Publications by authors named "Li-Ye Shen"
Recent studies have showed that thrombosis is closely related to leucocytes involved in immunity. Interfering with the binding of leukocyte integrin Mac-1 and platelet GPIbα can inhibit thrombosis without affecting physiological coagulation. Mac-1-GPIbα is proposed as a potential safety target for antithrombotic agents.
View Article and Find Full Text PDFArticle Synopsis
- Oxidative stress is linked to chronic diseases and has been established in overt hypothyroidism, but its role in subclinical hypothyroidism (SCH) was the focus of this study to determine lipid and protein oxidation levels.
- The study involved 467 male adults with SCH and 190 euthyroid controls, measuring various health indicators including plasma lipids and markers of oxidative stress.
- Findings revealed higher levels of malondialdehyde (MDA) in SCH patients compared to controls, indicating increased oxidative stress, while no association was found between MDA and thyroid hormone levels, suggesting the need for oxidative stress reduction in SCH patients.
Background: Dityrosine, the modification of tyrosine residues, may contribute to metabolic disorders. This study was undertaken to investigate plasma dityrosine concentrations in patients with hyperlipidemia and to examine the correlation between dityrosine and lipid profiles.
Methods: Fluorescence spectrophotometry was used to measure dityrosine in the plasma of healthy subjects (n = 203) and dyslipidemic subjects, which included patients with mild hyperlipidemia (n = 246) and hyperlipidemia (n = 179).
Background: Metabolic Syndrome (MS), a known risk factor for Cardiovascular Disease (CVD) and type II diabetes is an emerging epidemic in China. Studies carried out on the general population indicate a varied clustering of cardiovascular risks in many parts of the country. However, there is limited data on its prevalence in the working population.
View Article and Find Full Text PDF