Publications by authors named "Li-Ping Tong"
Article Synopsis
- This study aimed to explore the relationship between tissue and plasma samples in detecting EGFR mutations in early-stage non-small cell lung cancer (NSCLC).
- Researchers analyzed tissue and plasma from 198 NSCLC patients, finding a low sensitivity of 17.2% for detecting EGFR mutations in plasma compared to tissue, which varied significantly based on disease stage and tumor differentiation.
- The findings suggest that plasma cfDNA could be a reliable biomarker for gene diagnostics, particularly in stage IIIA or poorly differentiated tumors, when tissue samples are not available, as it reflects mutation types that can represent various tumor areas.
Serum/plasma microRNAs as biomarkers for HBV-related hepatocellular carcinoma in China.
Biomed Res Int
November 2015
MicroRNAs (miRNAs) are a group of small RNAs with a fundamental role in the regulation of gene expression. These RNAs have been shown to participate in various cellular and physiological processes, including cellular development, apoptosis, proliferation, and differentiation. Aberrant expression of several miRNAs was found to be involved in a large variety of neoplasms, including hepatocellular carcinoma (HCC).
View Article and Find Full Text PDFBackground: The international nasopharynx cancer (NPC) burdens are masked due to the lack of integrated studies that examine epidemiological data based on up-to-date international disease databases such as the Cancer Information (CIN) databases provided by the International Agency for Research on Cancer (IARC).
Methods: By analyzing the most recently updated NPC epidemiological data available from IARC, we tried to retrieve the worldwide NPC burden and patterns from combined analysis with GLOBOCAN2008 and the Cancer Incidence in Five Continents (CI5) databases. We provide age-standardized rates (ASR) for NPC mortality in 20 highest cancer registries from GLOBOCAN2008 and the World Health Organization (WHO) mortality databases, respectively.
A series of cationic fluorine-containing amphiphilic graft copolymers P(HFMA-St-MOTAC)-g-PEG comprising poly(hexafluorobutyl methacrylate) (PHFMA) poly(methacryl oxyethyl trimethylammonium chloride) (PMOTAC) polystyrene (PSt) backbones and poly(ethylene glycol) (PEG) side chains are synthesized as a type of non-viral gene vector. The copolymers self-assemble into spherical micelles in the aqueous media and turbidity and cytotoxicity measurements show that those micelles have excellent dispersive stability and low cytotoxicity. The interactions between the copolymers and calf-thymus DNA are studied by fluorescence spectroscopy and viscosity.
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