Marcks overexpression in retinal ganglion cells promotes optic nerve regeneration.

Regeneration of injured central nervous system (CNS) axons is highly restricted, leading to permanent neurological deficits. The myristoylated alanine-rich C-kinase substrate (MARCKS) is a membrane-associated protein kinase C (PKC) substrate ubiquitously expressed in eukaryotic cells, plays critical roles in development, brain plasticity, and tissues regeneration. However, little is known about the role of Marcks in CNS axon regeneration.

Evaluation of the Growth, Sporulation, Fungicide Efficacy, and Host Range of .

was primarily identified based on the characteristics of its conidia and several sequences. The fungus causes severe leaf spot disease on hairy vetch ( var. ) in Yunnan Province in China.

Germination and Invasion of on Roots of a Susceptible and a Resistant Alfalfa Cultivar ().

Alfalfa Paraphoma root rot (APRR) () is a recently described alfalfa disease widely distributed in China, first reported in 2020. So far, the resistance levels of 30 alfalfa cultivars to APRR have been characterized; however, the resistance mechanisms among these cultivars remain unknown. In the present study, the alfalfa resistance mechanisms against APRR were investigated by studying the difference of infecting susceptible (Gibraltar) and resistant (Magnum II) alfalfa cultivars under the light microscope and scanning electronic microscope.

Alternaria gansuense, a Plant Systematic Fungal Pathogen Producing Swainsonine in Vivo and in Vitro.

Astragalus adsurgens (A. adsurgens), which is considered a forage in China, grows widely in Eurasia and North America. However, Alternaria gansuense (A.

-A New Etiological Anthracnose Agent of Sword Bean () in Southwestern China.

Anthracnose is a disease caused by species. They are well known as major plant pathogens, and a black stem disease, specifically caused by and primarily infecting sword bean (), was observed in the Yunnan province, China. To aid disease management and to determine pathogenic characteristics, the species causing the leaf spot disease of hairy vetch was verified as .

The Characterization and the Biological Activity of Phytotoxin Produced by .

is a new pathogen that causes alfalfa paraphoma root rot (APRR), leading to alfalfa production losses. The resistance levels of 30 alfalfa cultivars to APRR have already been characterized. However, the pathogenic mechanism of is still unclear.

Effects of timothy Cladosporium eyespot on photosynthesis and biomass.

Timothy is a forage mainly grown in Min County, Gansu Province, China. In 2021, a leaf spot disease outbreak on timothy grass occurred in Min County, adversely affecting its growth and productivity. Therefore, this study investigated the leaf spot disease incidence in Min County, morphologically and molecularly characterized the disease-causing pathogen, and assessed its effects on the growth, photosynthesis, and biomass of timothy seedlings re-inoculated with the isolated pathogen.

First Report of Leaf Spot Caused by Ramularia sphaeroidea on Vicia villosa var. glabrescens in China.

Hairy vetch is widely grown in southwestern China for green manure and forage. In December 2019, a leaf disease occurred on 80% plants of in an eight-hectare field in Qujing(N 25°28'12″, E 103°36'22″), Yunnan Province, China. The disease leaves had irregular, brown to dark brown leaf spots with white mold.

First report of alfalfa leaf spot caused by Leptosphaerulina australis in China.

A disease was observed on alfalfa cultivar WL168 characterized by white to brown leaf spots of regular to round shapes, in Aluhorqin County, Inner Mongolia, China (120°13'23″ to 120°29'14″ E, 43°27'52″to 43°35'16″ N, 281.71m to360.13 m Altitude) during 2019 to 2020.

mTOR/NF-κB signaling pathway protects hippocampal neurons from injury induced by intermittent hypoxia in rats.

Objective: To expound the roles of mTOR and NF-kB signaling pathway in intermittent hypoxia (IH)-induced damage of hippocampal neurons.

Methods: For rat experiments, mTOR inhibitor (Rapamycin, Rapa) and NF-κB signaling inhibitor (ammonium pyrrolidine dithiocarbamate, PDTC) were applied to inhibit mTOR and NF-κB signaling, respectively. For neuron experiments, hippocampal neurons from rat were successfully cultured.

Identification, Characterization, Pathogenicity, and Distribution of in Alfalfa Plants in China.

Verticillium wilt caused by results in severe production losses in alfalfa crops and is a Class A quarantined disease in China. During 2015 to 2017, 365 alfalfa fields from 21 locations in six provinces were surveyed, and 45 fields from three closely located sites in Gansu, China were found to have alfalfa plants with symptoms typical of Verticillium wilt, with disease incidence of 12.6 to 53.

[Combined Process of DNBF-O-GAC for Nitrogen and Phosphorus and Metabolite Advanced Removal].

To improve the quality of the tailings water from a wastewater treatment plant (WWTP), a denitrification biofilter (DNBF) with a composite filler composed of a new slow-release organic-carbon source (SOC-F), sponge iron, and activated carbon was tested. Studies were conducted in the combined process of DNBF-O-GAC to explore the efficiency of the advanced removal of nitrogen, phosphorus, and microbial metabolite by using synthetic effluent made from running water and chemicals. Corresponding comparative studies were conducted by using the secondary effluent from the WWTP.

[Preparation and Phosphorus Removal Mechanism of Highly Efficient Phosphorus Adsorbent Mg/Al-LDO].

Aiming at the problem of phosphorus removal in water, Mg/Al-layered double hydroxides (Mg/Al-LDHs) were synthesized via optimized constant pH co-precipitation method, and highly efficient phosphorus adsorbent Mg/Al-layered double oxide(Mg/Al-LDO) was obtained when it was calcined at high temperature. Based on the adsorption characteristics of phosphorus removal, the study combined Zeta potential, X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) to analyze the changes of isoelectric point, crystal structure and functional group before and after adsorption. In addition, Mg/Al-LDO of phosphorus adsorption mechanism was discussed.

