Publications by authors named "Li-Ting Lin"

Renewable feedstocks are sought for clean technology applications, including energy storage applications. In this study, LignoForce™ lignin, a biobased aromatic polymer commercially isolated from wood, was fractioned into two parts using acetone, and the resulting lignin fractions had distinct thermo-rheological behavior. These two fractionated lignins were combined in various ratios and transformed into nanofibers by electrospinning.

View Article and Find Full Text PDF
Article Synopsis
  • Alzheimer's disease (AD) is a progressive brain disorder that affects memory, and the role of patchouli alcohol (PA) in treating it is not fully understood.
  • This study used a mouse model of AD, induced by amyloid-beta (Aβ) and stimulated by lipopolysaccharide (LPS), to investigate PA's therapeutic effects on cognitive function and its mechanism in enhancing autophagy and reducing neuroinflammation.
  • Findings showed that PA improved memory and cognitive impairments in mice and reduced microglial activation, likely by influencing the AMPK/mTOR signaling pathway to decrease neuroinflammation and enhance autophagy.
View Article and Find Full Text PDF

Avian infectious bronchitis virus (IBV) still causes serious economic losses in the poultry industry. Currently, there are multiple prevalent genotypes and serotypes of IBVs. It is imperative to develop a new diagnosis method that is fast, sensitive, specific, simple, and broad-spectrum.

View Article and Find Full Text PDF

The neurohormone melatonin (MLT) demonstrates promising potential in ameliorating neuropathic pain induced by paclitaxel (PTX) chemotherapy. However, little is known about its protective effect on dorsal root ganglion (DRG) neurons in neuropathic pain resulting from the chemotherapeutic drug PTX. Here, PTX-treated rats revealed that intrathecal administration of MLT dose-dependently elevated hind paw withdrawal thresholds and latency, indicating that MLT significantly reversed PTX-induced neuropathic pain.

View Article and Find Full Text PDF

Background: The microtubule-stabilizing drug paclitaxel (PTX) is an important chemotherapeutic agent for cancer treatment and causes peripheral neuropathy as a common side effect that substantially impacts the functional status and quality of life of patients. The mechanistic role for NIMA-related kinase 2 (NEK2) in the progression of PTX-induced neuropathic pain has not been established.

Methods: Adult male Sprague-Dawley rats intraperitoneally received PTX to induce neuropathic pain.

View Article and Find Full Text PDF

Background: Hepatobiliary disease currently serves as an urgent health issue in public due to health-modulating factors such as extension of life expectancy, increasingly sedentary lifestyles and over-nutrition. A definite treatment remains lacking owing to different stages of the disease itself and its intricate pathogenesis. Traditional Chinese medicine (TCM) has been gradually popularized in clinic with the satisfactory efficacy and good safety.

View Article and Find Full Text PDF

Objective: Survival from out-of-hospital cardiac arrest (OHCA) often depends on the effective and immediate use of automated external defibrillators (AEDs). Given that there have been few studies about AED use in China, the purpose of this study is to investigate the knowledge and attitudes regarding AED use among the Chinese public, then provide an effective suggestion for AED education strategies and legislation.

Method: The online survey was conducted among Chinese participants of the First Aid eLearning courses in June 2020.

View Article and Find Full Text PDF

Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen hydrogels and poly(vinyl alcohol) PVA/Chitosan (PVA/CS) nanofibers. Based on time to degradation (21 days), nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002 (each at 50 mg/g).

View Article and Find Full Text PDF

Background: Infectious bronchitis virus (IBV) leads to huge economic losses in the poultry industry worldwide. The high levels of mutations of IBV render vaccines partially protective. Therefore, it is urgent to explore an effective antiviral drug or agent.

View Article and Find Full Text PDF

Methicillin-resistant Staphylococcus aureus (MRSA), a leading cause of infections in human being and is usually associated with a multidrug-resistant profile, represents a significant health threat and public burden globally. The limited options of effective antibiotics motivate the search for novel anti-MRSA agents. Aminoglycoside antibiotics have been extensively applied in the medical field due to their desirable broad-spectrum antibacterial activity, especially for systemic infections caused by Gram-negative organisms.

View Article and Find Full Text PDF

A novel avian infectious bronchitis virus (IBV) variant, designated as GX-NN160421, was isolated from vaccinated chicken in Guangxi, China, in 2016. Based on analysis of the S1 gene sequence, GX-NN160421 belonged to the New-type 1 (GVI-1) strain. More importantly, three consecutive nucleotides (AAC) deletions were found in the highly conserved structure gene N.

View Article and Find Full Text PDF

Aims: Chronic cerebral hypoperfusion (CCH) elicits inflammatory response, which contributes to the pathology of cognitive impairment. Several studies demonstrate that the alpha-7 nicotinic acetylcholine receptor (α7nAChR) can be a key component to modulate the inflammatory responses. We have reported previously that acupuncture attenuated cognitive deficits induced by CCH.

View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on a hybrid two-component system (TCS) that regulates swarming ability and biofilm formation in an opportunistic pathogen causing various infections.
  • Researchers determined the crystal structures of two key proteins, HptB and the receiver domain of HK PA1611, to investigate their interactions for transferring a phospho-ryl group.
  • The findings reveal unique structural features and interactions between these proteins that differ from other TCS complexes, enhancing our understanding of the TCS and potentially guiding new treatments for infections.
View Article and Find Full Text PDF

Background: It is widely accepted that inflammation may contribute to cognitive impairment in patients with vascular dementia (VD). Our prior clinical researches have reported that acupuncture can alleviate cognitive function in VD, but the underlying mechanisms are still unclear. The purpose of this research was to explore whether acupuncture alleviates cognitive impairment by suppressing the microRNA-93- (miR-93-) mediated Toll-like receptor (TLR) signaling pathway, which triggers inflammatory responses in the central nervous system.

