Publications by authors named "Li-Sha Bao"
Article Synopsis
- Urea cycle disorders (UCDs) are rare genetic conditions that lead to high ammonia levels in the body and vary in their severity, caused by deficiencies in key biomolecules of the urea cycle.
- A study analyzed five UCD cases using clinical, biochemical, and genetic assessments, identifying nine genetic variants, including three new ones linked to specific disorders like Argininosuccinic aciduria and Citrin deficiency.
- The research confirmed the pathogenicity of the identified genetic variants, broadening our understanding of UCD and aiding in genetic counseling for affected families.
Objective: To identify risk factors for minimally invasive surfactant administration (MISA) failure in the treatment of preterm infants with respiratory distress syndrome (RDS) and the influence of MISA failure on neonatal outcome.
Methods: A retrospective analysis was performed for the clinical data of 148 preterm infants with a gestational age of ≤32 weeks and a clinical diagnosis of RDS, who were admitted to the neonatal intensive care unit of eight tertiary hospitals in Beijing, Tianjin and Hebei Province from July 1, 2017 to December 31, 2018 and were treated with MISA (bovine pulmonary surfactant, PS). According to whether MISA failure (defined as the need for mechanical ventilation within 72 hours after MISA) was observed, the infants were divided into two groups: MISA failure group (n=16) and MISA success (n=132).