sediment is beneficial for accelerating biomimetic mineralization, while rhamnolipid can induce a crystalline phase transformation from dypingite to nesquehonite.

Contrasting fate and binding behavior of Mn and Cu with dissolved organic matter during in situ remediation using multicomponent capping in malodorous black water.

The common use of peroxides in the remediation of malodorous black water may lead to the activation of heavy metals in sediment when eliminating black and odorous substances. The mechanisms of heavy metal interactions with dissolved organic matter (DOM) in response to in situ capping have not been elucidated, but this information could guide the optimization of capping materials. We developed a capping material consisting of hydrothermally carbonized sediment (HCS), hydrated magnesium carbonate (HMC) and sodium percarbonate (SPC) and used microcosm experiments to investigate the dynamics of Mn and Cu at the sediment-water interface in malodorous black water.

Formyl phloroglucinol meroterpenoids from the leaves of Eucalyptus globulus subsp. maidenii and their ATP-citrate lyase inhibitory activities.

Three new formyl phloroglucinol meroterpenoids, eumaidials A-C (1-3), were isolated from the leaves of Eucalyptus globulus subsp. maidenii, along with ten known analogues (4-13). Their chemical structures were determined by various spectral data and electronic circular dichroism calculations.

Refining the diagnostics of non-point source metals pollution to urban lakes based on interaction normalized PMF coupled with Bayesian network.

Spatiotemporal variability complicates source apportionment of metals in urban lakes, especially when rainfall drives urban non-point source pollution. As, Cd, Cr, Pb, Hg, Ag, Co, Cu, Fe, Mn, Ni, Sb, Sr and Zn concentrations in 648 water samples collected before and after rain in 6 urban lakes of Beijing, China were determined during 2013-2015. The response of metals concentrations after rain to the interaction between rainfall and antecedent dry days was significant.

Effect of Alkali and 1,4-Butanediol Contents on the Extraction of Lignin and Lignin-Based Activated Carbon.

In the process of lignin extraction by the organic solvent method, the amount of alkali and the content of 1,4-butanediol are important conditions that affect lignin yield. The effects of alkali and alcohol contents on lignin recovery, removal rate, and structure were studied. In this reaction system, the removal rate of lignin increased with the increase of alkali content but decreased with the increase of alcohol content.

Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus.

Fatty acid-binding protein 4 (FABP4) and fatty acid-binding protein 5 (FABP5) are promising therapeutic targets for the treatment of various metabolic diseases. However, the weak potency, low selectivity over FABP3, or poor pharmacokinetic profiles of currently reported dual FABP4/5 inhibitors impeded further research. Here, we described the characterization of a series of dual FABP4/5 inhibitors with improved metabolic stabilities and physicochemical properties based on our previous studies.

Response of antimony distribution in street dust to urban road traffic conditions.

Little is known about the relationship between traffic congestion and antimony (Sb) distribution in street dust, which is essential for Sb control and emission reduction in urban areas. Sb concentrations and mass load of the street dust collected in 19 cities of China were determined before investigating the mechanism of traffic influence on Sb distribution through diverse statistical means. The results showed that the Sb concentrations in each city were 1.

Combined treatment with FABP4 inhibitor ameliorates rosiglitazone-induced liver steatosis in obese diabetic db/db mice.

Rosiglitazone has been reported to exert dual effects on liver steatosis, and it could exacerbate liver steatosis in obese animal models, which was suggested to be closely related to the elevated hepatic expression of FABP4. This study aimed to investigate whether combined treatment with FABP4 inhibitor I-9 could alleviate rosiglitazone-induced liver steatosis in obese diabetic db/db mice. Male C57BL/KsJ-db/db mice were orally treated with rosiglitazone, rosiglitazone combined with I-9 daily for 8 weeks.

Lead distribution in urban street dust and the relationship with mining, gross domestic product GDP and transportation and health risk assessment.

Lead (Pb) is an important pollutant and it is of significance to explore the Pb distribution, influencing factors and health risk. Pb concentration and mass load per unit area in 385 street dust samples collected from 19 cities in China were determined during 2011-2013. The results show that the Pb concentration are 68.

Preparation of Syringaldehyde from Lignin by Catalytic Oxidation of Perovskite-Type Oxides.

The influence of different reaction conditions on the yield of syringaldehyde was studied by using perovskite oxide as the catalyst. The optimal reaction conditions are as follows: 0.60 g of dealkali lignin, 0.

Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes.

Purpose: Fatty acid binding protein 4 (FABP4) has been demonstrated to be secreted from adipocytes in an unconventional pathway associated with lipolysis. Circulating FABP4 is elevated in metabolic disorders and has been shown to affect various peripheral cells such as pancreatic β-cells, hepatocytes and macrophages, but its effects on adipocytes remains unclear. The aim of this study was to investigate the effects of exogenous FABP4 (eFABP4) on adipocyte differentiation and function.

Effectiveness of electroacupuncture for pain after osteosarcoma post surgery: A study protocol of systematic review of randomized controlled trial.

Background: This study will assess the effectiveness of electroacupuncture (EA) for pain in patients with osteosarcoma post surgery (OSPS).

Methods: In this study, we will comprehensively search the following electronic databases from inception to the present without language restrictions: Cochrane Library, EMBASE, MEDLINE, the Cumulative Index to Nursing and Allied Health Literature, the Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database. Two authors will independently carry out study selection, data extraction, and methodological assessments.

Dimeric 1,4-benzoquinone Derivatives with Cytotoxic Activities from the Marine-Derived Fungus sp. L129.

