Role of NLRP3 and NLRP1 inflammasomes signaling pathways in pathogenesis of rheumatoid arthritis.

Objectives: To investigate the role of NLRP3 and NLRP1 inflammasomes signaling pathways in rheumatoid arthritis (RA).

Methods: A total of 36 patients with RA were selected, peripheral blood mononuclear cell (PBMC) and granulocyte were separated from venous blood. RT-qPCR method was used to detect the expression level and diversity of NLRP3 and NLRP1 in PBMC and granulocyte mRNA in patients with RA, and detect the mRNA expression of downstream factor IL-1α.

Lung injury following lower extremity blast trauma in rats.

Background: Lower extremity blast trauma is a common injury during armed conflict and after terrorist attacks with a high mortality, which is likely associated with distant vital organ injury. The current study aimed to investigate the underlying mechanisms of remote lung injury after blast lower extremity trauma.

Methods: Sprague-Dawley rats were randomly divided into two groups: sham and blast.

[The clinical significance of serum leptin level in IgA nephropathy patients].

Aim: To explore the change of serum leptin level and its clinical significance in the patients with IgA nephropathy.

Methods: A total of 40 IgA nephropathy patients were divided into group A (unnecessary for hemodialysis regimen) and B group (requisite for hemodialysis regimen). Other 20 healthy people for health examination homeochronously in our hospital were used as the control group (C group).

Low- and high-dose hydrogen peroxide regulation of transcription factor NF-E2-related factor 2.

Background: Reactive oxygen species (ROS) may play both physiological and pathophysiological roles. Transcription factor NF-E2-related factor 2 (Nrf2) regulates antioxidant response element (ARE)-mediated genes expression and coordinates induction of chemoprotective proteins in response to physical and chemical stresses. The exact role of Nrf2 in cellular responses to different levels of oxidative stresses remains unknown.