Efficacy and Safety of Sevelamer Carbonate in Chinese Nondialysis Chronic Kidney Disease Patients with Hyperphosphatemia: A Randomized, Double-Blind, Parallel-Group Study.

Introduction: Previous studies suggested that sevelamer carbonate is well tolerated with a favorable efficacy and safety profile in both dialysis and nondialysis patients in Europe; however, the efficacy remains controversial, and few studies have examined sevelamer carbonate therapy in other ethnic nondialysis CKD patients. This study assessed the efficacy and safety of sevelamer carbonate in Chinese nondialysis CKD patients with hyperphosphatemia.

Methods: The multicenter, randomized, double-blind, parallel-group, placebo-controlled, and phase 3 clinical trial enrolled 202 Chinese nondialysis CKD patients with serum phosphorus ≥1.

2,2'-((1R,3R,4S)-4-methyl-4-vinylcyclohexane-1,3-diyl) bis(prop-2-en-1-amine), a bisamino derivative of β-Elemene, inhibits glioblastoma growth through downregulation of YAP signaling.

β-Elemene, a compound extracted from Chinese herb , has been demonstrated with antitumor effects in various cancers, including glioblastoma (GBM), a primary brain tumor with high morbidity and mortality. In this study, we reported a bisamino derivative of β-Elemene, 2, 2'-((1R, 3R, 4S)-4-methyl-4-vinylcyclohexane-1, 3-diyl) bis(prop-2-en-1-amine) (compound 1), displayed a better anti-GBM effect than β-Elemene with lower concentration. GBM cell lines (C6 and U87) were treated with compound 1 and subsequently analyzed by several assays.

Evaluation of the effects of standard rescue procedure on severe trauma treatment in china.

Background: This study aimed to evaluate the effects of standard rescue procedure (SRP) in improving severe trauma treatments in China.

Methods: This study was conducted in 12 hospitals located in geographically and industrially different cities in China. A standard procedure on severe trauma rescue was established as a general rule for staff training and patient treatment.

[A meta-analysis of bone morphogenetic protein for the treatment of open tibial fractures].

Objective: To systematically assess the clinical efficacy of bone morphogenetic proteins in the treatment of open tibial fractures.

Methods: Based on the principles and methods of Cochrane systematic reviews, the Cochrane Library, PubMed, EMBASE, Chinese Bio-medicine Database, China Journal Full-text Database, VIP database were searched from their establishment to April 2012 in whatever language. Related journals were handsearched as well.

[Pulsed electromagnetic field therapy for the treatment of knee osteoarthritis: a systematic review].

Objective: To evaluate the clinical effectiveness of pulsed electromagnetic field therapy in the treatment of knee osteoarthritis.

Methods: Based on the principles and methods of Cochrane systematic reviews, the authors searched the Cochrane Library (2012, 2 issue), PubMed (1966 to February, 2012), EMBASE (1974 to February, 2012), Chinese Biomedicine Database (1978 to February, 2012), China Journal Full-text Database (1979 to February, 2012), VIP database (1989 to February, 2012), as well as search engine Google Scholar. Randomized controlled trials (RCTs) of pulsed electromagnetic field therapy to treat knee osteoarthritis were included.

[Effect of autologous bone marrow stem cell transplantation on renal function following renal ischemic-reperfusion in rabbits].

Objective: To observe the effect of autologous bone marrow stem cell (BMSC) transplantation via the renal artery on renal function recovery following renal ischemic-reperfusion (I/R) injury in rabbits.

Methods: BMSCs were collected and isolated from rabbits. Twenty-eight rabbits were subjected to renal pedicle clamping for 105 min and randomized subsequently into transplantation group and control group.