Efficacy and Safety of Pioglitazone/Metformin Fixed-Dose Combination Versus Uptitrated Metformin in Patients with Type 2 Diabetes without Adequate Glycemic Control: A Randomized Clinical Trial.

Introduction: We aim to evaluate the efficacy and safety of pioglitazone/metformin fixed-dose combination (FDC) versus uptitrated metformin in patients with type 2 diabetes mellitus (T2DM) without adequate glycemic control.

Methods: A total of 304 patients were recruited from 15 hospitals in China and randomly assigned (1:1) to the test group (pioglitazone/metformin FDC, 15/500 mg) or the control group (uptitrated metformin, 2000-2500 mg/day). The primary endpoint was the proportion of patients with glycated hemoglobin A1c (HbA1c) ≤ 6.

Destruction mechanism of anterior cervical discectomy and fusion in frontal impact.

The aim of this study was to quantitatively study the effect of anterior cervical discectomy and fusion (ACDF) on the risk of spinal injury under frontal impact. A head-neck finite element model incorporating active neck muscles and soft tissues was developed and validated. Based on the intact head-neck model, three ACDF models (single-level, two-level and three-level) were used to analyze the frontal impact responses of the head-neck.

A Biomechanical Comparison of 2 Different Topping-off Devices and Their Influence on the Sacroiliac Joint Following Lumbosacral Fusion Surgery.

Objective: Interspinous spacer (ISS)-based and pedicle screw-rod dynamic fixator (PDF)-based topping-off devices have been applied in lumbar/lumbosacral fusion surgeries for preventing the development of proximal adjacent segment degeneration. However, little attention has been paid to sacroiliac joint (SIJ), which belongs to the adjacent joints. Accordingly, the objective of this study was to compare how these 2 topping-off devices affect the SIJ biomechanics.

Maturity-onset diabetes of the young type 10 caused by an Ala2Thr mutation of : A case report.

Background: Maturity-onset diabetes of the young 10 caused by the c.4G>A (p.Ala2Thr) mutation is extremely rare, with only two reported studies to date.

Renal elasticity and perfusion changes on ultrasonography in an early-stage diabetic rat model.

Background: Renal hemodynamic changes in early diabetes occur before the onset of significant structural abnormalities or clinical manifestations, and timely detection of these changes has clinical significance. This study aimed to evaluate renal elasticity and perfusion changes in an early-stage diabetic rat model by shear wave elastography (SWE) and contrast-enhanced ultrasound (CEUS), and to explore the potential correlations between renal elasticity and perfusion parameters.

Methods: A total of 18 male Sprague-Dawley rats were randomly divided into three groups: a control group (group 1, n=6), a diabetic group (group 2, n=6), and a diabetic group receiving drug therapy (group 3, n=6).

The effects of topping-off instrumentation on biomechanics of sacroiliac joint after lumbosacral fusion.

Background: Lumbar/lumbosacral fusion supplemented with topping-off devices has been proposed with the aim of avoiding adjacent segment degeneration proximal to the fusion construct. However, it remains unclear how the biomechanics of the sacroiliac joint (SIJ) are altered after topping-off surgery. The objective of this study was to investigate the biomechanical effects of topping-off instrumentation on SIJ after lumbosacral fusion.

Prediction of the biomechanical behaviour of the lumbar spine under multi-axis whole-body vibration using a whole-body finite element model.

Low back pain has been reported to have a high prevalence among occupational drivers. Whole-body vibration during the driving environment has been found to be a possible factor leading to low back pain. Vibration loads might lead to degeneration and herniation of the intervertebral disc, which would increase incidence of low back problems among drivers.

Efficacy of Exenatide Administered Twice Daily in Body Mass Index Reduction in Patients with Type 2 Diabetes Mellitus.

Background: Exenatide is a glucagon-like peptide-1 receptor agonist that can reduce body weight. This study aimed to determine the efficacy of exenatide on body mass index (BMI) reduction in patients with type 2 diabetes mellitus (T2DM) with differing baseline body weight, blood glucose, and atherosclerotic status and to determine if there is a correlation between BMI reduction and cardiometabolic indices in these patients.