MicroRNA-133a suppresses the proliferation, migration, and invasion of laryngeal carcinoma cells by targeting CD47.

The study aims to investigate the possible mechanisms of microRNA-133a (miR-133a) targeting CD47 on cell proliferation, apoptosis, migration, and invasion in laryngeal carcinoma. Forty-two laryngeal carcinoma tissue specimens confirmed by pathological examination from laryngeal carcinoma patients as the case group were collected, and 20 chronic laryngitis tissues were gathered as the control group. The human laryngeal carcinoma cell line Hep-2 was marked as the miR-133a mimic, negative control (NC), miR-133a inhibitor, CD47-siRNA, miR-133a inhibitor + CD47-siRNA, and Mock groups.

[Feasibility of 3BER-S Process for the Deep Denitrification in Synch with the Removal of PAEs from Reclaimed Water].

In order to investigate the feasibility of deep denitrification and simultaneous removing phthalate esters (PAEs) in the process of reclaimed water treatment uses three-dimensional biofilm-electrode reactor coupled with sulfur autotrophic deep denitrification technology (3BER-S), the technological characteristics and mechanisms were analyzed based on determining the static adsorption capacity of biofilm cultured active carbon fillers in 3BER-S reactor together with the operation results of dynamic denitrification and simultaneous PAEs removing. The results showed that the average adsorption rates of DBP, DEHP were 85.84% and 97.

Enhanced anti-tumor activity of trichosanthin after combination with a human-derived cell-penetrating peptide, and a possible mechanism of activity.

Trichosanthin (TCS), a type I ribosome-inactivating protein (RIP-I) and renowned Chinese traditional medicine, displays a broad spectrum of biological and pharmacological properties. Particularly, its anti-tumor activity has received a great deal of attention. However, the cellular mechanism for TCS uptake varies with different tumor cell lines, leading to discrepancies in its reported ability to penetrate cells.

Cardiac structural and functional changes in old elderly patients with obstructive sleep apnoea-hypopnoea syndrome.

Objective: To investigate cardiac structural changes in elderly patients with obstructive sleep apnoea-hypopnoea syndrome (OSAHS) and the impact on left ventricular systolic and diastolic function.

Methods: The study enrolled elderly patients with OSAHS and age-matched healthy control subjects. Cardiac structure, left ventricular diastolic function and left ventricular systolic function were measured using a Doppler ultrasound scanner and compared between the two groups.

[Effects of electromagnetic radiation on health and immune function of operators].

Objective: To investigate the effects of electromagnetic radiation on the physiological indices and immune function of operators.

Methods: The general conditions and electromagnetic radiation awareness rate of 205 operators under electromagnetic radiation were evaluated using a self-designed questionnaire. Physical examination, electrocardiography, and routine urine test were performed in these operators.

Nutritional study on Embellisia astragali, a fungal pathogen of milk vetch (Astragalus adsurgens).

Embellisia astragali is a strong, virulent pathogen that develops within milk vetch (Astragalus adsurgens). In order to determine nutrient requirements, the fungus was cultured on 9 carbon sources, 9 nitrogen sources, and 13 growth media in the dark at 25 degrees C. Growth rates and sporulation capacity were measured after 4 and 12 weeks.

Adsorption removal of phosphate from aqueous solution by active red mud.

Red mud is the waste of alumina industry and has high TiO2 and Fe2O3 content which are active components for the adsorption of anion pollutants. In this study, the uptake of phosphate by red mud activated by heat treatment and acid-heat treatment was investigated. The factors influencing the adsorption were also investigated.

Symptomology and etiology of a new disease, yellow stunt, and root rot of standing milkvetch caused by Embellisia sp. in Northern China.

An Embellisia sp. has been established as the cause of a new disease of the herbaceous perennial forage legume, 'standing milkvetch' (Astragalus adsurgens Pall.) in Northern China, which severely reduces plant density and degrades A.

[Breakage and regrowth of flocs coagulation with polyaluminum chloride (PACl)].

The conventional jar test and the monitoring technique of floc size in line were employed to investigate the breakage and regrowth of the flocs formed by PACl. It was found that the breakage and regrowth of flocs varied with coagulation zones. The flocs formed in stabilization zone were of high strength and difficult to break, and could regrow better after broken, with the recovery factor of up to 259%.

Performance of a novel vertical-flow settler: a comparative study.

By increasing particle concentration and G value (root-mean-square velocity gradient) to enhance flocculation, a novel vertical-flow settler was designed to increase sedimentation effectiveness, and to simultaneously improve operational stabilization. Due to the gradual decrease in upward flow-rate of raw water, a flocs blanket would form and suspend in the middle section of the settler, not at the bottom as in a conventional clarifier. Enough large flocs, resulted from flocculation or filtration, would continuously settle out of the flocs blanket, and simultaneously, the flocs in raw water or those forming above the blanket would ceaselessly enter the flocs blanket.

[The role of adhesion molecules in the pathogenic mechanisms of hypertension in obstructive sleep apnea-hypopnea syndrome].

Objective: To explore the role of adhesion molecules in the pathogenesis of hypertension in obstructive sleep apnea-hypopnea syndrome (OSAHS).

Methods: The levels of serum soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and L-selectin in 30 OSAHS patients accompanied by hypertension, 30 normotensive OSAHS patients and 30 healthy controls were measured by enzyme-linked immunosorbent assay (ELISA) method. The relationship of the concentration of ICAM-1, VCAM-1 and L-selectin with the polysomnogram (PSG) parameters was analyzed.