A Triple-Heterozygous β-Thalassemia Patient Demonstrated an Unusual Electrophoresis Pattern Due to a Novel β Mutation [an IVS-II-654 (C>T) mutation with a Hb Zürich-Langstrasse (: c.151A>T) mutation ].

β-Thalassemia (β-thal) is caused by mutations on the β-globin genes, causing reduced (β) or absent (β) synthesis of the β chains of hemoglobin (Hb). In this report, a 28-year-old male patient with anemia and jaundice, was diagnosed with triple-heterozygous β-thal [an IVS-II-654 (C>T) mutation, a Hb Zürich-Langstrasse (: c.151A>T) mutation and a Hb G-Siriraj (: c.

Peak urea level, leukocyte count and use of invasive ventilation as risk factors of mortality in acute pancreatitis: A retrospective study.

Background: Acute pancreatitis (AP) is associated with high complications. Early, reliable prediction of mortality may improve patient management.

Methods: We retrospectively reviewed medical records of 1,599 patients with AP treated at a single large hospital in southwest China.

A Phenotypically Unusual Hemoglobin H Disease Resulting from a Rare α-Globin Genotype (-/-α).

Hemoglobin H (Hb H) disease is usually characterized by the existence of Hb H, which influences the degree of functional anemia. We here report a patient with a rare Hb H disease genotype (-/-α), who was observed to paradoxically have no detectable Hb H fraction on electrophoresis. To date, the reason why the quantity of Hb H component and the clinical presentation in Hb H disease vary widely is still incompletely understood.

[Adjusting Platelet Counts for Platelet Aggregation Tests].

Objective: To explore a better method to adjust platelet counts for light transmission aggregometry (LTA).

Methods: Blood samples from 36 healthy participants aged from 18 to 50 yr. were collected.

[Effects of Danqi Capsule on Platelet Function in Healthy People].

Objectives: To study the effects of Danqi Capsule on platelet function in healthy people.

Methods: Sixteen healthy volunteer were divided into low dose (4 capsules/time, 3 times/d) and high dose group (6 capsules/time, 3 times/d), and received Danqi Capsule by orally administration for 2 weeks. The venous blood were collect at 3 time points: one week before taking Danqi Capsule (control), one week after taking Danqi Capsule (1 week), two week after taking Danqi Capsule (2 weeks).

Evaluation of an automated light transmission aggregometry.

Light transmission aggregometry (LTA) is the "gold standard" for platelet function assessment, but it is time-consuming and labor intensive. Recently, an automated platelet aggregation method has been developed on a routine coagulation analyzer (Sysmex CS-2100i). In this study, the performances of CS-2100i including repeatability, correlation with a reference aggregometer (Chrono-log Model 700), and the threshold limitation of platelet counts in platelet-rich plasma (PRP) were evaluated for clinical use.

Intestinal absorption characteristics of imperialine: in vitro and in situ assessments.

Aim: Imperialine is an effective compound in the traditional Chinese medicine chuanbeimu (Bulbus Fritillariae Cirrhosae) that has been used as antitussive/expectorant in a clinical setting. In this study we investigated the absorption characteristics of imperialine in intestinal segments based on an evaluation of its physicochemical properties.

Methods: Caco-2 cells were used to examine uptake and transport of imperialine in vitro, and a rat in situ intestinal perfusion model was used to characterize the absorption of imperialine.