Pooled Analysis of Gastric Emptying in Patients With Obesity: Implications for Oral Absorption Projection.

Purpose: Gastric emptying time is one of limiting factors that determines the pharmacokinetic properties of drugs administered by mouth. Despite the high prevalence of obesity worldwide, modifications in gastric emptying time have not been systematically addressed in this set of patients. The current analysis aims to quantitatively address obesity-related changes in gastric emptying time of solids, semisolids, and liquids compared with lean individuals, highlighting the relevant pharmacokinetic implications of oral drug absorption in patients with obesity.

An Observational Study: Is -Acetylcysteine Helpful in Performance Improvement of Mycoplasma IST2 Testing through Sample Homogenization?

Background: Culture is still the gold standard for the detection of genital mycoplasma which could cause urogenital infections in humans. Mycoplasma IST2 is a commercial kit widely used for the detection of and species. Its accuracy was partially impaired because clinical specimens are usually mixed with purulent or transparent mucus.

Comparison of chemical constitution and bioactivity among different parts of Lonicera japonica Thunb.

Background: Lonicera japonica Thunb is a common herb in East Asia. The flower buds are usually regarded as the traditional medicinal part, while leaves and stems are considered less valuable and receive little attention. This study compared the chemical constituents and anti-inflammatory effects of the different tissues in L.

A new modified sesquiterpene glycoside from Cupressus chengiana.

A new sesquiterpene glycoside, cupressusoside (1), and five known compounds were isolated from the 70% aqueous ethanol extract of the branches and leaves of Cupressus chengiana. Their structures were elucidated by using spectroscopic methods. All the isolates expressed no remarkable cytotoxic activity against colon carcinoma (HCT-8) and breast cancer (MCF-7) cell lines, with IC50>40 mg/mL.