Methods: This retrospective cohort study used data from our randomized controlled trial.

Paternal sleep deprivation induces metabolic perturbations in male offspring via altered LRP5 DNA methylation of pancreatic islets.

Diabetes and metabolic perturbation are global health challenges. Sleep insufficiency may trigger metabolic dysregulation leading to diabetes. However, the intergenerational transmission of this environmental information is not clearly understood.

Biomechanical Evaluation of Rigid Interspinous Process Fixation Combined With Lumbar Interbody Fusion Using Hybrid Testing Protocol.

Rigid interspinous process fixation (RIPF) has been recently discussed as an alternative to pedicle screw fixation (PSF) for reducing trauma in lumbar interbody fusion (LIF) surgery. This study aimed to investigate biomechanics of the lumbar spine with RIPF, and also to compare biomechanical differences between two postoperative stages (before and after bony fusion). Based on an intact finite-element model of lumbosacral spine, the models of single-level LIF with RIPF or conventional PSF were developed and were computed for biomechanical responses to the moments of four physiological motions using hybrid testing protocol.

Biomechanical responses of the human lumbar spine to vertical whole-body vibration in normal and osteoporotic conditions.

Background: The prevalence of osteoporosis is continuing to escalate with an aging population. However, it remains unclear how biomechanical behavior of the lumbar spine is affected by osteoporosis under whole-body vibration, which is considered a significant risk factor for degenerative spinal disease and is typically present when driving a car. Accordingly, the objective of this study was to compare the spine biomechanical responses to vertical whole-body vibration between normal and osteoporotic conditions.

Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts' Committee Of National Society Of Cardiometabolic Medicine.

Low-density lipoprotein cholesterol (LDL-C) has been considered as the primary target for the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). However, there are still residual cardiovascular risks in some patients even if LDL-C achieves the target level. Emerging evidence suggestes that elevated triglyceride (TG) level or triglyceride-rich lipoprotein (TRL) cholesterol (TRL-C) is one of the important components of the residual cardiovascular risks.

Effect of different fixation methods on biomechanical property of cervical vertebral body replacement and fusion.

Background: The main purpose of this study was to examine the effect of different fixation methods (anterior fixation, self-stabilizing fixation and anterior-posterior fixation) on biomechanical property of vertebral body replacement and fusion.

Methods: Three finite element models of cervical vertebral body replacement and fusion were established. The implanted models included artificial vertebral body and fixation system, and the loads imposed on the models included 75 N compression load and 1 Nm moment load.

Effect of whole-body vibration at different frequencies on the lumbar spine: A finite element study based on a whole human body model.

Many previous studies have found that occupational drivers commonly suffered from low back pain, and low back pain and degeneration of the intervertebral disc might be associated with vibration conditions. However, the biomechanical mechanisms of whole-body vibration that caused pain and injury were not clear. In this study, a validated whole human body finite element model was used, and vibration loads at frequencies of 3, 5, 7 and 9 Hz were loaded to evaluate the frequency effects on the spine.

Strip SAR image simulation of a composite vehicle-ground model.

In this paper, the strip synthetic aperture radar (SAR) image of a composite vehicle-ground model is simulated by combining the electromagnetic scattering algorithm and radar imaging algorithm. A linear frequency modulated wave is incident on the composite model, which is partitioned into a mass of triangular patches. In the "stop-and-go" radar mode, for each patch, the amplitude of scattered echo in the frequency domain is solved by a hybrid method of physical optics (PO)-shooting and bouncing ray (SBR)-physical theory of diffraction (PTD).

Topology optimization and dynamic characteristic evaluation of W-shaped interspinous process device.

For reducing the adjacent segment degeneration of the lumbar spine, the interspinous process device as a kind of flexible non-fusion device was designed to overcome the deficiencies associated with rigid fusion devices. However, it was not clear how the interspinous process device influenced the human spine system, especially the lumbar spine under a vibration environment. This study was designed to evaluate the effect of StenoFix under the vibration condition and also to optimize the structure of the device to obtain better biomechanical performance.

Biomechanical analysis of lumbar nonfusion dynamic stabilization using a pedicle screw-based dynamic stabilizer or an interspinous process spacer.

