Publications by authors named "Li-Ya Ai"
Background: The self-repair ability after meniscal tears is poor, leading to the development of posttraumatic osteoarthritis. Promoting the repair of meniscal injuries remains a great challenge, especially in the avascular region.
Hypothesis: Local delivery of skeletal stem cell (SSC)-derived exosomes (SSC-Exos) would promote meniscal healing and prevent secondary osteoarthritis progression.
Meniscus heterogeneity and 3D-printed strategies for engineering anisotropic meniscus.
Int J Bioprint
February 2023
The meniscus is a fibrocartilaginous tissue of the knee joint that plays an important role in load transmission, shock absorption, joint stability maintenance, and contact stress reduction. Mild meniscal injuries can be treated with simple sutures, whereas severe injuries inevitably require meniscectomy. Meniscectomy destroys the mechanical microenvironment of the knee joint, leading to cartilage degeneration and osteoarthritis.
View Article and Find Full Text PDFOsteoarthritis (OA) is a progressive joint disease characterized by inflammation and cartilage destruction, and its progression is closely related to imbalances in the M1/M2 synovial macrophages. A two-pronged strategy for the regulation of intracellular/extracellular nitric oxide (NO) and hydrogen protons for reprogramming M1/M2 synovial macrophages is proposed. The combination of carbonic anhydrase IX (CA9) siRNA and NO scavenger in "two-in-one" nanocarriers (NAHA-CaP/siRNA nanoparticles) is developed for progressive OA therapy by scavenging NO and inhibiting CA9 expression in synovial macrophages.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the role of long non-coding RNAs (lncRNAs) in the aging process of the meniscus, identifying 1608 differentially expressed (DE) lncRNAs and 1809 DE mRNAs through microarray analysis and confirming results with qRT-PCR.
- - Key findings reveal that DE mRNAs are involved in critical signaling pathways (like TGF-beta and Wnt), with specific upregulations of TNFRSF11B and BMP2 in the aging group.
- - Four lncRNAs (AC124312.5, HCG11, POC1B-AS1, and AP001011.1) were linked to meniscus degradation, with functional analyses suggesting they interact with various
Objective: To observe the effect of Mongolian medicine three-acupoints balance needling on the expression of p11/tPA/BDNF pathway and miRNA-16 in the hippocampus and middle raphe nucleus (MRN) in chronic stress depression model rats, so as to explore its mechanisms underlying improvement of depression.
Methods: Male SD rats were randomly divided into blank control, model, medication and Mongolian medicine acupuncture (acupuncture) groups, with 12 rats in each group. The depression model was established by using chronic unpredictable mild stress method.