View Article and Find Full Text PDF

A highly efficient approach of visible-light-driven radical difluoromethylation of isocyanides to access a wide variety of difluoromethylated phenanthridines and isoquinolines is herein described. Electrophilic -(difluoromethyl)diarylsulfonium salt proved to be a good difluoromethyl radical precursor under photoredox catalysis. A broad range of isocyanides were tolerated to furnish the corresponding difluoromethylated phenanthridines, isoquinolines, furo[3,2-]pyridine, and pyrido[3,4-]indole in moderate to excellent yields under mild conditions.

View Article and Find Full Text PDF

A facile and practical approach for the difluoromethylation of phenols and thiophenols was described. Making use of the recently developed bench-stable -(difluoromethyl)sulfonium salt as the difluorocarbene precursor, a wide variety of diversely functionalized phenols and thiophenols were readily converted to their corresponding aryl difluoromethyl ethers in good to excellent yields in the presence of lithium hydroxide. Chemoselectivity of various ,-nucleophiles toward difluorocarbene was systematically studied, suggesting the reactivity order ArS- > RS-, ArO- > ROH > RO-, ArSH, ArOH, RSH.

View Article and Find Full Text PDF

Bee venom is a very complex mixture of natural products extracted from honey bee which contains various pharmaceutical properties such as peptides, enzymes, biologically active amines and nonpeptide components. The use of bee venom into the specific points is so called bee venom therapy, which is widely used as a complementary and alternative therapy for 3000 years. A growing number of evidence has demonstrated the anti-inflammation, the anti-apoptosis, the anti-fibrosis and the anti-arthrosclerosis effects of bee venom therapy.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how mitochondrial dysfunction in the hippocampus, caused by oxidative stress, contributes to cognitive problems in vascular dementia (VD) and whether acupuncture can help.
  • Researchers created a VD model in rats using bilateral common carotid artery occlusion (BCCAO) and observed cognitive deficits along with impaired mitochondrial function and increased reactive oxygen species (ROS).
  • After two weeks of acupuncture treatment, the rats showed improved learning and memory, along with enhanced mitochondrial activity and reduced ROS, suggesting that acupuncture may help restore mitochondrial function and prevent cognitive decline in VD.
View Article and Find Full Text PDF

Emerging evidence suggests acupuncture could exert neuroprotection in the vascular dementia via anti-oxidative effects. However, the involvement of Nrf2, a master regulator of antioxidant defense, in acupuncture-induced neuroprotection in vascular dementia remains undetermined. The goal of our study was to investigate the contribution of Nrf2 in acupuncture and its effects on vascular dementia.

View Article and Find Full Text PDF
Article Synopsis
  • Acupoints are specific sites used in acupuncture, believed to have various therapeutic effects that need further understanding.
  • The review examines how stimulating acupoints can affect the body both locally and systemically, helping to maintain organ function and homeostasis.
  • More research is needed to clarify what defines an acupoint, and using new technologies in studies could lead to important discoveries.
View Article and Find Full Text PDF

Background: Decreased cognition is recognized as one of the most severe and consistent behavioral impairments in dementia. Experimental studies have reported that acupuncture may improve cognitive deficits, relieve vascular dementia (VD) symptoms, and increase cerebral perfusion and electrical activity.

Methods: Multi-infarction dementia was modeled in rats with 3% microemboli saline suspension.

View Article and Find Full Text PDF

Preimplantation genetic diagnosis (PGD) is employed increasingly to allow transfer of embryos to the uterus in assisted reproduction procedures. There are three stages of biopsy: polar bodies, one or two blastomeres from the cleavage-stage embryos, and trophectoderm cells ( approximately 5cells) from the blastocyst-stage embryos. Validation of polymerase chain reaction (PCR)-based assays are challenging because only limited genetic material can be obtained for PGD.

View Article and Find Full Text PDF

A strategy was developed using the OmniPlex technology of whole genome amplification for preimplantation genetic diagnosis (PGD) of single gene diseases and human leukocyte antigen (HLA) haplotypes. The amplified genomic DNA library was subsequently examined separately for mutation analysis with mini-sequence and for short tandem repeat (STR) markers within the HLA loci. To evaluate the reliability of the protocol prior to PGD, tests of 50 single lymphocytes revealed an amplification efficiency of 92-96% and allele drop-out (ADO) rate of 6-16%.

View Article and Find Full Text PDF

The objective of this study was to manufacture fire-retardant-treated low-formaldehyde-emission particleboard from recycled wood-waste particles using polymeric 4,4'-methylenediphenyl isocyanate (PMDI) and phenol-formaldehyde (PF) resins. The influence of the PMDI/PF ratio (ratio of particles sprayed with PMDI to particles sprayed with PF, w/w) after fire retardant treatment on formaldehyde emissions, mechanical properties, and surface fire resistant performance of the manufactured particleboard was investigated. The experimental results showed that the formaldehyde emissions linearly decreased with an increasing PMDI/PF ratio.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session4ihhrd3je1bvnb8rp3amfji0mdoionqj): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once