Publications by authors named "Li-Ye Xie"
Background: Angiogenesis plays a pivotal role in colorectal cancer (CRC), yet its underlying mechanisms demand further exploration. This study aimed to elucidate the significance of angiogenesis-related genes (ARGs) in CRC through comprehensive multi-omics analysis.
Methods: CRC patients were categorized according to ARGs expression to form angiogenesis-related clusters (ARCs).
Oxaliplatin resistance poses a significant challenge in colorectal cancer (CRC) therapy, necessitating further investigation into the underlying molecular mechanisms. This study aimed to elucidate the regulatory role of SNHG4 in oxaliplatin resistance and ferroptosis in CRC. Our findings revealed that treatment with oxaliplatin led to downregulation of SNHG4 expression in CRC cells, while resistant CRC cells exhibited higher levels of SNHG4 compared to parental cells.
View Article and Find Full Text PDFArticle Synopsis
- * Five miRNAs were found to have altered expression in CRC tissues, with two being upregulated (miR-595 and miR-1237) and three downregulated (miR-126, miR-139, and miR-143).
- * While these miRNAs were linked to CRC pathogenesis, they were not correlated with cancer stage, and using a combination of them improved diagnostic accuracy for CRC compared to using a single miRNA.
The -acetyltransferase 1 () gene is downregulated in several cancers and associated with patient survival. In this study, we sought to examine the prognostic value and clinical significance of methylation in colon adenocarcinoma (COAD). Data relating to mRNA expression and methylation and clinicopathological features of COAD were extracted from the database of The Cancer Genome Atlas.
View Article and Find Full Text PDF