Two new dimeric 1,4-benzoquinone derivatives, peniquinone A () and peniquinone B (), a new dibenzofuran penizofuran A (), and a new pyrazinoquinazoline derivative quinadoline D (4), together with 13 known compounds (-), were isolated from a marine-derived fungus sp. L129. Their structures, including absolute configurations, were elucidated by extensive spectroscopic data and electronic circular dichroism calculations.

Acrepyrone A, a new -pyrone derivative from an endophytic fungus, SS-g13.

A new -pyrone derivative, acrepyrone A (), and three known sorbicillinoids, trichodimerol (), dihydrotrichodimerol () and tetrahydrotrichodimerol () were isolated from an endophytic fungus, SS-g13, harboured in the roots of the Chinese medicinal plant Their structures were determined by analysing MS, NMR, and ECD data. Compound was evaluated for its cytotoxic effect, antibacterial activity and quorum sensing inhibitory potential.

[Comparison of Characteristics and Source Apportionment of Polycyclic Aromatic Hydrocarbons in Different Environmental Media in the Urban Area of Daqing City].

In order to investigate the various pollution characteristics and sources of polycyclic aromatic hydrocarbons (PAHs) in different environmental media, 23 street dust samples and four soil samples were collected in October 2012 in Daqing City. After extraction by Dionex ASE300 and purification, the content of the US EPA priority pollutants[16 individual PAH and total PAHs (ΣPAHs)] was determined by using gas chromatography-mass spectrometry (GC/MS). The results showed that the range of ΣPAHs content in street dust was 579.

From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4.

Fatty acid binding protein 4 (FABP4) plays a critical role in metabolism and inflammatory processes and therefore is a potential therapeutic target for immunometabolic diseases such as diabetes and atherosclerosis. Herein, we reported the identification of naphthalene-1-sulfonamide derivatives as novel, potent and selective FABP4 inhibitors by applying a structure-based design strategy. The binding affinities of compounds 16dk, 16do and 16du to FABP4, at the molecular level, are equivalent to or even better than that of BMS309403.

Structural characteristics of natural chimeric genes and their implications for gene design.

The natural chimeric gene is a novel gene fused by two or more independent genes. Its discovery extends the classical gene concept that one gene resides in one chromosomal locus. During tumorigenesis, many chimeric genes lead to tumor-related diseases; therefore, it is one molecular marker for cancer diagnosis.

Integrated water resources management for emergency situations: A case study of Macau.

Integrated urban water management (IUWM) is a useful tool that can be used to alleviate water resource shortages in developing regions like Macau, where 98% of the raw water comes from mainland China. In Macau, scarce water resources deteriorate rapidly in emergency situations, such as accidental chemical spills upstream of the supply reservoir or salty tides. During these times, only the water from the two freshwater reservoirs in Macau can be used.

[Influence of Kudou Shencha decotion on INF-gamma, ICAM-1, MCP-1 levels of prostate tissue homogenate in immunity prostatitis model rats].

Objective: To investigate the influence of Kudou Shencha decotion on INF-y, ICAM-1, MCP-1 levels of prostate tissue homogenate in immunity prostatitis model rats.

Method: Forty Wistar male rats were divided into 5 groups randomly: Kudou Shencha decotion group with high dosage and low dosage, Qianleitai group, the model control group and normal group. The rat model of chronic nonbacterial prostatitis was established by multiple hypodermical injection of the suspension of prostatic protein purification with Freund's completed adjuvant.

[Post-stroke shoulder-hand syndrome treated with acupuncture and rehabilitation: a randomized controlled trial].

Objective: To assess the clinical efficacy on post-stroke shoulder-hand syndrome (SHS) treated with acupuncture and rehabilitation and the impacts on patients' nailfold microcirculation.

Methods: One hundred and twenty patients were randomized into an acupuncture rehabilitation group and a simple rehabilitation group, 60 cases in each one. In the simple rehabilitation group, OT (comprehensive rehabilitation therapy) training was adopted.

[Analysis and evaluation of heavy metals along the Chaohe River in Miyun County].

In order to explore the heavy metal concentrations in soils surrounding the Chaohe River, 15 soil samples were collected along the Chaohe River. Results show that average concentrations of As, Cd, Cr, Cu, Hg, Ni, Pb, Zn are 7.94, 0.

Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice.

Aim: Fatty acid-binding protein 4 (FABP4) plays an important role in maintaining glucose and lipid homeostasis. The aim of this study was to find new inhibitors of FABP4 for the treatment of type 2 diabetes.

Methods: Human FABP4 protein was expressed, and its inhibitors were detected in 1,8-ANS displacement assay.

Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors.

Twenty-four sugar-substituted oleanolic acid derivatives (1a-1f, 2a-2j, and 3a-3h) were synthesized in a concise and efficient strategy and their effects on the inhibition of protein tyrosine phosphatase 1B (PTP1B) and insulin-sensitizing response were evaluated in vitro. Several derivatives showed moderate to good inhibitory activities against PTP1B, and especially compounds 2f, 2h, 3d and 3e exhibited the most potent inhibitory activities with the IC50 values of 1.91, 12.

Cryptococcus nanyangensis sp. nov., a new basidiomycetous yeast isolated from the gut of wood-boring larvae.

Two strains of a novel basidiomycetous yeast species were isolated from the gut of wood-boring larvae collected in the Baotianman Nature Reserve, the central China. Sequence analysis of the D1/D2 domains of the large subunit (LSU) rRNA gene and internal transcribed spacer (ITS) regions showed that these yeasts belong to the Bulleromyces clade and formed a cluster together with eleven undescribed Cryptococcus species. The novel species differed from its closest known species, Cryptococcus rajasthanensis, by 3.