This study aimed to investigate and compare the effects of two widely used nonfusion posterior dynamic stabilization (NPDS) devices, pedicle screw-based dynamic stabilizer (PSDS) and interspinous process spacer (IPS), on biomechanics of the implanted lumbar spine under static and vibration loadings. The finite element model of healthy human lumbosacral segment was modified to incorporate NPDS device insertion at L4-L5 segment. Bioflex and DIAM were used as PSDS-based and IPS-based NPDS devices, respectively.

Biomechanical role of cement augmentation in the vibration characteristics of the osteoporotic lumbar spine after lumbar interbody fusion.

Under whole body vibration, how the cement augmentation affects the vibration characteristic of the osteoporotic fusion lumbar spine, complications, and fusion outcomes is unclear. A L1-L5 lumbar spine finite element model was developed to simulate a transforaminal lumbar interbody fusion (TLIF) model with bilateral pedicle screws at L4-L5 level, a polymethylmethacrylate (PMMA) cement-augmented TLIF model (TLIF-PMMA) and an osteoporotic TLIF model. A 40 N sinusoidal vertical load at 5 Hz and a 400 N preload were utilized to simulate a vertical vibration of the human body and the physiological compression caused by muscle contraction and the weight of human body.

Development and Validation of a Whole Human Body Finite Element Model with Detailed Lumbar Spine.

Objective: Investigations showed that low back pain of occupational drivers might be closely related to the whole-body vibration. Restricted by ethical concerns, the finite element method had become a viable alternative to invasive human experiments. Many mechanical behaviors of the human spine inside of the human body were unclear; therefore, a human whole-body finite element model might be required to better understand the lumbar behavior under whole-body vibration.

Biomechanical investigation of topping-off technique using an interspinous process device following lumbar interbody fusion under vibration loading.

Topping-off technique has been proposed to prevent adjacent-segment degeneration/disease following spine fusion surgery. Nevertheless, few studies have investigated biomechanics of the fusion surgery with topping-off device under whole-body vibration (WBV). This biomechanical study aimed to investigate the vibration characteristics of human lumbar spine after topping-off surgery, and also to evaluate the effect of bony fusion on spine biomechanics.

Fuzzy Logic Analysis for Key Factors for Customer Loyalty in E-Shopping Environment.

Due to subjective evaluation and qualitative characteristics, the assessment processes of loyalty often cannot use the crisp value to express the final value. That makes the evaluation of online store performance usually filled with uncertainty and ambiguity. The loyalty assessment of electronic shopping is complex, and online stores' strategy and production control problems are frequently accompanied by uncertain conditions.

Frequency controlled beam scanning characteristic realized using a compact slow wave transmission line.

To simplify the design of a beam scanning device, we present a simple and compact structure to realize the frequency scanning characteristic based on a hybrid waveguide consisting of a spoof surface plasmon polariton (SSPP) transmission line and half-mode substrate integrated waveguide (HMSIW). Additionally, the radiation characteristic is implemented using periodically modulated slots. The scanning angle range covers backward to forward directions without an open stop band at the broadside.

Equity Structure, Strategic Investment Psychology, and Performance in China's Green Economy Context.

This study empirically tests the impacts of equity structure on strategic investment psychology in green affairs in R&D vs. Marketing dimensions and company performance. Based on data from Chinese high-tech industry listed companies, the empirical results show that: (1) the largest shareholder's shareholding ratio has a positive effect on marketing investment psychology and a negative impact on R&D investment psychology, (2) other large shareholders' shareholding ratio are positive related to R&D investment psychology; (3) R&D investment psychology has a negative effect and marketing investment psychology has a positive influence on the current performance; (4) equity counterbalance is positive related to R&D investment psychology and has a negative effect on the current performance.

Sitagliptin attenuates endothelial dysfunction independent of its blood glucose controlling effect.

Although the contributions of sitagliptin to endothelial dysfunction in diabetes mellitus were previously reported, the mechanisms still undefined. Autophagy plays an important role in the development of diabetes mellitus, but its role in diabetic macrovascular complications is unclear. This study aims to observe the effect of sitagliptin on macrovascular endothelium in diabetes and explore the role of autophagy in this process.