[Longitudinal evaluation of reparative cartilage after matrix-associated autologous chondrocyte implantation with delayed gadolinium-enhanced MRI of the cartilage].

Objective: To estimate zonal variation of GAG content in reparative cartilage after matrix associated autologous chondrocyte implantation (MACI) using delayed gadolinium-enhanced magnetic resonance imaging of the cartilage (dGEMRIC).

Methods: Seven patients (14 cartilage defects) undergoing MACI were recruited for examination with dGEMRIC at 3, 6, and 12 months after the procedure to calculate global and zonal longitudinal relaxivity (Δ R1) of the normal cartilage and reparative cartilage.

Results: The mean Δ R1 values of normal cartilage were significantly lower than those of reparative cartilage after MACI.