De novo RNA sequencing and analysis reveal the putative genes involved in diterpenoid biosynthesis in roots.

Unlabelled: In this study, the putative genes involved in diterpenoid alkaloids biosynthesis in roots were revealed by transcriptome sequencing. 59.39 GB of clean bases and 119,660 unigenes were assembled, of which 69,978 unigenes (58.

Aggressive Local Treatment Improves Survival in Stage IV Breast Cancer With Synchronous Metastasis.

Introduction: To investigate the effect of local treatment strategy on survival outcome in stage IV breast cancer patients who received chemotherapy.

Methods: We identified stage IV breast cancers that presented with synchronous metastasis from the Surveillance, Epidemiology, and End Results database. Binomial logistic regression, Kaplan-Meier survival curves, propensity score matching (PSM), and multivariate Cox regression model were used for statistical analyses.

TRIM65 supports bladder urothelial carcinoma cell aggressiveness by promoting ANXA2 ubiquitination and degradation.

Clinically, most of human urothelial carcinoma of the bladder (UCB)-related deaths result from tumor metastasis, but the underlying molecular mechanisms are largely unknown. Recently, a growing number of tripartite motif (TRIM) family members have been suggested to be important regulators for tumorigenesis. However, the impact of most TRIM members on UCB pathogenesis is unclear.