Publications by authors named "Li-Qiang Zhi"
Article Synopsis
- Genome-wide association studies have linked certain non-coding SNPs at 2p14 to rheumatoid arthritis, but their functional roles weren't fully understood until now.
- This study identified three specific intronic SNPs that regulate the expression of the gene SPRED2, which plays a crucial role in controlling the harmful behavior of cells involved in RA.
- The interactions between SPRED2 and another protein, ACTR2, create a feedback loop that enhances protection against RA, suggesting SPRED2 as a potential target for more precise RA treatments.
Article Synopsis
- This study aims to explore how serum neutrophil extracellular traps (NETs) and soluble vascular cell adhesion molecule-1 (sVCAM-1) correlate with the occurrence of deep venous thromboembolism (DVT) after knee arthroplasty.
- Researchers analyzed data from 30 DVT patients and 60 non-DVT patients post-surgery to compare serum levels of NETs and sVCAM-1 at various intervals and identify potential influencing factors.
- Results indicated that the DVT group had higher levels of serum NETs and sVCAM-1 shortly after surgery, with certain factors like age and body mass index also linked to increased DVT risk; positive correlations between the two serum markers were
Article Synopsis
- The study aimed to evaluate the effects of sliding osteotomy for patients with severe knee osteoarthritis and varus knee deformities, particularly in achieving balance during total knee arthroplasty.
- A total of 22 patients (5 males and 17 females, average age 61.3 years) with complex femoral deformities underwent the procedure, with assessments indicating significant pre-operative malalignment and low functional scores.
- Post-operative results showed no complications; significant improvements were recorded in HKA angles and Knee Society Scores (KSS), demonstrating successful correction and enhanced knee function over an average follow-up period of 28.2 months.
Article Synopsis
- * This study performed "Target-Pathway" network analysis to identify new potential drug targets for OS, using various databases and scientific literature, with a focus on tankyrase 2 (TNKS2).
- * The findings indicate that TNKS2 could serve as an effective target for OS treatment, as in vitro tests showed that inhibiting TNKS2 leads to cell cycle arrest and increased cell death.
Article Synopsis
- Osteoarthritis (OA) is a degenerative joint disease where inflammation worsens cartilage breakdown, and Hydroxytyrosol (HT) has shown potential in managing inflammation.
- * The study explores how HT affects autophagy (a cellular cleanup process) and inflammation in chondrocytes, specifically focusing on the role of Sirtuin 6 (SIRT6) as a mediator.
- * Results indicated that HT reduces inflammatory cytokines and boosts SIRT6 expression, suggesting it combats inflammation in chondrocytes through SIRT6-regulated autophagy, making HT a potential target for treating inflammatory diseases.*
Article Synopsis
- * TRIM29 levels were found to be significantly higher in osteosarcoma tissues compared to normal bone, correlating with tumor size, recurrence, metastasis, and overall survival rates in patients.
- * The findings suggest that TRIM29 not only serves as a potential prognostic biomarker but also as a therapeutic target, as it promotes the invasive characteristics of osteosarcoma cells through mechanisms like epithelial-mesenchymal transition.
Despite the knowledge on many genetic variants present in osteosarcoma, the complexity of this disease precludes placing its biology into a simple conceptual framework. RECQL is a DNA helicase involved in DNA mismatch repair and has been reported to be associated with many human cancers. We aimed to investigate the association of RECQL genetic polymorphism with osteosarcoma in a Chinese population.
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